Survival of Patients With Neuroendocrine Carcinoma of the Colon and Rectum

Shafqat, Hammad; Ali, Shihab; Salhab, Mohamed; Olszewski, Adam J.

doi:10.1097/dcr.0000000000000298

Cited by 87 publications

(99 citation statements)

References 25 publications

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“…Specific data on GEP NEC are now emerging and the new understanding has shown that this is a specific disease entity. There has been an increase in the incidence of GEP NEC over the last 2 decades, although more awareness of this entity among pathologists could partly explain this increase [3,[8][9][10]. NEC can originate anywhere in the GEP tract, but they are mainly located in the esophagus, stomach, pancreas, and large bowel [7,[11][12][13][14].…”

mentioning

confidence: 99%

Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3)

et al. 2018

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Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) are classified based on morphology and graded based on their proliferation rate as either well-differentiated low-grade (G1 to G2) neuroendocrine tumors (NET) or poorly differentiated high-grade (G3) neuroendocrine carcinomas (NEC). Recently, a new subgroup of well-differentiated high-grade pancreatic tumors (NET G3) has been defined. The GEP NEN G3 group consisting of both NEC and NET G3 has recently been shown to be a quite heterogeneous patient group concerning prognosis and treatment benefit, depending on factors such as the primary tumor site, differentiation, proliferation rate, and molecular alterations. In this review we discuss the existing data on diagnostics, treatment, and biomarkers in this patient group, the unmet needs, and the future perspectives.

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confidence: 99%

Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3)

et al. 2018

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“…[22] Histologically HGNEC can also be either the small cell type or large cell type with some reports that large cell HGNEC may have a better prognosis. [23] Staging for localized and metastatic disease is the same as that for colorectal adenocarcinoma. CT chest abdomen and pelvis should be performed for distant staging.…”

Section: Managementmentioning

confidence: 99%

Hindgut Neuroendocrine Neoplasia

Smith

Nandakumar

2015

Indian J Surg Oncol

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“…Whereas surgery contributed to improved outcome in non G3-NEC patients, it failed in G3 patients [22, 23]. A few studies demonstrated that multimodal and neoadjuvant approaches might be beneficial for this specific group of patients [24, 25].…”

Section: Rectal Netsmentioning

confidence: 99%

Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need

Valle¹,

Dijkum

Sundín

et al. 2018

Neuroendocrinology

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The subject of colorectal neuroendocrine neoplasms (NENs), subdivided into well-differentiated NENs, termed neuroendocrine tumours (NETs; grade (G) 1 and 2), and poorly differentiated NENs, termed neuroendocrine carcinomas (NECs; G3) according to the 2010 World Health Organisation (WHO) classification, has arguably not had as much attention or study as NENs occurring in other sites. Colorectal NETs and NECs are however easier to study than many others since they are usually not difficult to remove and are increasingly detected because of intensified colorectal cancer screening and surveillance programmes. Colorectal NETs and NECs show site-specific heterogeneity with variable behaviour and different therapeutic options; these various aspects provide unique challenges. Because of bowel cancer screening programmes, colorectal NENs, like conventional adenocarcinomas, may be diagnosed at a stage that is associated with improved survival. In this article we intend to describe and define areas of unmet needs relating to the epidemiology, classification, pathology, diagnosis and therapy of colorectal NETs (including NETs G3), colorectal NECs, and finally, mixed adeno-neuroendocrine carcinomas (MANECs) by reviewing and discussing the relevant literature.

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Survival of Patients With Neuroendocrine Carcinoma of the Colon and Rectum

Cited by 87 publications

References 25 publications

Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3)

Unmet Needs in High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms (WHO G3)

Hindgut Neuroendocrine Neoplasia

Colorectal Neuroendocrine Neoplasms: Areas of Unmet Need

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