Survey of fatalities from skin testing and immunotherapy 1985–1989

Reid, Michael; Lockey, Richard F.; Turkeltaub, Paul C.; Platts‐Mills, Thomas A.E.

doi:10.1016/0091-6749(93)90030-j

Cited by 348 publications

(207 citation statements)

References 24 publications

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“…The waiting period following injection has been set at 30 minutes, because most untoward reactions tend to be immediate. 17,30 In our series, most adverse effects occurred after SLIT with house dust mites, and 53.8% of reactions occurred during the build-up phase, underscoring the critical clinical point represented by this stage of SLIT. All but 1 reaction occurred within 60 minutes of administration, suggesting another critical clinical phase.…”

Section: Discussionsupporting

confidence: 53%

Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years

Fiocchi¹,

Pajno

Grutta³

et al. 2005

Annals of Allergy, Asthma & Immunology

113

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Background:The minimum age to start specific immunotherapy with inhalant allergens in children has not been clearly established, and position papers discourage its use in children younger than 5 years.Objective: To assess the safety of high-dose sublingual-swallow immunotherapy (SLIT) in a group of children younger than 5 years.Methods: Sixty-five children (51 boys and 14 girls; age range, 38 -80 months; mean Ϯ SD age, 60 Ϯ 10 years; median age, 60 months) were included in this observational study. They were treated with SLIT with a build-up phase of 11 days, culminating in a top dose of 300 IR (index of reactivity) and a maintenance phase of 300 IR 3 times a week. The allergens used were house dust mites in 42 patients, grass pollen in 11 patients, olive pollen in 5 patients, Parietaria pollen in 4 patients, and cypress pollen in 3 patients. All adverse reactions and changes in the treatment schedule were compared in 2 subgroups: children 38 to 60 months old and children 61 to 80 months old.Results: The average cumulative dose of SLIT was 36,900 IR. Adverse reactions were observed in 11 children, none of them severe enough to require discontinuation of immunotherapy. Six reactions occurred in the 60 months or younger age group and 7 in the older than 60 months age group, with no differences between these 2 groups.Conclusion: High-dose immunotherapy in children younger than 5 years does not cause more adverse reactions than in children aged 5 to 7 years. There is no reason to forbear studies on safety and efficacy of these preparations in young children.Ann Allergy Asthma Immunol. 2005;95:254-258.

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Section: Discussionsupporting

confidence: 53%

Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years

Fiocchi¹,

Pajno

Grutta³

et al. 2005

Annals of Allergy, Asthma & Immunology

113

View full text Add to dashboard Cite

show abstract

“…It is important to distinguish between annoying, but harmless reactions such as rhinitis, asthma, and urticaria responding well to treatment, and severe life-threatening anaphylactic reactions (2). Deaths have been caused by immunotherapy (81), and although most deaths were due to ignoring safety instructions and, especially, inadequate early treatment of anaphylactic shock, they serve as a warning not to perform immunotherapy without strict monitoring of safety (82). Nonspecific reactions, such as excessive tiredness and headache, and extremely rare symptoms consistent with immune complex disease have been reported.…”

Section: Side-effectsmentioning

confidence: 99%

Immunotherapy as an effective tool in allergy treatment

Mailing¹

1998

Allergy

154

100

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“…The potential side effects of anaphylaxis in SCIT largely restricted its clinical application, mainly because of the concerns about its safety raised by patients as well as doctors. And the treatment of SCIT should be performed at hospitals with well-trained nurses and doctors, as well as enough space and complete equipment in the case of a need for an anaphylaxis rescue, even if the probability is less than one of two million or two million eight hundred thousand (Reid et al, 1993). That could explain why provincial hospitals have the highest percentage of SCIT, and no district hospitals prescribe it.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of allergic diseases in Zhejiang Province: A cross-sectional survey

Wang

Shen

Yang

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Background: The specialty of allergy developed quickly in western countries because of the rapid increase of allergic diseases, whereas it developed relatively slowly in China. The prevalence of allergen sensitization and allergic diseases in Zhejiang Province of China is high and improving the medical services for these diseases is critically needed. Objective: To investigate the working status of the diagnosis and treatment of allergic diseases, including doctor resources, diagnostic methods, and allergen-specific immunotherapy in patients of Zhejiang Province, and to provide instructions for the strategic development of subspecialties of allergic diseases. Methods: First we defined the doctors who treat allergic diseases, and designed a comprehensive questionnaire to collect personal and hospital information for these doctors. The questionnaires were distributed to hospitals with different ranks and from different areas in the province. The general condition of doctor's resources, carryout of diagnostic methods, and allergen-specific immunotherapy were described and variations in the different specialties, hospitals, and areas were further analyzed. Results: Doctors in their thirties with bachelor's degrees were the mainstream for diagnosing and treating allergic diseases. The main specialties of the doctor resources were the specialties of Ear, Nose and Throat (ENT), Respirology, Pediatrics, and Dermatology. The Pediatrics specialty had a more reasonable infrastructure of doctor resources with more young doctors working in this subspecialty. The development of allergy subspecialty varied within hospitals at different levels or from different areas. The carryout of the skin prick test (SPT), serum specific IgE (ssIgE), and subcutaneous immunotherapy (SCIT) was best performed in provincial hospitals, while sublingual immunotherapy (SLIT) was prescribed most commonly in municipal hospitals. The performance of SPT and ssIgE in Hangzhou, Jiaxing, and Wenzhou areas was much better than that in other places. The performance of SCIT and SLIT was best in Wenzhou. Conclusions: Our survey revealed a very initial and unbalanced development for the allergy subspecialty in Zhejiang Province. Doctor resources for allergic diseases were mainly from the specialties of ENT, Respirology, and Pediatrics, and the performance of diagnosis and treatment was mainly focused on provincial and municipal hospitals. Continuous education of allergies could be extended to primary healthcare centers and more efforts should be directed to those areas with poor medical resources.

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Survey of fatalities from skin testing and immunotherapy 1985–1989

Cited by 348 publications

References 24 publications

Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years

Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years

Immunotherapy as an effective tool in allergy treatment

Diagnosis and treatment of allergic diseases in Zhejiang Province: A cross-sectional survey

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