Susceptibility of mitochondrial superoxide dismutase to aluminium induced oxidative damage

POSSIBLE THERAPEUTIC ROLE OF <I>JASONIA CANDICANS</I> AND <I>JASONIA MONTANA</I> EXTRACTS IN THE REGRESSION OF ALZHEIMER’S DISEASE IN EXPERIMENTAL MODEL

“…Al has been shown to induce oxidative stress via production of ROS and this considered as one of the important mechanisms indicating that aluminum has an association with the etiology of Alzheimer's disease (Kumar et al, 2009b). Our results are in consistent with the previous findings, where 8-OHdG generation was significantly higher in rat administered AlCl 3 than that in the control one (Kumar et al, 2009b).…”

“…An increased production of superoxide radicals inside the mitochondria may oxidize DNA resulting in the formation of 8-OHdG that is the most commonly analyzed biomarker of DNA damage and the predominant adduct among oxidized bases (Dizdaroglu et al, 2000). Al has been shown to induce oxidative stress via production of ROS and this considered as one of the important mechanisms indicating that aluminum has an association with the etiology of Alzheimer's disease (Kumar et al, 2009b). Our results are in consistent with the previous findings, where 8-OHdG generation was significantly higher in rat administered AlCl 3 than that in the control one (Kumar et al, 2009b).…”

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

“…Aluminum has a strong prooxidant activity in spite of its non redox status [24]. Kumar et al [25] observed that Al exposure is associated with impairment of antioxidant defense system that may lead to oxidative stress. Also, Al could increase the activity of monoamine oxidase enzyme (MAO) in the brain which leads to increase generation of H 2 O 2 [26].…”

“…Munoz-Castaneda et al [34] showed that the lack of estrogen by ovariectomy induced a reduction of antioxidant status (GSH, SOD and GPx) and elevated lipid peroxides in rats. Aluminum exposure causes impairment of the antioxidant defense system that may lead to oxidative stress [25,35]. Aluminum causes brain damage via ROS more than any other organ because of high brain lipid content, high oxygen turnover, low mitotic rate as well as low antioxidant concentration [36].…”

“…Several melatonin metabolites that are generated when melatonin interacts with toxic reactants are themselves able to increase the efficiency of the electron transport chain in the inner mitochondrial membrane with a consequent impairment of free radical generation [37]. Kumar et al [25] reported that aluminum altered the cellular redox state of the brain by inhibiting antioxidant enzymes defense, such as SOD and catalase, which function as blockers of free radical. Increased activities of GPx and Cu-Zn SOD/Mn-SOD in the rat brain after exogenous administration of melatonin has been reported [38].…”