Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris

Marcinkiewicz, Janusz; Biedroń, Rafał; Białecka, Anna; Kasprowicz, A; Mak, Monika; Targosz, Marta

doi:10.1007/s00005-006-0007-1

Cited by 27 publications

(33 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taurolidine, a derivative of free amino acid taurine, has a signifi cant effect on supragingival plaque biofi lm, although not as pronounced as that of CHX (Arweiler et al 2012 ). These data clearly support our idea to examine anti-plaque properties of taurine haloamines, taurine chloramine (TauCl) and taurine bromamine (TauBr), the agents with known antimicrobial properties against various pathogens (Mainnemare et al 2004 ;Marcinkiewicz et al 2006Marcinkiewicz et al , 2013aPasich et al 2013a ). Moreover, clinical studies have shown that both haloamines are effective in the local treatment of skin and mucous infections, including biofi lm-related infections (Coraça-Huber et al 2014 ;Marcinkiewicz et al 2008Marcinkiewicz et al , 2013bNagl et al 2000 ).…”

Section: Introductionsupporting

confidence: 69%

See 1 more Smart Citation

Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm

Pasich

Walczewska

Białecka³

et al. 2015

Taurine 9

Self Cite

View full text Add to dashboard Cite

Section: Introductionsupporting

confidence: 69%

“…Moreover, our study shows that TauBr may be used alternatively or in combination with CHX in killing of oral biofi lm pathogens, due to its strong antibacterial and anti-infl ammatory properties reported in a number of previous papers (Marcinkiewicz et al 2005(Marcinkiewicz et al , 2006Walczewska et al 2013 ).…”

Section: Discussionmentioning

confidence: 82%

Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm

Pasich

Walczewska

Białecka³

et al. 2015

Taurine 9

Self Cite

View full text Add to dashboard Cite

“…It might be due to its unique size, which facilitates its permeation into the cell easily and hence causes cell damage. From a clinical point of view, it is very interesting to note that the susceptibility of P. acnes ( Figure 5) appeared to be significantly higher than that of S. epidermidis ( Figure 6) (37). Both species belong to the bacterial flora of the skin, but only P. acnes is reflected to be chief the pathogenetic agent of the chronic skin inflammation in acne vulgaris (38)(39)(40).…”

Section: Resultsmentioning

confidence: 96%

Green synthesis of silver nanoparticles by seed of Phoenix sylvestris L. and their role in the management of cosmetics embarrassment

Qidwai

Kumar

Dikshit

2018

Green Chemistry Letters and Reviews

View full text Add to dashboard Cite

Recently, green synthesis of silver nanoparticles has attracted much curiosity in the field of life science research. In the present study, we have reported a green method for synthesis of silver nanoparticles (AgNPs) using aqueous seed extract of Phoenix sylvestris L. The green synthesized nanoparticles were characterized by aids of dynamic light scattering, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and Fourier transform-infrared.Further, the study demonstrate the comparative phytochemical analysis as well as antioxidant and antibacterial activity of the extract and Phoenix sylvestris seed generated nanoparticles against acne-causing pathogens, that is, by using a DPPH-scavenging assay and broth microdilution method as well as Kirby-Bauer Disk diffusion method (recommended by CLSI), respectively. Moreover, a concentration-dependent time-kill kinetic studies were also carried out to determine their antimicrobial activity. The seed extract was found a better antioxidant and AgNPs exhibited highly biocidal agent against both the test pathogens, when compared to aqueous extracts. The results obtained indicate that seed extract of P. sylvestris is suitable for synthesizing stable silver nanoparticles, which act as excellent antimicrobial agents with promising treatments for cosmetics embarrassment. ARTICLE HISTORY

show abstract

“…In contrast, TauBr has attracted little attention because the extracellular concentration of bromide is at least 1,000-fold lower than that of chloride [2]. However, brominating intermediates such as HOBr and TauBr are potent antimicrobial agents in vitro [7,8]. …”

Section: Introductionmentioning

confidence: 99%

“…To determine the function of TauBr, taurine mono-bromamine has been synthesized in vitro and used in a variety of experimental systems [8,10]. In our studies we have used the following protocol for synthesis and detection of TauBr in vitro .…”

Section: Introductionmentioning

confidence: 99%

Taurine bromamine (TauBr) - its role in immunity and new perspectives for clinical use

Marcinkiewicz

2010

J Biomed Sci

Self Cite

View full text Add to dashboard Cite

This review is an attempt to summarize our knowledge about taurine bromamine (TauBr) properties, its role in innate immunity and its therapeutic potential.TauBr and taurine chloramine (TauCl) are major haloamines generated by eosinophils and neutrophils at a site of inflammation. Both haloamines share anti-inflammatory and anti-oxidant properties. TauBr, similarly to TauCl, decreases the production of proinflammatory mediators. Their anti-inflammatory and anti-oxidant activities are enhanced by their ability to induce the expression of heme oxygenase-1 (HO-1). TauCl is more stable than TauBr. On the other hand, only TauBr was found to be highly membrane-permeable showing stronger microbicidal activity than TauCl.In the light of the anti-inflammatory and antimicrobial properties of TauBr we discuss its therapeutic potential in local treatment of inflammation, especially acne vulgaris, the most common inflammatory skin disorder. TauBr, at non-cytotoxic concentrations, is able to kill Propionibacterium acnes, the skin bacteria involved in pathogenesis of acne vulgaris.As topical antibiotics used in the therapy of acne are associated with the emergence of resistant bacteria, topical TauBr seems to be a good candidate for an alternative therapy.Recently, in a double blind trial, the efficacy of TauBr was compared with the efficacy of clindamycin, one of the most common topical antibiotics used in acne therapy. Comparable reduction of acne lesions was observed in the TauBr and clindamycin groups of patients with mild and moderate inflammatory facial acne vulgaris. We conclude that this pilot study supports our concept that TauBr can be used as a topical agent in the treatment of acne vulgaris, especially in patients who have already developed antibiotic resistance. Further studies are necessary to substantiate the more extended use of TauBr as an anti-inflammatory and anti-oxidant agent in human medicine.

show abstract

Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris

Abstract: Since PA is considered to be an etiological agent in acne and ROS are closely correlated with the pathogenesis of inflammatory skin diseases, the reported data suggest that TauBr may be a good candidate for the topical therapy for acne vulgaris.

Cited by 27 publications

References 33 publications

Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm

Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm

Green synthesis of silver nanoparticles by seed of Phoenix sylvestris L. and their role in the management of cosmetics embarrassment

Taurine bromamine (TauBr) - its role in immunity and new perspectives for clinical use

Contact Info

Product

Resources

About