Liver Resection as Part of Cytoreductive Surgery for Ovarian Cancer

Luna‐Abanto, Jorge; Ruiz, Luis García; Martínez, J.L. Quesada; Larraondo, M Alvarez; Terrones, Vladimir Villoslada

doi:10.1089/gyn.2019.0074

Cited by 5 publications

(9 citation statements)

References 25 publications

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“…However, studies have shown that performing cytoreductive surgery, including hysterectomy, bilateral salpingo-oophorectomy, omentum resection, and resection of all metastatic lesions, is beneficial to the survival of patients ( 13 ). Performing complete resection of liver metastases can confer benefits to survival ( 14 ). A patient’s disease-free survival and overall survival improve ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

A clinical model to predict the risk of liver metastases in newly diagnosed ovarian cancer: a population-based study

Yuan¹,

Wang²,

Guo³

et al. 2020

Transl Cancer Res TCR

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Background: Liver metastases are important in determining the prognosis of ovarian cancer. We aimed to develop and validate nomograms to predict the risk of liver metastases in patients with early-stage ovarian cancer.Methods: A total of 13,487 patients were enrolled in the study based on their records in the Surveillance, Epidemiology, and End Results (SEER) database. Risk factors of liver metastases were assessed based on univariable and multivariable logistic regression. A nomogram was also formulated based on the results of multivariable logistic analysis. The area under the receiver-operating characteristic curve was calculated to evaluate the discrimination abilities of the metastasis-related factors and liver metastases nomogram. A calibration plot was generated to analyze the consistency between the observed probability and predicted probability of liver metastases in patients with ovarian cancer.Results: Four related factors were determined based on univariable and multivariable logistic regression, including the T1 stage, N1 stage, and presence of lung and bone metastases. The liver metastases nomogram composed of four features could be used to determine the prediction effect. The calibration plot showed good consistency between the nomogram prediction and actual observation. The receiver-operating characteristic curve showed that the forecast nomogram exhibited a good forecast value.Conclusions: This clinical prediction model has high accuracy to identify patients with newly diagnosed ovarian cancer who carry a high risk of liver metastases and provide a personalized treatment plan for these patients.

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Section: Discussionmentioning

confidence: 99%

A clinical model to predict the risk of liver metastases in newly diagnosed ovarian cancer: a population-based study

Yuan¹,

Wang²,

Guo³

et al. 2020

Transl Cancer Res TCR

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show abstract

“…Of these, 28 studies were subsequently excluded after the examination of full text (if available); in details, one because only the abstract was retrieved, three for language different from English and 24 because they didn't meet the population and intervention inclusion criteria of this study. Finally, 10 articles were included in our systematic review [17,[19][20][21][22][23][24][25][26][27] (Fig. 1).…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…All data about general characteristics and liver metastases characteristics and their surgical treatment are reported in Tables 1 (Ref. [13,[15][16][17][18][19][20][21][22][23]) and 2 (Ref. [13,[15][16][17][18][19][20][21][22][23]), respectively.…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…[13,[15][16][17][18][19][20][21][22][23]) and 2 (Ref. [13,[15][16][17][18][19][20][21][22][23]), respectively.…”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

“…Age was not reported in three articles [20,23,25] and only for 34 patients age was available; in this group the weighted average age was 57 years old. The histology of the disease was not reported in four studies [20,21,23,25] and hence was available in 32 patients as follow: 25 cases of serous ovarian cancer, 1 case of endometrial ovarian cancer,1 case of mucinous ovarian cancer, and 5 other types of tumours; these included 1 Mesonephric-like adenocarcinoma (M-LAC), 1 Tubular and trabecular type, 1 mixed epithelial cancer and 2 not specified in the detail. The type of treatment was available in 32 patients, while in four studies these data was not reported [20,21,23,25]; we identified 21 women who underwent PDS (66%) and 11 patients who received IDS (34%).…”

Section: General Patients' Characteristics Disease and Surgery Featuresmentioning

confidence: 99%

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Liver surgery for advanced ovarian cancer: a systematic review of literature

2022

EJGO

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To analyze the surgical treatment of liver metastases from advanced ovarian cancer (AOC) during either primary or interval debulking surgery (PDS or IDS). Data sources, methods of study selection: A systematic research of the literature was conducted in Scopus, PubMed/MEDLINE, ScienceDirect and the Cochrane Library, including observational prospective, retrospective studies, case series and case reports. Tabulation, integration and results: We collected data regarding study features, characteristics of the patients and of liver metastasis, the type of surgical treatment and postoperative morbidity. The type of liver surgery was described according to the terminology of Brisbane 2000 (TB2000). Ten articles were selected, and 61 patients were included, even though data was not complete for all of them. The weighted average age was 57 years old, and most women underwent PDS (n = 21/32 [66%]). The number of liver metastases was available only for 17 patients including 3 (18%) and 14 (82%) with multiple and single lesions, respectively. Metastasis from peritoneal seeding (peritoneal metastasis) was the most common type of lesion (n = 27/42 [64%]). Only in one study the authors declared the specialty of the surgeon performing the procedures (hepatobiliary). Two studies (n = 15) adopted the TB2000 and reported as follow: 47% wedge resections, 33% segmentectomies, 13% hemi-hepatectomies and 7% right-trisegmentectomy. Clavien-Dindo grade III or greater complications was 13% (n = 2/15). Conclusions: Liver resection is feasible during either PDS or IDS. Single lesion and peritoneal metastasis represent the most common conditions. Wedge liver resection is the most frequent procedure. Prognostic advantage is suggested after liver surgery especially for peritoneal metastasis.

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Upper-Abdominal Cytoreduction for Advanced Ovarian Cancer—Therapeutic Rationale, Surgical Anatomy and Techniques of Cytoreduction

Bhandoria

Bhatt

Mehta

et al. 2022

Surgical Techniques Development

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Cytoreductive surgery (CRS) is the cornerstone of treating advanced ovarian cancer. Approximately 60–70% of patients with advanced ovarian cancer will have involvement in the upper abdomen or the supracolic compartment of the abdominal cavity. Though the involvement of this region results in poorer survival compared, complete cytoreduction benefits overall survival, making upper-abdominal cytoreduction an essential component of CRS for advanced ovarian cancer. The upper abdomen constitutes several vital organs and large blood vessels draped with the parietal or visceral peritoneum, common sites of disease in ovarian cancer. A surgeon treating advanced ovarian cancer should be well versed in upper-abdominal cytoreduction techniques, including diaphragmatic peritonectomy and diaphragm resection, lesser omentectomy, splenectomy with or without distal pancreatectomy, liver resection, cholecystectomy, and suprarenal retroperitoneal lymphadenectomy. Other procedures such as clearance of the periportal region, Glisson’s capsulectomy, clearance of the superior recess of the lesser sac, and Morrison’s pouch are essential as these regions are often involved in ovarian cancer. This manuscript covers the surgical anatomy of the upper abdomen, the techniques and therapeutic rationale of upper-abdominal cytoreduction, and specific measures for perioperative management of these patients. The main focus is the description of various peritonectomies and regional lymphadenectomies.

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Liver Resection as Part of Cytoreductive Surgery for Ovarian Cancer

Cited by 5 publications

References 25 publications

A clinical model to predict the risk of liver metastases in newly diagnosed ovarian cancer: a population-based study

A clinical model to predict the risk of liver metastases in newly diagnosed ovarian cancer: a population-based study

Liver surgery for advanced ovarian cancer: a systematic review of literature

Upper-Abdominal Cytoreduction for Advanced Ovarian Cancer—Therapeutic Rationale, Surgical Anatomy and Techniques of Cytoreduction

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