Hindgut Neuroendocrine Neoplasia

Smith, James D.; Nandakumar, Govind

doi:10.1007/s13193-015-0477-x

Cited by 4 publications

(6 citation statements)

References 25 publications

(36 reference statements)

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“…The most common site for neuroendocrine carcinoma is the gastrointestinal tract and pancreas. Gastrointestinal tract neuroendocrine carcinoma is divided based on the embryological origin, there is foregut, midgut, and hindgut [10]. Hindgut neuroendocrine tumor which includes tumors located in the left colon, rectum, and anus [10].…”

Section: Discussionmentioning

confidence: 99%

Rare Case Report: Colorectal Carsinoma in 13 Years Old Boy

Noor¹,

Dwihantoro²

2022

Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)

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Colorectal carcinoma is a malignant tumor, often found in adults and the elderly. One case was found in children, with an incidence of about 1% of neoplasms in children. The aim of the authors is to report the first case in the last 5 years of our institution, a 13-year-old patient with a major complaint of flatulence and defecation of blood mucus and weight loss. The patient previously went to medical staff but there was no change, then was referred to Sardjito General Hospital. On digital rectal examination, there are many lumps in the rectum. Examination of barium enema is carried out with results according to the picture of rectal carcinoma. Exploratory laparotomy was performed and desendent colon tumors were fixed in the rectum and left lateral abdominal wall. It was decided to do a permanent colostomy and follow up for 3 months. Colorectal carcinoma in 13-year-old men is a rare case. Family history with similar complaints is denied. Anatomic pathology examination revealed neuroendocrine carcinoma. Patients have a permanent colostomy because the tumour cannot be resected and chemotherapy. Patients were followed up for 3 months by tracking metastases. Colorectal carcinoma in children is a rare and often delayed diagnosis, and has a poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Rare Case Report: Colorectal Carsinoma in 13 Years Old Boy

Noor¹,

Dwihantoro²

2022

Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)

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“…Traditionally, the NENs were named after the site of origin, the most common being the gastrointestinal tract (GIT) and the pancreas—the gastroenteropancreatic NENs (GEP-NENs). These are again divided into the foregut, midgut, and hindgut NENs based on the embryological development of the GIT and the arterial supply [ 2 ]. Our case study pertains to hindgut NEN, specifically rectal high grade neuroendocrine carcinoma (HG-NEC).…”

Section: Discussionmentioning

confidence: 99%

“…Several organizations like the World Health Organization (WHO), the European Neuroendocrine Tumor Society (ENETS), the American Joint Committee on Cancer (AJCC), and the North American Neuroendocrine Tumor Society (NANETS) have proposed guidelines to arrive at a more specific classification system to accurately assess prognosis of these tumors [ 2 – 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…The World Health Organization (WHO) and the European Neuroendocrine Tumor Society (ENETS) both incorporate mitotic count and Ki-67 proliferation for the classification of gastroenteropancreatic NENs (GEP-NETs). For NENs of the lungs and thymus, the WHO includes mitotic count and assessment of necrosis [ 2 – 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…As shown in Table 1 , NENs may be classified based on their histopathology, cell differentiation, mitotic index, and immunohistochemistry into mainly two groups [ 2 – 8 ]: Well-differentiated neuroendocrine tumor (WD-NET): slow growing, mostly benign—staged by AJCC/ENETS systems. High grade neuroendocrine carcinoma (HG-NEC): poorly differentiated, invasive and highly metastatic—usually staged by AJCC.…”

Section: Discussionmentioning

confidence: 99%

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Neuroendocrine Cancer of Rectum Metastasizing to Ovary

Amin

Kumaran

Bharatnur

et al. 2016

Case Reports in Oncological Medicine

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Neuroendocrine carcinomas (NECs) are rare malignancies that originate from the hormone-producing cells of the body's neuroendocrine system. Rectal high grade NEC (HG-NEC) constituting less than 1% of colorectal cancers can cause large ovarian metastasis that may be the initial presenting complaint. Ovarian Krukenberg tumor from a primary rectal HG-NEC is a very unusual and exceedingly uncommon differential diagnosis for secondary ovarian malignancy. This case report describes one such extremely rare case of a woman who had presented to the gynecology department with features suggestive of ovarian malignancy and was ultimately diagnosed to have Krukenberg tumor originating from neuroendocrine cancer of rectum. We felt this is a good opportunity to spread more light on neuroendocrine neoplasms that are very rare in gynecological practice.

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