Scintigraphic assessment of the in vivo dissolution rate of a sustained release tablet

Daly, Paul; Davis, S.S.; Frier, M; Hardy, John G.; Kennerley, JW; Wilson, Clive G.

doi:10.1016/0378-5173(82)90058-8

Cited by 41 publications

(2 citation statements)

References 15 publications

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“…Very early, attempts to characterize tablet movement were done, using Xrays (9,10) or the so-called Jo-Jo technique (the tablet is attached with a band, swallowed, and withdrawn from the stomach to measure in vivo disintegration) (11). The radioelemetry method employs a pH-sensitive radiotransmitting reusable capsule whose signal is used to determine the position of the capsule in the abdomen (12).…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions

2015

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Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions

2015

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“…This can now be done non-invasively with minimal irradiation using radioisotope techniques. 16 17 Under the gamma camera an isotopically labelled tablet can readily be identified and its disintegration assessed from the fall in counts (corrected for radioactive decay) in a region of interest drawn around the tablet image. Disintegration assessed in this way correlates well with appearance of drug in the plasma18 and the method looks promising.…”

Section: Gastric Dispersionmentioning

confidence: 99%

Where do all the tablets go in 1986?

Spiller¹

1986

Gut

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Gastrointestinal Behavior of Orally Administered Radiolabeled Erythromycin Pellets in Man as Determined by Gamma Scintigraphy

Digenis

Sandefer

Parr

et al. 1990

The Journal of Clinical Pharma

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The behavior of single 250-mg doses of a multiparticulate form of erythromycin base (ERYC(R)), each including five pellets radiolabeled with neutron-activated samarium-153, was observed by gamma scintigraphy in seven male subjects under fasting and nonfasting conditions. The residence time and locus of radiolabeled pellets within regions of the gastrointestinal tract were determined and were correlated with plasma concentrations of erythromycin at coincident time points. Administration of food 30 minutes postdosing reduced fasting plasma erythromycin Cmax and area under the plasma erythromycin versus time curve (AUC) values by 43% and 54%, respectively. Mean peak plasma concentration of erythromycin (Cmax) in the fasting state was 1.64 micrograms/mL versus 0.94 micrograms/mL in the nonfasting state. Total oral bioavailability, as determined by mean AUC (0-infinity) of the plasma erythromycin concentration versus time curve, was 7.6 hr/micrograms/mL in the fasted state, versus 3.5 hr/micrograms/mL in the nonfasting state. Mean time to peak plasma erythromycin concentration (tmax) in the fasting state was 3.3 hours, versus 2.3 hours in the nonfasting state. Plasma concentrations of erythromycin in both fasting and nonfasting states were within acceptable therapeutic ranges. Evidence provided by this study: 1) indicates that pellet erosion and absorption of active erythromycin base begins when the enteric-coated pellets reach the highly vascular mucosa of the jejunum and proximal ileum, and is essentially completed within the ileum, with a significant portion absorbed in the medial-to-distal ileum; 2) confirms that acceptable therapeutic plasma levels of erythromycin are attained in nonfasting subjects (Cmax = 0.94 microgram/mL) and that superior plasma erythromycin concentrations (Cmax = 1.64 micrograms/mL) are achieved by administration of the dose on an empty stomach 1 to 2 hours before or after meals; 3) corroborates other comparative studies reporting greater fasting bioavailability with this multiparticulate dosage form of erythromycin base than with reference single tablet or particle-in-tablet formulations; and 4) indicates that neutron activation of stable isotopes incorporated as a normal excipient in industrially-produced formulations provides an effective means for in vivo evaluation of dosage forms through gamma scintigraphy.

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Scintigraphic assessment of the in vivo dissolution rate of a sustained release tablet

Cited by 41 publications

References 15 publications

Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions

Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions

Where do all the tablets go in 1986?

Gastrointestinal Behavior of Orally Administered Radiolabeled Erythromycin Pellets in Man as Determined by Gamma Scintigraphy

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