Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm

Pasich, Ewa; Walczewska, Maria; Białecka, Anna; Peruń, Angelika; Kasprowicz, A; Marcinkiewicz, Janusz

doi:10.1007/978-3-319-15126-7_12

Cited by 4 publications

(2 citation statements)

References 33 publications

(38 reference statements)

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“…Similarly, it has been proved that TauBr seems to be the most suitable topical agent for the treatment of biofilm-associated infections such as chronic sinusitis, otitis media, acne vulgaris, and periodontal diseases (4). The therapeutic efficacy of TauBr has especially been observed in the treatment of biofilm-associated infections (278). In another study, forty patients with mild to moderate inflammatory facial acne vulgaris were randomly enrolled and received either TauBr (3.5 mM) or classical antibiotic option (clindamycin-1%) for 6 weeks, twice a day.…”

Section: Therapeutic Perspectives and Clinical Studiesmentioning

confidence: 99%

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Baliou

Kyriakopoulos²,

Spandidos

et al. 2020

Int J Oncol

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For one century, taurine is considered as an end product of sulfur metabolism. In this review, we discuss the beneficial effect of taurine, its haloamines and taurine upregulated gene 1 (TUG1) long non-coding RNA (lncRNA) in both cancer and inflammation. We outline how taurine or its haloamines (N-Bromotaurine or N-Chlorotaurine) can induce robust and efficient responses against inflammatory diseases, providing insight into their molecular mechanisms. We also provide information about the use of taurine as a therapeutic approach to cancer. Taurine can be combined with other chemotherapeutic drugs, not only mediating durable responses in various malignancies, but also circumventing the limitations met from chemotherapeutic drugs, thus improving the therapeutic outcome. Interestingly, the lncRNA TUG1 is regarded as a promising therapeutic approach, which can overcome acquired resistance of cancer cells to selected strategies. In this regard, we can translate basic knowledge about taurine and its TUG1 lncRNA into potential therapeutic options directed against specific oncogenic signaling targets, thereby bridging the gap between bench and bedside. Contents 1. The role of taurine in inflammation 2. Formation of taurine haloamines 3. Anti-microbial properties of taurine haloamines 4. Anti-inflammatory and anti-oxidant properties of taurine haloamines 5. Therapeutic perspectives and clinical studies 6. Significance of lncRNA TUG1 lncRNA in cancer 7. The association of lncRNA TUG1 and chemoresistance 8. The role of taurine or lncRNA TUG1 as a prognostic marker 9. Conclusions

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Section: Therapeutic Perspectives and Clinical Studiesmentioning

confidence: 99%

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Baliou

Kyriakopoulos²,

Spandidos

et al. 2020

Int J Oncol

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“…The anti-inflammatory capacity of TauNHBr is highly associated with i) its capacity to hinder phagocyte function and to impair the respiratory burst (26); ii) the reduction of various pro-inflammatory mediators [tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-1β, IL-8 and IL-12], nitric oxide (NO), prostaglandin E 2 (PGE 2 ) and chemokines in both rodent and human leukocytes (27)(28)(29)(30)(31); iii) the inhibition of nuclear factor κB (NF-κB) activity (27); and iv) the induction of heme-oxygenase-1 (HO-1) expression in various cell types (3), including J774A.1 macrophages (Mφs) (32) or rheumatoid arthritis fibroblast-like synovial cells (33). From a clinical perspective, TauNHBr has been proven to be beneficial in the treatment of acne vulgaris (34), herpes zoster (35), in the local treatment of periodontal diseases, and in the elimination of oral biofilm pathogens (36).…”

Section: Bromamine T a Stable Active Bromine Compound Prevents The Lps-induced Inflammatory Responsementioning

confidence: 99%

Bromamine T, a stable active bromine compound, prevents the LPS‑induced inflammatory response

et al. 2021

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Inflammation is the most common cause of most acute and chronic debilitating diseases. Towards unveiling novel therapeutic options for patients with such complications, N-bromotaurine (TauNHBr) has emerged as a potential anti-inflammatory agent; however, its therapeutic efficacy is hindered due to its relatively poor stability. To address this challenge, the present study focused on examining the effects of a stable active bromine compound, named bromamine T (BAT). The present study examined the protective properties of BAT against lipopolysaccharide (LPS)-mediated inflammation in vitro , by using LPS-stimulated murine J774.A1 macrophages (Mφs), as well as in vivo , by using a murine LPS-mediated air-pouch model. Additionally, its efficacy was compared with that of taurine, a known potent anti-inflammatory molecule. In LPS-stimulated J774A.1 Mφs, BAT and taurine were very effective in reducing the secretion of pro-inflammatory mediators. The in vitro experiments indicated that LPS-mediated inflammation was attenuated due to the protective properties of BAT and of taurine, probably through the inhibition of phosphorylated p65 NF-κB subunit (Ser 536) nuclear translocation. The in vivo experiments also revealed that BAT and taurine inhibited LPS-mediated inflammation by reducing total cell/polymorphonuclear cell (PMN) infiltration in the air-pouch and by decreasing pouch wall thickness. The analysis of exudates obtained from pouches highlighted that the inhibitory effects of BAT and taurine on the secretion of pro-inflammatory cytokines were similar to those observed in vitro . Notably, the effect of BAT at the highest concentration tested was superior to that of taurine at the highest concentration. Taken together, the findings of the present study indicate that BAT prevents the LPS-induced inflammatory response both in vitro and in vivo .

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Comparative Analysis of Microbicidal and Anti-inflammatory Properties of Novel Taurine Bromamine Derivatives and Bromamine T

Walczewska

Peruń

Białecka³

et al. 2017

Advances in Experimental Medicine and Biology

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Taurine, the most abundant free amino acid in leukocyte cytosol traps hypohalous acids (HOCl and HOBr) to produce N-chlorotaurine (taurine chloramine, NCT and N-bromotaurine (taurine bromamine, Tau-NHBr,) respectively. Both haloamines show anti-inflammatory and antimicrobial properties. However, the therapeutic applicability of Tau-NHBr is limited due to its relatively poor stability. To overcome this disadvantage, we have synthesized the stable N-bromotaurine compounds N-monobromo-2,2-dimethyltaurine (Br-612) and N-dibromo-2,2-dimethyltaurine (Br-422). The aim of this study was to compare anti-inflammatory and microbicidal properties of Br-612 and Br-422 with that of Tau-NHBr and bromamine T (BAT). We have shown that all the tested compounds show similar anti-inflammatory properties. Importantly, the stable N-bromotaurine compounds exerted even stronger microbicidal activity than Tau-NHBr. Finally, for the purpose of topical application of these compounds we have developed a carbomer-based bioadhesive solid dosage form of BAT and Br-612, featuring sustained release of the active substance.

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Taurine Haloamines and Biofilm: II. Efficacy of Taurine Bromamine and Chlorhexidine Against Selected Microorganisms of Oral Biofilm

Cited by 4 publications

References 33 publications

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

Bromamine T, a stable active bromine compound, prevents the LPS‑induced inflammatory response

Comparative Analysis of Microbicidal and Anti-inflammatory Properties of Novel Taurine Bromamine Derivatives and Bromamine T

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