Bilateral ovarian metastasis of a Klatskin tumor: A rare case

Abstract

Metastatic carcinomas of the ovary have an important place in all ovarian cancers and tumors. They can originate from many organs and systems and may metastasize to the ovary. The most common primary origin of metastasis is the gastrointestinal tract and then breast tissue. Cholangiocellular carcinomas involving the junction of the right and left bile ducts are called Klatskin tumors, and their metastases to the ovaries are very rare. A woman aged 54 years who had been treated previously for Klatskin tumor was admitted to our clinic due to bilateral ovarian masses and high serum calcium 19-9 levels. The preoperative approach, operative, and postoperative management of Klatskin tumor is presented.

Pancreaticobiliary metastasis presenting as primary mucinous ovarian neoplasm: A systematic literature review

“…The reported diagnosis from the cases extracted from the 39 articles reviewed included 394 primary mucinous ovarian carcinomas (Seidman et al, 2003; Goldstein et al, 2001; Ji et al, 2002; Khunamornpong et al, 2006; Lee and Young, 2003; McCluggage and Young, 2008; Okamoto et al, 2011; Vang et al, 2006a; Vang et al, 2006b; Wang and El-Bahrawy, 2014; Yemelyanova et al, 2008), 171 primary pancreatic carcinoma (Seidman et al, 2003; Petru et al, 1992; Alvarado-Cabrero et al, 2013; Di Marco et al, 2012; Goldstein et al, 2001; Ji et al, 2002; Meriden et al, 2011; Okamoto et al, 2011; Testa et al, 2007; Vang et al, 2006a; Wang and El-Bahrawy, 2014; Young and Hart, 1989; Kim et al, 1999), 108 primary biliary tract carcinoma (Petru et al, 1992; Corr et al, 2013; Garcia et al, 2004; Jain et al, 2006; Jarvi et al, 2006; Khangura et al, 2013; Khunamornpong et al, 2008; Khunamornpong et al, 2007; Khunamornpong et al, 2006; Kumar et al, 2010; Kurt et al, 2016; Lashgari et al, 1992; Lee et al, 2015; Lyra et al, 2015; Meriden et al, 2011; Okamoto et al, 2011; Sun et al, 2012; Taranto et al, 2006; Testa et al, 2007; Vang et al, 2006a; Wang and El-Bahrawy, 2014; Young and Scully, 1990; Park and Kim, 2018; Sharma et al, 1997; Low et al, 2003; Majumdar, and D S, S K, A R, R G, 2007), and 48 unspecified pancreaticobiliary carcinoma (Guerriero et al, 2012; Meriden et al, 2011; Vang et al, 2006b; Yemelyanova et al, 2008; Park and Kim, 2018). All tumors were classified as mucinous.…”

“…There are several case reports in the literature of mucinous ovarian neoplasms metastatic from the pancreaticobiliary tract that presented clinically as primary ovarian neoplasms (Seidman et al, 2003; Petru et al, 1992; Alvarado-Cabrero et al, 2013; Corr et al, 2013; Di Marco et al, 2012; Garcia et al, 2004; Goldstein et al, 2001; Guerriero et al, 2012; Hibner and Greenspan, 2004; Jain et al, 2006; Jarvi et al, 2006; Ji et al, 2002; Khangura et al, 2013; Khunamornpong et al, 2008; Khunamornpong et al, 2007; Khunamornpong et al, 2006; Kim et al, 1999; Kiyokawa et al, 2006; Kumar et al, 2010; Kurt et al, 2016; Lashgari et al, 1992; Lee and Young, 2003; Lee et al, 2015; Lyra et al, 2015; McCluggage and Young, 2008; Meriden et al, 2011; Okamoto et al, 2011; Sun et al, 2012; Taranto et al, 2006; Testa et al, 2007; Vang et al, 2006a; Vang et al, 2006b; Wang and El-Bahrawy, 2014; Yemelyanova et al, 2008; Young and Hart, 1989; Young and Scully, 1990; Park and Kim, 2018). Many of these patients did not present with the typical symptoms of jaundice and back pain, but instead with vague symptoms often associated with ovarian malignancy (abdominal pain, abdominal-pelvic mass).…”

Microinvasive breast cancer with supraclavicular lymph node and ovarian metastasis as clinical findings: a rare case report

“…Tumors metastasizing to the ovary from non-genital organs are associated with poor prognosis. Five-year survival rate for primary ovarian cancer is 40%, whereas in case of metastasis from non-genital organs the rate becomes 12%-24%, and the mean survival is 15 months [11,12] . Survival depends on the prognosis of the primary tumor and when the tumor presents findings with metastases before itself, the prognosis is poorer [12] .…”

“…Five-year survival rate for primary ovarian cancer is 40%, whereas in case of metastasis from non-genital organs the rate becomes 12%-24%, and the mean survival is 15 months [11,12] . Survival depends on the prognosis of the primary tumor and when the tumor presents findings with metastases before itself, the prognosis is poorer [12] . Debulking surgery has a role in patients with metastatic ovarian tumors that originate from nongenital organs, however it is not established that which patients are going to benefit from this technique of surgery [12,13] .…”

“…Survival depends on the prognosis of the primary tumor and when the tumor presents findings with metastases before itself, the prognosis is poorer [12] . Debulking surgery has a role in patients with metastatic ovarian tumors that originate from nongenital organs, however it is not established that which patients are going to benefit from this technique of surgery [12,13] . Yet we consider it worthwhile, because it reduces the required amount of time for final diagnosis and the tumor burden prior to chemotherapy.…”