CD4<sup>+</sup>T Cells Are Not Essential for Control of Early Acute<i>Cryptosporidium parvum</i>Infection in Neonatal Mice

Korbel, Daniel S.; Barakat, Farah M.; Santo, James P. Di; McDonald, Vincent

doi:10.1128/iai.00922-10

Cited by 22 publications

(25 citation statements)

References 41 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A number of findings, however, cast uncertainty on a major protective function of T cells in the newborn mouse. For example, no increases in the percentages of CD4 + or CD8 + T cells in the Peyer's patches or lamina propria were observed during infection . No antigen‐specific activation of T cells was obtained in splenocytes taken from neonatal mice at different times during the patent infection period .…”

Section: Infections In Immunocompromised and Neonatal Micementioning

confidence: 99%

“…In addition, similar acute patterns of infection were observed in neonatal C57BL/6 wild type and Rag2 −/− mice. When adult wild type and Rag2 −/− mice previously infected as neonates were treated with an immunosuppressive drug, however, relapse of infection was observed only in Rag2 −/− mice . Even without treatment, relapse of infection that became fatal eventually occurred in most Rag2 −/− mice.…”

Section: Infections In Immunocompromised and Neonatal Micementioning

confidence: 99%

See 1 more Smart Citation

Innate immune responses against Cryptosporidium parvum infection

McDonald

Korbel

Barakat

et al. 2013

Parasite Immunology

View full text Add to dashboard Cite

Cryptosporidium parvum infects intestinal epithelial cells and is commonly the parasite species involved in mammalian cryptosporidiosis, a major health problem for humans and neonatal livestock. In mice, immunologically mediated elimination of C. parvum requires CD4+ T cells and IFN-γ. However, innate immune responses also have a significant protective role in both adult and neonatal mice. NK cells and IFN-γ have been shown to be important components in immunity in T and B cell-deficient mice, but IFN-γ-dependent resistance has also been demonstrated in alymphocytic mice. Epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate antimicrobial killing mechanisms, including production of NO and antimicrobial peptides. Toll-like receptors facilitate the establishment of immunity in mice and are involved in the development of inflammatory responses of infected epithelial cells and also dendritic cells.

show abstract

Section: Infections In Immunocompromised and Neonatal Micementioning

confidence: 99%

Section: Infections In Immunocompromised and Neonatal Micementioning

confidence: 99%

Innate immune responses against Cryptosporidium parvum infection

McDonald

Korbel

Barakat

et al. 2013

Parasite Immunology

View full text Add to dashboard Cite

show abstract

“…Because of the ‘minimally invasive’ nature of Cryptosporidium infection, mucosal epithelial cells are critical to the host’s anti- Cryptosporidium immunity. Indeed, a recent study with newborn mice showed similar acute patterns of C. parvum infection in C57BL/6 wild-type and T and B cell-deficient Rag2 −/− mice (Korbel et al 2011). Upon Crypto-sporidium infection, epithelial cells quickly initiate a series of innate immune reactions, including production of antimicrobial peptides (e.g.…”

Section: Mucosal Epithelial Cells Are Critical Players In the Host’s mentioning

confidence: 95%

Non-coding RNAs in epithelial immunity toCryptosporidiuminfection

2014

View full text Add to dashboard Cite

SUMMARY Cryptosporidium spp. is a protozoan parasite that infects the gastrointestinal epithelium and causes diarrhoeal disease worldwide. It is one of the most common pathogens responsible for moderate to severe diarrhoea in children younger than 2 years. Because of the ‘minimally invasive’ nature of Cryptosporidium infection, mucosal epithelial cells are critical to the host’s anti-Cryptosporidium immunity. Gastrointestinal epithelial cells not only provide the first and most rapid defence against Cryptosporidium infection, they also mobilize immune effector cells to the infection site to activate adaptive immunity. Recent advances in genomic research have revealed the existence of a large number of non-protein-coding RNA transcripts, so called non-coding RNAs (ncRNAs), in mammalian cells. Some ncRNAs may be key regulators for diverse biological functions, including innate immune responses. Specifically, ncRNAs may modulate epithelial immune responses at every step of the innate immune network following Cryptosporidium infection, including production of antimicrobial molecules, expression of cytokines/chemokines, release of epithelial cell-derived exosomes, and feedback regulation of immune homoeostasis. This review briefly summarizes the current science on ncRNA regulation of innate immunity to Cryptosporidium, with a focus on microRNA-associated epithelial immune responses.

show abstract

“…They are activated by IL-15 secreted by IECs, and have been shown to lyse C. parvum -infected IECs in response to IL-15 in vitro (62). Previous studies found that mice lacking functional NK cells were more susceptible to Cryptosporidium infection (63,64), while treatment of immunocompetent and immunodeficient mice with IL-12, a potent NK cell activator, enhanced protection (65). Both studies found that NK cell-dependent protection was primarily mediated through IFN-γ.…”

Section: Immune Responses To Cryptosporidiummentioning

confidence: 99%

Systemic and Mucosal Immune Responses to Cryptosporidium—Vaccine Development

Ludington

Ward

2015

Curr Trop Med Rep

View full text Add to dashboard Cite

Cryptosporidium spp is a major cause of diarrheal disease worldwide, particularly in malnourished children and untreated AIDS patients in developing countries in whom it can cause severe, chronic and debilitating disease. Unfortunately, there is no consistently effective drug for these vulnerable populations and no vaccine, partly due to a limited understanding of both the parasite and the host immune response. In this review, we will discuss our current understanding of the systemic and mucosal immune responses to Cryptosporidium infection, discuss the feasibility of developing a Cryptosporidium vaccine and evaluate recent advances in Cryptosporidium vaccine development strategies

show abstract

CD4⁺T Cells Are Not Essential for Control of Early AcuteCryptosporidium parvumInfection in Neonatal Mice

Cited by 22 publications

References 41 publications

Innate immune responses against Cryptosporidium parvum infection

Innate immune responses against Cryptosporidium parvum infection

Non-coding RNAs in epithelial immunity toCryptosporidiuminfection

Systemic and Mucosal Immune Responses to Cryptosporidium—Vaccine Development

Contact Info

Product

Resources

About

CD4+T Cells Are Not Essential for Control of Early AcuteCryptosporidium parvumInfection in Neonatal Mice

Cited by 22 publications

References 41 publications

Innate immune responses against Cryptosporidium parvum infection

Innate immune responses against Cryptosporidium parvum infection

Non-coding RNAs in epithelial immunity toCryptosporidiuminfection

Systemic and Mucosal Immune Responses to Cryptosporidium—Vaccine Development

Contact Info

Product

Resources

About

CD4⁺T Cells Are Not Essential for Control of Early AcuteCryptosporidium parvumInfection in Neonatal Mice