A new cerebral ischemic injury model in rats, preventive effect of gallic acid and in silico approaches

Kumar, P. Praveen; Madhuri, D.; Reddy, L.S.S. Varaprasad; Reddy, Y. Dastagiri; Somasekhar, Gopalam; Sirisha, N; Nagaraju, K.; Shouib, M.S.; Rizwaan, A.S.

doi:10.1016/j.sjbs.2021.05.044

Cited by 6 publications

(4 citation statements)

References 72 publications

(71 reference statements)

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“…The histopathology results supported and confirmed these aforementioned results as the liver tissues of GA and Met groups displayed histology scores normalization, nearly-looking hepatic and brain architecture, in harmony with earlier studies [ 42 , 53 ]. Also, recent studies showed fewer necrotic cells and normal-looking neurons and glial cells after treatment with GA or Met, in agreement with our results [ 54 , 55 ].…”

Section: Discussionsupporting

confidence: 93%

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Mohamed

Hafez

2023

BMC Complement Med Ther

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Background Hepatic encephalopathy (HE) is a consequence of chronic or acute liver diseases. This study evaluates the combined effect of gallic acid (GA), and metformin (Met) on the liver and brain damage associated with HE. Methods Acute HE was induced by a single dose of thioacetamide (TAA) (300 mg/kg) as an I.P. injection. Treated groups received GA group (100 mg/kg/day, p.o), Met (200 mg/kg/day, p.o), or their combination for 25 consecutive days before TAA injection. Results The administration of TAA induced various biochemical and histopathological alterations. In contrast, treatment with GA either alone or combined with Met resulted in improved liver functions by the significant reduction in serum ALT, AST, and ALP activities, and ammonia levels. Inflammatory mediators; TNF-α, IL-6, and NFkβ levels were decreased by these treatments as well as apoptotic cascade via down-regulation of FAS and caspase-3 (CASP-3) expression in hepatic tissues. Furthermore, GA and Met either alone or combined protected the liver and brain tissues from damage by increased glutathione concentration while decreasing malondialdehyde. In addition, it was accompanied by the improvement of the brain neurotransmitter profile via the restoration of norepinephrine, dopamine, and serotonin levels. Based on our data, this is the first study to report a novel combined hepatoprotective and cognitive enhancing effect of GA and Met against TAA-induced acute liver and brain injury. Conclusion GA and Met combination resulted in a prominent improvement in HE complications, relative to monotherapy. Both agents potentiated the antioxidant, anti-inflammatory, and anti-apoptotic effects of each other.

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Section: Discussionsupporting

confidence: 93%

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Mohamed

Hafez

2023

BMC Complement Med Ther

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“…It is important to highlight that GA, one of the most important hydroxybenzoic acids and widely distributed in plants, has shown several biological activities in many diseases, including cardiovascular diseases, cancer, neurodegenerative disorders, and aging [ 44 , 45 ]. In fact, previous studies have revealed that GA exerts a protective role against kidney damage [ 46 ] and cerebral ischemic injury [ 47 ] due to its strong binding affinity on targeted noxious compounds which has been attributed to its antioxidant and anti-inflammatory activities [ 48 ].…”

Section: Resultsmentioning

confidence: 99%

High-Intensity Ultrasound Processing Enhances the Bioactive Compounds, Antioxidant Capacity and Microbiological Quality of Melon (Cucumis melo) Juice

Rodríguez-Rico

Sáenz-Esqueda

Meza-Velázquez

et al. 2022

Foods

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The bioactive compounds, antioxidant capacity and microbiological quality of melon juice processed by high-intensity ultrasound (HIUS) were studied. Melon juice was processed at two ultrasound intensities (27 and 52 W/cm2) for two different processing times (10 and 30 min) using two duty cycles (30 and 75%). Unprocessed juice was taken as a control. Total carotenoids and total phenolic compounds (TPC) were the bioactive compounds analyzed while the antioxidant capacity was determined by DPPH, ABTS and FRAP assays. The microbiological quality was tested by counting the aerobic and coliforms count as well as molds and yeasts. Total carotenoids increased by up to 42% while TPC decreased by 33% as a consequence of HIUS processing regarding control juice (carotenoids: 23 μg/g, TPC: 1.1 mg GAE/g), gallic acid and syringic acid being the only phenolic compounds identified. The antioxidant capacity of melon juice was enhanced by HIUS, achieving values of 45% and 20% of DPPH and ABTS inhibition, respectively, while >120 mg TE/100 g was determined by FRAP assay. Further, the microbial load of melon juice was significantly reduced by HIUS processing, coliforms and molds being the most sensitive. Thus, the HIUS could be an excellent alternative supportive the deep-processing of melon products.

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“…GA can ameliorate left ventricular dysfunction and hypertrophy, which are associated with diabetes, and reduce the ischemia–reperfusion-induced myocardial infarction area 15 , 16 . It can also mitigate oxidative stress injury caused by renal ischemia-reperfusion 17 , elevate antioxidant levels in brain tissue and reduce cerebral infarction attributed to cerebral IRI 18 . After pretreating patients with cyclophosphamide, GA can diminish inflammatory and oxidative stress injury to the kidneys in IRI induced by cyclophosphamide 19 .…”

Section: Introductionmentioning

confidence: 99%

Gallic acid pretreatment mitigates parathyroid ischemia–reperfusion injury through signaling pathway modulation

Liu,

Liang,

Hong

et al. 2024

Sci Rep

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Thyroid surgery often results in ischemia–reperfusion injury (IRI) to the parathyroid glands, yet the mechanisms underlying this and how to ameliorate IRI remain incompletely explored. Our study identifies a polyphenolic herbal extract—gallic acid (GA)—with antioxidative properties against IRI. Through flow cytometry and CCK8 assays, we investigate the protective effects of GA pretreatment on a parathyroid IRI model and decode its potential mechanisms via RNA-seq and bioinformatics analysis. Results reveal increased apoptosis, pronounced G1 phase arrest, and significantly reduced cell proliferation in the hypoxia/reoxygenation group compared to the hypoxia group, which GA pretreatment mitigates. RNA-seq and bioinformatics analysis indicate GA’s modulation of various signaling pathways, including IL-17, AMPK, MAPK, transient receptor potential channels, cAMP, and Rap1. In summary, GA pretreatment demonstrates potential in protecting parathyroid cells from IRI by influencing various genes and signaling pathways. These findings offer a promising therapeutic strategy for hypoparathyroidism treatment.

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A new cerebral ischemic injury model in rats, preventive effect of gallic acid and in silico approaches

Abstract: Graphical abstract

Cited by 6 publications

References 72 publications

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

Gallic acid and metformin co-administration reduce oxidative stress, apoptosis and inflammation via Fas/caspase-3 and NF-κB signaling pathways in thioacetamide-induced acute hepatic encephalopathy in rats

High-Intensity Ultrasound Processing Enhances the Bioactive Compounds, Antioxidant Capacity and Microbiological Quality of Melon (Cucumis melo) Juice

Gallic acid pretreatment mitigates parathyroid ischemia–reperfusion injury through signaling pathway modulation

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