1998
DOI: 10.2307/3284643
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Susceptibility Differences to Cryptosporidium parvum Infection in Two Strains of Gamma Interferon Knockout Mice

Abstract: Differences in susceptibility to cryptosporidial infections were investigated between 2 strains of gamma interferon knockout (GKO) mice. Male C57BL/6J-Ifg and BALB/c-Ifg (GKO) mice, ages 8-10 wk, were inoculated with infectious oocysts at various doses. C57BL/6J-Ifg mice developed overwhelming infections and died 9-12 days after infection. Low inoculum doses (1 x 10(3)) did not increase the survival time significantly. The infection intensity in C57BL/6J-Ifg mice inoculated with 1 x 10(5) oocysts/mouse increas… Show more

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Cited by 71 publications
(65 citation statements)
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“…In murine models, IFN-␥ is a critical mediator of the innate and acquired immune responses controlling cryptosporidiosis (10,52,66,87). Similarly, severe Cryptosporidium-associated diarrhea has been described for HIV-negative individuals with IFN-␥ deficiency (28).…”
Section: Ifn-␥-dependent Immune Response and Cytokinesmentioning
confidence: 99%
“…In murine models, IFN-␥ is a critical mediator of the innate and acquired immune responses controlling cryptosporidiosis (10,52,66,87). Similarly, severe Cryptosporidium-associated diarrhea has been described for HIV-negative individuals with IFN-␥ deficiency (28).…”
Section: Ifn-␥-dependent Immune Response and Cytokinesmentioning
confidence: 99%
“…Studies suggest that in adaptive immunity to C. parvum, IFN-␥ and IL-12 also have protective roles in adult mice, indicating the involvement of Th1 responses (5,24). Ultimate control of infection in adult mice and humans is dependent on CD4 ϩ T cells (2,27), and IFN-␥ expression by these cells could be a key factor in host defense, although in humans, this cytokine might be more important during secondary infection (12,14,36).…”
mentioning
confidence: 99%
“…Some possibilities, not mutually exclusive, include a direct toxic effect of IFN-␥ on the parasite or the infected cells or the induction of other cytokines that can be toxic for the parasite or of chemoattractants for immune cells. Mead and You reported that susceptible BALB/c-GKO mice recover from infection whereas C57BL/6-GKO mice remain chronically infected (24), suggesting that other immune components related to the genetic background of the mice play a role in the susceptibility of mice to C. parvum infection.…”
mentioning
confidence: 99%