Survey of Iranian Plants for Saponins, Alkaloids, Flavonoids and Tannins. II

Aynehchi, Y.; Sormaghi, M H Salehi; Amin, Gholamreza; Soltani, Ahmad; Qumehr, N.

doi:10.3109/13880208209083290

Cited by 18 publications

(5 citation statements)

References 3 publications

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“…A review of the phytochemical literature on T. parthenium revealed that this species is known to contain at least 30 sesquiterpenes, 11 monoterpenes, 6 spirofurans, and 1 flavonoid (13, [30][31][32][33][34][35][36][37][38][39]. Of these, in addition to parthenolide, four sesquiterpene lactones, 3-ß-hydroxyparthenolide, rere-tanapartholide A, canin, and artecanin, have been reported to inhibit 5-FIT release from human platelets (13).…”

Section: Resultsmentioning

confidence: 99%

A Bioassay for Inhibition of Serotonin Release from Bovine Platelets

Marles¹,

Kaminski²,

Arnason³

et al. 1992

J. Nat. Prod.

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A bioassay was developed to study agents capable of inhibiting the release of serotonin from bovine blood platelets. It is a simple, inexpensive, and reproducible high-throughput bioassay suitable for quality control of feverfew, Tanacetum parthenium, a crude drug with proven migraine prophylactic activity that is being considered for governmental registration and regulation. The bioassay, which requires no experimental animals or human subjects, was used to assess the in vitro activity of T. parthenium samples grown from seed obtained from 10 different regions of Europe. The activity was found to vary significantly within and between samples, with no geographical correlation. Serotonin release inhibition was shown to be significantly correlated with the content of the germacranolide sesquiterpene lactone, parthenolide, although other sesquiterpene lactones from this plant and other members of the Asteraceae were also shown to be active. The activities of six other species of Tanacetum, as well as of Artemisia absinthium (wormwood) and Zingiber officinale (ginger), and two commercial drugs for migraine prophylaxis, verapamil hydrochloride and propranolol hydrochloride, were also assessed. The relevance of the bovine platelet serotonin release inhibition bioassay to antimigraine research is discussed.

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Section: Resultsmentioning

confidence: 99%

A Bioassay for Inhibition of Serotonin Release from Bovine Platelets

Marles¹,

Kaminski²,

Arnason³

et al. 1992

J. Nat. Prod.

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“… Note . References are numbered as follows: 1 (Megdiche‐Ksouri et al, ), 2 (Ascensäo & Pais, ), 3 (Naili, Alghazeer, Saleh, & Al‐Najjar, ), 4 (Al‐Snafi, ), 5 (Lellau & Liebezeit, ), 6 (Charkhpour, Delazar, Mohammadi, Gholikhani, & Parvizpur, ), 7 (Willaman & Schubert, ), 8 (Kinney & Sugihara, ), 9 (Rätsch, ), 10 (Ahameethunisa & Hopper, ), 11 (Pradeep & Rengaswamy, ), 12 (Arokiyaraj et al, ), 13 (Judžentienė & Buzelytė, ), 14 (Haniya & Padma, ), 15 (Pires, Fulvio, Negri, Duarte‐Almeida, & Elisaldo, ), 16 (Ikram et al, ), 17 (Bhakuni, Jain, Sharma, & Kumar, ), 18 (Suresh, Ahuja, Paramakrishnan, & Sebastian, ), 19 (Feyera, Terefe, & Shibeshi, ), 20 (Lone, Bhat, & Khuroo, ), 21 (Sivagnanam, Rao, Mudiganti, & Jeelani, ), 22 (Wright, ), 23 (Suresh et al, ), 24 (Heo et al, ), 25 (Ruwali, Ambwani, Gautam, & Thapliyal, ), 26 (Corsi & Nencioni, ), 27 (Pala, Shukla, Alok, Kudale, & Desai, ), 28 (Kim, Adesogan, & Ko, ), 29 (Ali, Shah, & Shah, ), 30 (Choi, Kang, & Kim, ), 31 (Kim et al, ), 32 (Kristiani et al, ), 33 (Salhi et al, ), 34 (Aynehchi, Salehi Sormaghi, Amin, Khoshkhow, & Shabani, ), 35 (Fazly Bazzaz, Haririzadeh, Imami, & Rashed, ), 36 (Kapustina et al, ), 37 (Darwish‐Sayed, El‐Shamy, Hassan, & El‐Shahrawy, ), 38 (Pirbalouti, Firoz nezhad, Craker, & Akbarzadeh, ), 39 (Ene, Atawodi, Ameh, Kwanashie, & Agomo, ), 40 (Yan et al, ), 41 (Khatoon, ), 42 (Aynehchi et al, ), 43 (Noori, Amjad, & Yazdani, ), 44 (Elsharkawy & Shiboob, ), and 45 (Goodson, ).…”

Section: Introductionmentioning

confidence: 99%

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

Rashid

Alamzeb²,

Ali³

et al. 2019

Phytotherapy Research

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Several reviews have been published on Artemisia's derived natural products, but it is the first attempt to review the chemistry and pharmacology of more than 80 alkaloids and allied nitrogen compounds obtained from various Artemisia species (covering the literature up to June 2018). The pharmacological potential and unique skeleton types of certain Artemisia's alkaloids provoke the importance of analyzing Artemisia species for bioactive alkaloids and allied nitrogen compounds. Among the various types of bioactive Artemisia's alkaloids, the main classes were the derivatives of rupestine (pyridine–sesquiterpene), lycoctonine (diterpene), pyrrolizidine, purines, polyamine, peptides, indole, piperidine, pyrrolidine, alkamides, and flavoalkaloids. The rupestine derivatives are Artemisia's characteristic alkaloids, whereas the rest are common alkaloids found in the family Asteraceae and chemotaxonomically links the genus Artemisia with the tribes Anthemideae. The most important biological activities of Artemisia's alkaloids are including hepatoprotective, local anesthetic, β‐galactosidase, and antiparasitic activities; treatment of angina pectoris, opening blocked arteries, as a sleep‐inducing agents and inhibition of HIV viral protease, CYP450, melanin biosynthesis, human carbonic anhydrase, [3H]‐AEA metabolism, kinases, and DNA polymerase β1. Some of the important nitrogen metabolites of Artemisia include pellitorine, zeatin, tryptophan, rupestine, and aconitine analogs, which need to be optimized and commercialized further.

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“…& Reut. —The occurrence of saponins in O. anatolica was mentioned by Aynehchi et al [Iran; whole plant] [host species not mentioned] but no further specification of structures nor of any analytical methods were indicated in the report [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

Genuine and Sequestered Natural Products from the Genus Orobanche (Orobanchaceae, Lamiales)

Scharenberg

Zidorn

2018

Molecules

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The present review gives an overview about natural products from the holoparasitic genus Orobanche (Orobanchaceae). We cover both genuine natural products as well as compounds sequestered by Orobanche taxa from their host plants. However, the distinction between these two categories is not always easy. In cases where the respective authors had not indicated the opposite, all compounds detected in Orobanche taxa were regarded as genuine Orobanche natural products. From the about 200 species of Orobanche s.l. (i.e., including Phelipanche) known worldwide, only 26 species have so far been investigated phytochemically (22 Orobanche and four Phelipanche species), from 17 Orobanche and three Phelipanche species defined natural products (and not only natural product classes) have been reported. For two species of Orobanche and one of Phelipanche dedicated studies have been performed to analyze the phenomenon of natural product sequestration by parasitic plants from their host plants. In total, 70 presumably genuine natural products and 19 sequestered natural products have been described from Orobanche s.l.; these form the basis of 140 chemosystematic records (natural product reports per taxon). Bioactivities described for Orobanche s.l. extracts and natural products isolated from Orobanche species include in addition to antioxidative and anti-inflammatory effects, e.g., analgesic, antifungal and antibacterial activities, inhibition of amyloid β aggregation, memory enhancing effects as well as anti-hypertensive effects, inhibition of blood platelet aggregation, and diuretic effects. Moreover, muscle relaxant and anti-spasmodic effects as well as anti-photoaging effects have been described.

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Survey of Iranian Plants for Saponins, Alkaloids, Flavonoids and Tannins. II

Cited by 18 publications

References 3 publications

A Bioassay for Inhibition of Serotonin Release from Bovine Platelets

A Bioassay for Inhibition of Serotonin Release from Bovine Platelets

The chemistry and pharmacology of alkaloids and allied nitrogen compounds fromArtemisiaspecies: A review

Genuine and Sequestered Natural Products from the Genus Orobanche (Orobanchaceae, Lamiales)

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