Abstract:Importance Aside from supportive management, there remains no specific treatment for Coronavirus Disease 2019 (COVID-19).
Objective: Determine whether ozonated autohemotherapy is associated with a shorter time to clinical improvement in patients with severe COVID-19 pneumonia.
Design: Single-center proof-of-concept prospective cohort study.
Setting: Internal Medicine ward at Policlinica Ibiza Hospital, Spain.
Participants: Eighteen consecutive patients with laboratory confirmed COVID-19 infection and severe… Show more
“…Ozone has virtually no side effects and does not induce microbial resistance patterns like pharmacologic therapies [267]. Numerous studies affirm ozone's efficacy and safety in Covid-19 disease [267][268][269][270][271][272][273][274][275][276][277][278][279][280][281]. Thorp et al describe mechanisms by which ozone therapy affects Covid-19 outcomes: increased antioxidant production, induction of Nrf2-and HO-1-mediated nuclear mechanisms, down-regulation of pro-inflammatory immune pathways, direct toxic viral effects, inhibition of viral replication and increased blood and tissue oxygenation [279].…”
Section: The Case For Ozonementioning
confidence: 99%
“…Ozone therapy reduced viral titers and improved clinical symptoms in Covid-19-infected ICU patients [280]. Other studies found that ozone shortened time-lines for clinical improvement [281]. Since ozone confers protection against organ-injury in ischemia-reperfusion injury it only stands to reason that it should prevent or mitigate multi-system organ failure associated with advanced Covid-19 infection if administered in a time-sensitive manner.…”
It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science.
“…Ozone has virtually no side effects and does not induce microbial resistance patterns like pharmacologic therapies [267]. Numerous studies affirm ozone's efficacy and safety in Covid-19 disease [267][268][269][270][271][272][273][274][275][276][277][278][279][280][281]. Thorp et al describe mechanisms by which ozone therapy affects Covid-19 outcomes: increased antioxidant production, induction of Nrf2-and HO-1-mediated nuclear mechanisms, down-regulation of pro-inflammatory immune pathways, direct toxic viral effects, inhibition of viral replication and increased blood and tissue oxygenation [279].…”
Section: The Case For Ozonementioning
confidence: 99%
“…Ozone therapy reduced viral titers and improved clinical symptoms in Covid-19-infected ICU patients [280]. Other studies found that ozone shortened time-lines for clinical improvement [281]. Since ozone confers protection against organ-injury in ischemia-reperfusion injury it only stands to reason that it should prevent or mitigate multi-system organ failure associated with advanced Covid-19 infection if administered in a time-sensitive manner.…”
It is said that no discovery is complete until its implications have been fully realized. The identification of a previously unrecognized phenomenon says little of its potential effects. What appears as a stroke of good luck can culminate in disaster; misfortune may harbor unimagined potential. Discovery is a double-edged sword that manifests only over time. Nowhere is this aphorism more applicable than in contemporary medical science.
“…Oxygen/ozone therapy (another treatment known to promote antioxidant response) has also been proposed to help protect against ischemia‐reperfusion injury and other pathological manifestations of severe CoVID‐19 [302] . Some reports on small cohorts of patients have reported numerical, but not statistically‐significant effects of ozone on CoVID‐19; [302] others, with similarly small numbers of people have reported positive effects [303] …”
CoVID‐19 is a multi‐symptomatic disease which has made a global impact due to its ability to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop vaccines, which we do not discuss herein, the response of scientists and clinicians to this complex problem has reflected the need to detect CoVID‐19 rapidly, to diagnose patients likely to show adverse symptoms, and to treat severe and critical CoVID‐19. Here we aim to encapsulate these varied and sometimes conflicting approaches and the resulting data in terms of chemistry and biology. In the process we highlight emerging concepts, and potential future applications that may arise out of this immense effort.
“…301 Some reports on small cohorts of patients have reported numerical, but not statistically-significant effects of ozone on CoVID-19; 301 others, with similarly small numbers of people have reported positive effects. 302 A recent study showed numerous pathways rewired upon CoVID-19 infection, including processing mRNA and several metabolic elements, including nucleic acid metabolism pathways. Inhibition of proteins identified in such pathways (albeit often by compounds not in clinical use) appeared to inhibit viral proliferation, although the effects on host cells were not thoroughly investigated.…”
Section: Targeting Infection and Harnessing Fortuitous Antiviral Effementioning
CoVID-19 is a multi-symptomatic disease which has made a global impact due to its ability to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop vaccines, which we will not discuss, the response of scientists and clinicians to this complex problem has reflected the need to detect CoVID-19 rapidly, to diagnose patients likely to show adverse symptoms, and to treat severe and critical CoVID-19. Here we aim to encapsulate these varied and sometimes conflicting approaches and the resulting data in terms of chemistry and biology. In the process we highlight emerging concepts, and potential future applications that may arise out of this immense effort.
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