Susceptibility of the Y58 rodent-adapted strain of Trypanosoma vivax to two trypanocides in sheep

Arowolo, R. O. A.; Bo, Ikede

doi:10.1136/vr.106.3.59

Cited by 3 publications

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“…Several early studies were conducted in more affordable mouse or rat experimental models of infection in attempts to throw light on trypanotolerance, antigenic variation, the pathogenesis of intravascular coagulation, and T. vivax immunobiology and dynamics [7], [11], [19], [22], [23], [24], [25]. However, these studies used a variety of more or less virulent isolates from cattle, goats, sheep, horses and donkeys to explore the ability of T. vivax stocks to infect several intact or immunosuppressed mouse strains.…”

Section: Introductionmentioning

confidence: 99%

Trypanosoma vivax Infections: Pushing Ahead with Mouse Models for the Study of Nagana. I. Parasitological, Hematological and Pathological Parameters

et al. 2010

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African trypanosomiasis is a severe parasitic disease that affects both humans and livestock. Several different species may cause animal trypanosomosis and although Trypanosoma vivax (sub-genus Duttonella) is currently responsible for the vast majority of debilitating cases causing great economic hardship in West Africa and South America, little is known about its biology and interaction with its hosts. Relatively speaking, T. vivax has been more than neglected despite an urgent need to develop efficient control strategies. Some pioneering rodent models were developed to circumvent the difficulties of working with livestock, but disappointedly were for the most part discontinued decades ago. To gain more insight into the biology of T. vivax, its interactions with the host and consequently its pathogenesis, we have developed a number of reproducible murine models using a parasite isolate that is infectious for rodents. Firstly, we analyzed the parasitical characteristics of the infection using inbred and outbred mouse strains to compare the impact of host genetic background on the infection and on survival rates. Hematological studies showed that the infection gave rise to severe anemia, and histopathological investigations in various organs showed multifocal inflammatory infiltrates associated with extramedullary hematopoiesis in the liver, and cerebral edema. The models developed are consistent with field observations and pave the way for subsequent in-depth studies into the pathogenesis of T. vivax - trypanosomosis.

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