Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study

Hernández, A.; Viñals, Montserrat; Pablos, Asunción; Vilas, Francisco; Papadakos, Peter J.; Wijeysundera, Duminda N.; Bergese, Sergio D.; Vives, Marc

doi:10.1016/j.intimp.2020.107261

Cited by 35 publications

(86 citation statements)

References 43 publications

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“…In our study, mortality rate in Ozone-group was 8.3% whereas in Standard-of-care group was 16.6%. Hernandez et al have reported a mortality rate of 11% for ozone-group, and 22% for Standard-of-care Group, a rate very similar to ours 24 . Tascini et al have stated that poor clinical outcome was inferior in Ozone (7%) that in Standard-of-care (17%), and the mortality rate was 0% in Ozone-Group and 7% in the Standard-of-care Group 22 .…”

Section: Discussionsupporting

confidence: 89%

“…In Schwartz' study (Ozonized saline solution in before-and-after design), patients were 55 years and 0.84 comorbidities 23 . In Hernández' study (Ozone autohemotherapy in prospective case-control study) Ozone-Group was 64 years and 0.77 comorbidities, while Control-Group was 71 years and 1.2 comorbidities 24 . In the previous studies referenced, there is a clear association between age and number of comorbidities.…”

Section: Discussionmentioning

confidence: 95%

“…It is expected that older patients show worst clinical outcomes, but Ozone was effective even in older COVID-19 patients 11 . As far as we know, our study has treated the oldest patients, if compared with other ozone studies [21][22][23][24] . 21 .…”

Section: Discussionmentioning

confidence: 98%

“…Unfortunately, no speci c drug or drug regimen has been approved for COVID-19. In the pathogenesis of COVID-19, two clinical presentations are the most observed The number of sessions in autohemotherapy varied from 3 to 7 sessions 5,21,22,24 , in ozonized saline solution was 10 sessions 23 and in Rectal Ozone the sessions were 7.8 on average.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, by the10 th day of treatment, Fibrinogen and LDH were on normal ranges in all COVID-19 patients 23 . Hernandez et al have stated that Ozone autohemotherapy decreased in ammatory biomarkers (Ferritin, LDH, D-Dimer and CRP) signi cantly at 7 days after treatment started 24 . Although Franzini's, Tascini's and Hernandez' Studies used Ozone autohemotherapy and Schwartz' study used Ozonized saline solution, their results were similar to our approach (rectal Ozone insu ation); that is, Ozone in its different administration techniques, was capable of decreasing such biomarkers of in ammation.…”

Section: Discussionmentioning

confidence: 99%

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Compassionate use of rectal Ozone (O3) in severe COVID-19 pneumonia: a case-control study.

Fernández-Cuadros

Albaladejo-Florín

Álava-Rabasa

et al. 2021

Preprint

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Objectives: To evaluate effect of rectal Ozone in severe COVID-19 pneumonia and to compare to Standard-of-care (SOC). Material and Methods: In a case-control study, 14 patients with severe bilateral COVID-19 pneumonia (positive RT-PCR), treated with SOC and rectal Ozone, were evaluated before-and-after treatment and compared with SOC (14 patients) in a 10 day follow-up period. Ozone-protocol consisted of 8 sessions (1 session/day) of intra-rectal Ozone, (150mL volume, 35mg/ml concentration [5.25mg total dose]). The SOC-protocol included O 2- supply, antivirals (Remdesivir), corticosteroids (Dexamethasone/Metilprednisolone), monoclonal antibodies (Anakinra/Tocilizumab), antibiotics (Azytromicine), anticoagulants (Enoxaparine) and hyperimmune serum (if necessary). Primary outcome variables: a) clinical (O 2- saturation and O 2- supply); b) biochemical (Lymphocyte count, Fibrinogen, D-Dimer, Urea, Ferritin, LDH, IL-6 and CRP); c) radiological Taylor Scale. Secondary outcome variables: a) hospitalization length-of-stay, b) mortality-rate. Results: At baseline, Ozone/SOC-groups were not different on age, comorbidities, O 2 -saturation and O 2 -supply. Patients in Ozone-Group improved O 2- saturation and decrease O 2- supply. SOC maintained O 2- saturation and required more O 2- supply. Lymphocyte-count improved only in Ozone-group and with statistical difference (p<0.05). Biomarkers of inflammation (Fibrinogen, D-Dimer, Urea, LDH, CRP and IL-6) decreased in both groups, but only significantly in favor of Ozone-group (p<0.05). Ferritin showed a significant decrease in the Ozone-group but an increase on the SOC-Group. Radiological pneumonitis decreased on both groups but the decrease was only significant in the Ozone-Group (p<0.0001). Mortality and length-of-stay, although not significant, were inferior in Ozone-Group. Conclusion: Compassionate use of Rectal Ozone improved O 2 -saturation, reduced O 2 -supply, decreased inflammation biomarkers and improved Taylor’s radiological scale significantly when compared to SOC-Group. Mortality and length-of-stay was inferior in the Ozone-group, but this difference was not significant.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Compassionate use of rectal Ozone (O3) in severe COVID-19 pneumonia: a case-control study.

Fernández-Cuadros

Albaladejo-Florín

Álava-Rabasa

et al. 2021

Preprint

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Science's Response to CoVID‐19

Long

Aye

2021

ChemMedChem

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CoVID‐19 is a multi‐symptomatic disease which has made a global impact due to its ability to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop vaccines, which we do not discuss herein, the response of scientists and clinicians to this complex problem has reflected the need to detect CoVID‐19 rapidly, to diagnose patients likely to show adverse symptoms, and to treat severe and critical CoVID‐19. Here we aim to encapsulate these varied and sometimes conflicting approaches and the resulting data in terms of chemistry and biology. In the process we highlight emerging concepts, and potential future applications that may arise out of this immense effort.

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Ozontherapie bei Covid-19-Erkrankung

Thiele

2024

Prävention Und Therapie Viraler Epidemien

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Ozone therapy for patients with COVID-19 pneumonia: Preliminary report of a prospective case-control study

Cited by 35 publications

References 43 publications

Compassionate use of rectal Ozone (O3) in severe COVID-19 pneumonia: a case-control study.

Compassionate use of rectal Ozone (O3) in severe COVID-19 pneumonia: a case-control study.

Science's Response to CoVID‐19

Ozontherapie bei Covid-19-Erkrankung

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