Suspected Pulmonary Embolism after Oxygen-Ozone Therapy for Low Back Pain

Chirchiglia, Domenico; Caldarola, Pasquale; Stroscio, Carmelino Angelo; Volpentesta, Giorgio; Lavano, Angelo

doi:10.1055/s-0039-1685197

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Only very few serious complications have been described so far, e.g., a suspected pulmonary embolism after ozone therapy for low back pain. [ 13 ] Here, the authors believe that a venous vessel was accidentally punctured during intradiscal injection which created emboli, leading to the occurrence of massive pulmonary embolism. Three other cases of gas emboli/stroke have been reported in the literature that are all associated with (intradiscal) ozone injections: a patient with chronic neck pain treated with paravertebral ozone injection, leading to multifocal stroke,[ 14 ] a case of vertebrobasilar stroke[ 15 ] and finally a case of paradoxical embolism resulting in anterior spinal cord syndrome and consecutive acute myocardial infarction following intradiscal injection of ozone.…”

Section: R Esultsmentioning

confidence: 99%

The role of ozone therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19): a review

Harapan

Harapan²

2023

Med Gas Res

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Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has rapidly swept across the world. As new knowledge regarding treatment options for COVID-19 has emerged, the use of ozone therapy in the context of SARS-CoV-2 infection as an integrative therapeutic option supplementary to standard treatment regimen has been assessed in the present literature. We reviewed, critically analyzed, and summarized all present published literature on ozone therapy in association with COVID-19 via the PubMed database. Various reports and studies on the use of ozone (major autohemotherapy, rectal ozone insufflation, ozone inhalation) in patients affected by COVID-19 indicate that ozone therapy may reduce morbidity and accelerate recovery, while exhibiting a high safety profile with no relevant adverse effects. Current literature suggests that integrating ozone therapy into the existing standard of care and best available therapy for the treatment of COVID-19 patients offers major advantages in terms of superior clinical outcome parameters and amelioration of laboratory results. Further prospective studies are warranted to guide the next steps in the clinical application of ozone therapy and examine its impact on the course of COVID-19.

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Section: R Esultsmentioning

confidence: 99%

The role of ozone therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19): a review

Harapan

Harapan²

2023

Med Gas Res

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“…16 In general, it is a very safe therapy when administered correctly, with the recommended dose. Complications like air embolism have been described 17 but are caused by incorrect administration practices and by using non-certified equipment.…”

Section: Introductionmentioning

confidence: 99%

Ozone therapy for patients with COVID-19 pneumonia: a Quasi-Randomized Controlled Trial

Hernández¹,

Viñals²,

Pablos³

et al. 2020

Preprint

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Importance Aside from supportive management, there remains no specific treatment for Coronavirus Disease 2019 (COVID-19). Objective: Determine whether ozonated autohemotherapy is associated with a shorter time to clinical improvement in patients with severe COVID-19 pneumonia. Design: Single-center proof-of-concept prospective cohort study. Setting: Internal Medicine ward at Policlinica Ibiza Hospital, Spain. Participants: Eighteen consecutive patients with laboratory confirmed COVID-19 infection and severe pneumonia who were admitted to hospital between 20th March and 19th April 2020. Exposures: Patients in the ozonated autohemotherapy arm received hemotherapy twice daily starting on the day of admission for a median of 4 days. Each treatment involved administration of 200 mL autologous whole blood enriched with 200 mL of oxygen-ozone mixture with a 40 μg/mL ozone concentration. Patients in the control arm received supportive care. Assignment to hemotherapy versus usual care was determined based on the admitting physician on the day of admission, with only one of the three possible physicians prescribing ozonated autohemotherapy Main Outcomes: The primary outcome was time from hospital admission to clinical improvement, which was defined as either hospital discharge or a two-point improvement in clinical status measured on a six-point ordinal scale. Secondary outcomes were clinical improvement measured on the 7th, 14th and 28th day after admission, as well as time to a 2-fold reduction in concentrations of C-protein reactive, ferritin, D-dimer and lactate dehydrogenase. Results: The mean age of the cohort was 68 y and 72% (n=13) were male. Nine patients (50%) received ozonated autohemotherapy beginning on the day of admission. In unadjusted comparisons, ozonated autohemotherapy was associated with significantly shorter time to clinical improvement (median [IQR]), 7 days [6-10] vs 28 days [8-31], p=0.04) and significantly higher proportion of patients achieving 14-day clinical improvement (88.8% vs 33.3%, p=0.01). In risk-adjusted analyses, ozonated autohemotherapy was associated with a shorter mean time to clinical improvement (-11.3 days, p=0.04, 95% CI -22.25 to -0.42). Conclusions and Relevance: Ozonated autohemotherapy was associated with a significantly shorter time to clinical improvement in this prospective cohort study. Given the small sample size and single-center study design, these observations require evaluation in larger randomized controlled trials.

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Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study

Hernández

Viñals

Pablos

et al. 2021

International Immunopharmacology

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Suspected Pulmonary Embolism after Oxygen-Ozone Therapy for Low Back Pain

Cited by 4 publications

References 10 publications

The role of ozone therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19): a review

The role of ozone therapy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19): a review

Ozone therapy for patients with COVID-19 pneumonia: a Quasi-Randomized Controlled Trial

Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study

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