1975
DOI: 10.1128/aac.8.2.164
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Susceptibilities of Gram-Negative Bacteria to Combinations of Antimicrobial Agents In Vitro

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1976
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Cited by 12 publications
(6 citation statements)
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References 23 publications
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“…Consistently, in depth interaction studies by Leng, Meyers & Hirschman (1975) have reported similar findings against Gramnegative organisms and further demonstrated synergism against many Ε coli, Enterobacter sp, Klebsiella sp and Pseudomonas sp. Although antibacterial effectiveness is a prerequisite for clinical effectiveness, the ability of the cement to deliver active anti biotic will ultimately effect potential usability.…”
Section: Discussionsupporting
confidence: 65%
“…Consistently, in depth interaction studies by Leng, Meyers & Hirschman (1975) have reported similar findings against Gramnegative organisms and further demonstrated synergism against many Ε coli, Enterobacter sp, Klebsiella sp and Pseudomonas sp. Although antibacterial effectiveness is a prerequisite for clinical effectiveness, the ability of the cement to deliver active anti biotic will ultimately effect potential usability.…”
Section: Discussionsupporting
confidence: 65%
“…We could not verify preliminary reports made by various investigators regarding an impairment of the bactericidal activity of gentamicin by clindamycin against gram-negative bacilli. Our results are in accordance with those of Leng and co-workers (7) and thosepresented by Fass and co-workers (4), who showed that clindamycin did not interfere with the activity of gentamicin; however, we did not observe any instance of synergism between clindamycin and gentamicin.…”
supporting
confidence: 83%
“…Several in vitro studies reported additive or synergistic activity of clindamycin plus gentamicin against gram-positive and gram-negative microorganisms (2,3,7).…”
mentioning
confidence: 99%
“…It is known that the macrolide ERY shows only marginal activity against Gram-negative bacteria. Among clinical E. coli isolates, MICs ranging from 16 µg/ml to 1024 µg/ml have been reported [41][42] , whereas MICs range from 4 µg/ml to 150 µg/ml for lab strains 38,[43][44] . For the E. coli wildtype strain, we recorded a MIC of 32.9 µg/ml.…”
Section: Uptake Of Trimethoprim Tetracycline and Erythromycinmentioning
confidence: 99%