Toxicology and Biosafety Evaluations of Quantum Dots

Lin, Pinpin; Yang, Raymond H.S.; Yang, Chung‐Shi; Lin, Chia‐Hua; Chang, Louis W.

doi:10.1002/9783527610419.ntls0202

Cited by 2 publications

(1 citation statement)

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“…The commonly used QDs are cadmium based, and their toxicity is still a problem in biological applications [ 10 , 11 ]. Silicon (Si) is a well-studied material in the semiconductor family, which has attracted great attention because of its intrinsic advantages, such as low cost, strong fluorescence, high stability, and photostability.…”

Section: Introductionmentioning

confidence: 99%

Toxicological Evaluation of Luminescent Silica Nanoparticles as New Drug Nanocarriers in Different Cancer Cell Lines

et al. 2018

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Luminescent mesoporous silica nanoparticles, CdTeQDs@MNs@PEG1, SiQDs@Isoc@MNs and SiQDs@Isoc@MNs@PEG2, were successfully synthetized and characterized by SEM, TEM, XRD, N2 nitrogen isotherms, 1H NMR, IR, absorption, and emission spectroscopy. Cytotoxic evaluation of these nanoparticles was performed in relevant in vitro cell models, such as human hepatoma HepG2, human brain endothelial (hCMEC/D3), and human epithelial colorectal adenocarcinoma (Caco-2) cell lines. None of the tested nanoparticles showed significant cytotoxicity in any of the three performed assays (MTT/NR/ LDH) compared with the respective solvent and/or coating controls, excepting for CdTeQDs@MNs@PEG1 nanoparticles, where significant toxicity was noticed in hCMEC/D3 cells. The results presented reveal that SiQDs-based mesoporous silica nanoparticles are promising nanoplatforms for cancer treatment, with a pH-responsive drug release profile and the ability to load 80% of doxorubicin.

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Section: Introductionmentioning

confidence: 99%