Susceptibility of Clinical <i>Moraxella catarrhalis</i> Isolates in British Columbia to Six Empirically Prescribed Antibiotic Agents

Bandet, Tamara; Whitehead, Sue; Blondel-Hill, Edith; Wagner, Ken; Cheeptham, Naowarat

doi:10.1155/2014/370964

Cited by 18 publications

(10 citation statements)

References 13 publications

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“…Other antimicrobial agents, such as tetracycline, erythromycin, ciprofloxacin, and trimethoprim-sulfamethoxazole have also been empirically used to treat M. catarrhalis infections worldwide with apparent success. All clinical isolates collected in this study showed 100% susceptibility to tetracycline and erythromycin which is consistent with the most current international research [18]. Nevertheless, the antimicrobial resistance threat must keep the clinical community vigilant.…”

Section: Discussionsupporting

confidence: 87%

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

Hamzé

Osman²,

Mallat³

et al. 2019

int. arab. j antimicrob. agents

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Background. Moraxella catarrhalis is an important bacterial pathogen. Although national data have shown an increase in the levels of antimicrobial resistance in clinical settings in Lebanon, there is a lack of data regarding this human pathogen. This study aimed to determine for the first time the antimicrobial susceptibility profiles of M. catarrhalis isolates in Lebanon. Methods. A total of 34 M. catarrhalis strains were isolated from clinical specimens during the period from November 2010 to March 2019. Bacterial identification was carried out using matrix assisted laser desorption ionization–time of flight mass spectrometry. Antibiotic susceptibility of all isolates was performed according the recommendations of the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Results. A total of 34 non-duplicated M. catarrhalis strains were isolated from nose (n=19), ear (n=7), sputum (n=5), blood (n=1), eye (n=1), and throat (n=1) of patients referred to Nini Hospital in Tripoli, North governorate of Lebanon. Regarding antibiotic susceptibility rates, the percent susceptibility is 100% to the majority of antibiotics, except ampicillin (7.4%), trimethoprim-sulfamethoxazole (85.3%), nalidixic acid (85.3%), and ciprofloxacin (97.1%). Conclusion. To our knowledge, this study is the first investigation regarding the antimicrobial susceptibility patterns of M. catarrhalis isolates in Lebanon. In addition to the high level of resistance to ampicillin, our findings showed the emergence of resistance to trimethoprim-sulfamethoxazole, nalidixic acid and ciprofloxacin. Even if this study provides useful information to develop effective empirical treatment, we recommend the implementation of reliable diagnostic tools to guide appropriate treatment.

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Section: Discussionsupporting

confidence: 87%

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

Hamzé

Osman²,

Mallat³

et al. 2019

int. arab. j antimicrob. agents

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“…were sensitive to all antibiotics. A similar result was obtained by Bandet et al (2014) who reported that M. catarrhalis was susceptible to many of the antibiotics. On the other hand, Samuel et al (2019) stated that M. catarrhalis was highly resistant to ampicillin.…”

Section: Discussionsupporting

confidence: 86%

Monitoring and controlling bacteria in pharmaceutical industries water system

Selim

Saeed

Ibrahim

2020

J. Appl. Microbiol.

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Aim This research aimed to monitor pharmaceutical water system by sampling water from all treatment stages, identify bacterial isolates from each phase and determine the most suitable methods to control them. Methods and Results Water samples were collected and examined from pharmaceutical water system in a pharmaceutical factory in Giza, Egypt during 12 months, once per month (from December 2017 to November 2018) from 15 points covering all stages of the treatment process starting from wells, pre‐treatment points; treatment points ending with purified points which are the main source of water used in all pharmaceutical process. In all, 216 water samples were collected and examined, 156 isolates were selected according to morphological characteristics. VITEK system 2 (BioMérieux) was used for identification of all isolates resulting in 24 different identified bacteria. Antibiotic assay test using disc diffusion methods were carried out using seven antibiotics from different groups. Several disinfectants were also examined for efficacy against the isolates to control micro‐organisms in water treatment stage and manufacturing area. The effect of different preservatives (parabens, acids and alcohols) in various pharmaceutical formulas was also tested on bacterial isolates, 63% of formulas were effective against all bacterial isolates. Conclusion Ciprofloxacin was the most effective antibiotic, mixture of 0·45% peracetic acid plus 2·2% of hydrogen peroxide (Minncare 1%) was maximally effective disinfectant, and Cronobacter sakazakii was the most resistant micro‐organism against 22·7% of tested preservatives. Significance and Impact of the study Controlling pharmaceutical manufacturing operation from pathogenic bacteria that affect the quality of drugs.

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“…This is a source of confusion for clinicians. Previous reports documented high susceptibility rates of M. catarrhalis isolates to third- and fourth-generation cephalosporins (such as ceftriaxone and ceftazidime) and amoxicillin–clavulanic, at nearly 100% [ 9 , 11 – 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…Three antimicrobial resistance judgemnet criteria can be used to analyze the antibiotic susceptibility pattern of M. catarrhalis strains: the European Committee on Antimicrobial Susceptibility Testing (EUCAST), the Clinical and Laboratory Standards Institute (CLSI) [ 8 ], and the British Society for Antimicrobial Chemotherapy (BSAC) [ 9 ]; CLSI is most commonly used in China. Because of the lack of a unified testing method and judgemnet criteria for antibiotic resistance of M. catarrhalis , data from different areas show significant differences [ 10 , 11 ]. Moreover, susceptibility testing of M. catarrhalis is not routinely performed in most diagnostic laboratories, and many resistance data derive from large cities, with few studies conducted in more rural areas.…”

Section: Introductionmentioning

confidence: 99%

β-Lactamase production and antibiotic susceptibility pattern of Moraxella catarrhalis isolates collected from two county hospitals in China

et al. 2018

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BackgroundMoraxella catarrhalis (M. catarrhalis) is an important bacterial pathogen. However, its antibiotic susceptibility patterns in different areas are difficult to compare because of the use of different methods and judgement criteria. This study aimed to determine antimicrobial susceptibility and β-lactamase activity characteristics of M. catarrhalis isolates collected from two county hospitals in China, and to express the results with reference to three commonly used judgement criteria.ResultsNasopharyngeal swabs were obtained from child inpatients with respiratory tract infections at the People’s Hospital of Zhongjiang County and Youyang County from January to December 2015. M. catarrhalis strains were isolated and identified from the swabs, and susceptibility against 11 antimicrobials was determined using the E-test method or disc diffusion. Test results were interpreted with reference to the standards of the European Committee on Antimicrobial Susceptibility Testing (EUCAST), the Clinical and Laboratory Standards Institute (CLSI), and the British Society for Antimicrobial Chemotherapy (BSAC). Detection of β-lactamase activity was determined by the chromogenic cephalosporin nitrocefin. M. catarrhalis yield rates were 7.12 and 9.58% (Zhongjiang County, 77/1082 cases; Youyang County, 101/1054 cases, respectively). All isolates were susceptible to amoxicillin–clavulanic acid. The susceptibility rate to meropenem was 100% according to EUCAST; no breakpoints were listed in CLSI or BSAC. The non-susceptibility rate to sulfamethoxazole-trimethoprim differed significantly between the two hospitals regardless of the judgemnet criteria used, with isolates from Zhongjiang showing higher susceptibility to those from Youyang (Fisher’s exact test, P < 0.05). According to CLSI, the total non-susceptibility rate to erythromycin was 70.8% (Zhongjiang County, 79.2%; Youyang County, 64.3%), and the rate reached 92.1% (Zhongjiang County, 90.9%; Youyang County, 93.1%) on the basis of EUCAST or BSAC. The total positive rate of β-lactamase was 99.4% (177/178 cases) (Zhongjiang County, 100%, 77/77 cases; Youyang County, 99.0%, 100/101 cases).ConclusionsNinety nine percent of M. catarrhalis isolates produce β-lactamase. The isolates showed poor susceptibility to ampicillin and erythromycin, and high susceptibility to the third- and fourth-generation cephalosporins and amoxicillin–clavulanic. Significant discrepancies between different antimicrobial susceptibility judgemnet criteria were noted.

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Susceptibility of Clinical Moraxella catarrhalis Isolates in British Columbia to Six Empirically Prescribed Antibiotic Agents

Cited by 18 publications

References 13 publications

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

First data on antimicrobial susceptibility patterns of Moraxella catarrhalis isolates in Lebanon

Monitoring and controlling bacteria in pharmaceutical industries water system

β-Lactamase production and antibiotic susceptibility pattern of Moraxella catarrhalis isolates collected from two county hospitals in China

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