Survival After Free Flap Reconstruction in Patients With Advanced Oral Squamous Cell Carcinoma

The recurrence and survival of oral squamous cell carcinoma: a report of 275 cases

“…Our results showed that the application of flap repair significantly reduced local tumor recurrence. de Vicente et al [6] have followed up 98 patients with OSCC. They found that the mortality was 47.0% in patients with flap repair and was 67.3% in patients without flap repair ( P < 0.05).…”

Improved overall survival and mortality in head and neck cancer with adjuvant concurrent chemoradiotherapy in national databases

“…Various improvements in RT and chemotherapy regimens may have also had an impact on overall survival; however, the addition of postoperative chemotherapy is the only major shift in treatment in recent years. Modern surgical techniques allow reconstruction of more extensive defects, which could improve survival by allowing extirpative surgery in otherwise nonoperable patients or improving margin control in more extensive resections; however, the currently available literature is both limited and conflicting . We propose that the improvement in overall survival reflected in the national databases is at least partially because of the implementation of adjuvant CRT as a standard treatment option.…”

Microsurgical Reconstruction of the Oral Cavity and Oropharynx After Cancer Ablation

“…In univariate analysis, compromised surgical margins and recurrence were significant for survival in the free flap group. At final analysis, the modality of reconstruction was not significant but showed a trend toward better survival (de Vicente et al, 2011). The impact of free flap was more evident in a retrospective study of 773 patients with oral squamous cell carcinoma.…”