Surgical Treatment of Metastatic Ovarian Tumors From Extragenital Primary Sites

Sal, Veysel; Demirkıran, Fuat; Topuz, Samet; Kahramanoğlu, İlker; Yalçın, İbrahim Ertuğrul; Beşe, Tugan; Sözen, Hamdullah; Tokgözoğlu, Nedim; Salihoğlu, Yavuz; Turan, Hasan; Iyibozkurt, Cem; Kolomuc, Tugba; Sofiyeva, Nigar; Berkman, Sinan; Arvas, M.

doi:10.1097/igc.0000000000000673

Cited by 20 publications

(16 citation statements)

References 10 publications

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“…Moreover, the prognosis of STOs that originate from a previously diagnosed malignancy is considerably better than in tumors presenting primarily as ovarian metastases. Several prognostic factors have been identified: pre-operative carbohydrate antigen 125 (CA 125) level in serum, age at diagnosis of STOs, pre-operative STO size [ 21 ], primary tumor origin [ 9 ], presence of peritoneal dissemination [ 20 ], extent of cytoreductive surgery [ 16 , 22 ], and unilaterality versus bilaterality [ 21 ]. Furthermore, mutations of the SMAD family member 4 ( SMAD4 ) and lysine methyltransferase 2D ( KMT2D ) genes are associated with reduced OS in ovarian metastases from CRC [ 23 ], indicating that somatic mutation profiling may provide additional prognostic information.…”

Section: Prognosismentioning

confidence: 99%

The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review

Kubeček

Laco

Špaček

et al. 2017

Clin Exp Metastasis

127

109

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Secondary tumors of the ovary account for 10–25% of all ovarian malignancies. The most common tumors that give rise to ovarian metastases include breast, colorectal, endometrial, stomach, and appendix cancer. The correct diagnosis of secondary ovarian tumors may be challenging as they are not infrequently misdiagnosed as primary ovarian cancer, particularly in the case of mucinous adenocarcinomas. The distinction from the latter is essential, as it requires different treatment. Immunohistochemistry plays an important role in distinguishing primary ovarian tumors from extra-ovarian metastases and, furthermore, may suggest the primary tumor site. Despite extensive study, some cases remain equivocal even after assessing a broad spectrum of antigens. Therefore, gene expression profiling represents an approach able to further discriminate equivocal findings, and one that has been proven effective in determining the origin of cancer of unknown primary site. The available data concerning secondary ovarian tumors is rather limited owing to the relative heterogeneity of this group and the practical absence of any prospective trials. However, several intriguing questions are encountered in daily practice, including rational diagnostic workup, the role of cytoreductive surgery, and consequent adjuvant chemotherapy. This review seeks to address these issues comprehensively and summarize current knowledge on the epidemiology, pathogenesis, and management of secondary ovarian tumors, including further discussion on the different pathways of metastatisation, metastatic organotropism, and their possible molecular mechanisms.

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Section: Prognosismentioning

confidence: 99%

The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review

Kubeček

Laco

Špaček

et al. 2017

Clin Exp Metastasis

127

109

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“…Research by several authors indicates that the average size of resected liver metastases varies between 4.5 cm and 5 cm. 5,10,14,15 In addition, Sal et al reported that 41% of the resections included liver metastases of >10 cm in diameter. 15 No differences have been demonstrated between the size of liver lesions according to their origin (parenchymal or peritoneal).…”

Section: Discussionmentioning

confidence: 99%

“…5,10,14,15 In addition, Sal et al reported that 41% of the resections included liver metastases of >10 cm in diameter. 15 No differences have been demonstrated between the size of liver lesions according to their origin (parenchymal or peritoneal). 1 The current authors found no significant difference between the mean sizes of liver metastases.…”

Section: Discussionmentioning

confidence: 99%

“…Minor liver resections were the most-frequently performed operations in the current series; similar results were found by other researchers. 1,3,15 In contrast, anatomical liver resections seem to have a small role in the management of advanced ovarian cancer; however, this is yet to be established. A free liverresection margin does not seem to influence the outcome of these particular patients according to the concept of optimal cytoreduction for ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

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Liver Resection as Part of Cytoreductive Surgery for Ovarian Cancer

Luna‐Abanto

Ruiz

Martínez

et al. 2020

Journal of Gynecologic Surgery

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Objective: The aim of this study was to describe and evaluate the safety of hepatic resections for ovarian cancer liver metastases and the benefit in terms of survival as part of cytoreductive surgery among peritoneal seeding and parenchymal metastases. Materials and Methods: Data were reviewed retrospectively from patients who underwent liver resection as part of cytoreductive surgery for ovarian cancer at the Instituto Nacional de Enfermedades Neoplásicas, in Lima, Perú, patients underwent surgical cytoreduction for ovarian cancer; 39 of these patients had liver resection as part of their surgical treatment, with 9, 17, and 13 patients receiving primary, secondary, and tertiary, resections, respectively. The mean age of the patients was 46, the majority (87%) had stage III/IV ovarian cancer. In addition, 21 patients had parenchymal metastasis resections, and 95% of the patients had Dindo-Clavien I and II grade complications. The 30-day mortality rate was 0. Conclusions: Liver resection for advanced ovarian cancer is a safe procedure for primary up to quaternary cytoreduction and may confer survival benefits to patients. ( J GYNECOL SURG 36:70)

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“…Despite the fact that the normal appearance of gastro intestinal system and pancreas, increased levels of CA 19.9 (1782.7 U/mL) is remarkable in our case and appropriate with isolated ovarian metastasis. Besides it has been reported that elevated levels of CA 19.9 is correlated with poor prognosis and advanced stage disease ( 6 ) . The metastasis rate from the biliary tumors to the ovaries is very low in the current literature ( 1 ) .…”

Section: Discussionmentioning

confidence: 99%

Bilateral ovarian metastasis of a Klatskin tumor: A rare case

Kurt

Ulukuş

Kazaz

et al. 2016

tjod

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Metastatic carcinomas of the ovary have an important place in all ovarian cancers and tumors. They can originate from many organs and systems and may metastasize to the ovary. The most common primary origin of metastasis is the gastrointestinal tract and then breast tissue. Cholangiocellular carcinomas involving the junction of the right and left bile ducts are called Klatskin tumors, and their metastases to the ovaries are very rare. A woman aged 54 years who had been treated previously for Klatskin tumor was admitted to our clinic due to bilateral ovarian masses and high serum calcium 19-9 levels. The preoperative approach, operative, and postoperative management of Klatskin tumor is presented.

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Surgical Treatment of Metastatic Ovarian Tumors From Extragenital Primary Sites

Cited by 20 publications

References 10 publications

The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review

The pathogenesis, diagnosis, and management of metastatic tumors to the ovary: a comprehensive review

Liver Resection as Part of Cytoreductive Surgery for Ovarian Cancer

Bilateral ovarian metastasis of a Klatskin tumor: A rare case

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