“…In the current scenario we must pay attention to the management of ischemic brain damage with relevant research findings ( O’Rourke, 2004 ). Among the phytoactives, Gallic acid (GA), 3,4,5-trihydroxybenzoic acid, was more focussed by researchers, with its unique and potential constituents present in various parts of plants and different fruits like grapes ( Cedó et al, 2014 , Scoccia et al, 2016 , Yang et al, 2020 ), gallnuts ( Liu et al, 2019 , Wang and Li, 2017 ), pomegranates ( Singh et al, 2014 , Zhang et al, 2018 ), and tea leaves ( Jiang et al, 2019 ). To be specific, GA and derivatives are used as flavouring agents and preservatives in food industry ( Alfei et al, 2019 , Fereidoonfar et al, 2019 ) also it has many pharmaceutical applications as antioxidants ( Phonsatta et al, 2017 , Wang et al, 2019 ), antimicrobial ( Wang et al, 2019 ) ( Rosman et al, 2018 ), anticancer ( T. Zhang et al, 2019 ), anti-inflammatory, gastroprotective ( Pandurangan et al, 2015 ), cardioprotective ( El-Hussainy et al, 2016 ), neuroprotective ( Maya et al, 2018b ), in addition to the usage in prevention of metabolic diseases ( Bak et al, 2013 , Huang et al, 2016 ).…”