Surgical Treatment of Cancer of the Cervix Recurring after Primary Irradiation Therapy

Friedell, Gilbert H.; Cesare, Frank; Parsons, Langdon

doi:10.1056/nejm196104202641601

Cited by 15 publications

(9 citation statements)

References 7 publications

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“…One of the major clinical issues associated with RH-AR is the high incidence of treatment-related morbidity. [10][11][12][13][14] Previous studies have reported severe postoperative adverse events occurring in 27%-64% of patients, along with postoperative deaths (Table S1). The most common severe adverse events include urinary tract injury (20%-26%), fistula formation (17%-28%), and ureteral stenosis.…”

Section: Discussionmentioning

confidence: 98%

Radical hysterectomy after radiotherapy for recurrent or persistent cervical cancer

Mabuchi

Kozasa

Kimura

2017

Intl J Gynecology & Obste

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Section: Discussionmentioning

confidence: 98%

Radical hysterectomy after radiotherapy for recurrent or persistent cervical cancer

Mabuchi

Kozasa

Kimura

2017

Intl J Gynecology & Obste

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“…The use of more conservative procedures such as radical hysterectomy with partial resection of bladder and/or rectum has been considered in occasional cases in this setting, but there are no generally accepted guidelines for patient selection. In contrast to the numerous reports in the literature detailing the results of exenterative surgery, only a limited number of papers have appeared addressing the use of radical hysterectomy for recurrent cancer of the cervix (3–11) . Most of these reports include a small number of patients collected over a long period of time, patients who did not receive complete radiotherapy (6,11) and patients who had combined radiation and surgery as their scheduled primary treatment (5,7) .…”

mentioning

confidence: 99%

Radical hysterectomy for recurrent or persistent cervical cancer following radiation therapy

Maneo¹,

Landoni²,

Cormio³

et al. 1999

Int J Gynecol Cancer

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The objective of this paper was to determine the role of radical hysterectomy in persistent or recurrent cervical cancer after primary radiation therapy. Between 1982 and 1995, 34 patients underwent radical hysterectomy for persistent (n = 15) or recurrent (n = 19) cervical cancer after primary radiotherapy. Univariate analysis using log-rank comparison of survival curves was conducted to identify clinical and pathologic factors predictive of survival. The median tumor size at the time of recurrence or persistence was 3.2 cm (range 1-6 cm). 24 patients (70%) had recurrence limited to the uterine cervix; four (12%) had vaginal involvement and six (18%) had early parametrial involvement. No treatment-related deaths were observed. Eighteen major complications (grade III-IV) occurred in 15 cases (44%); 5 patients experienced a fistula. Mean follow-up time was 81 months (range 33-192 months). Recurrent disease was documented in 20 patients (59%), and median time to recurrence was 37 months (range 4-56 months). Fifteen patients (44%) are alive without evidence of disease at a median survival of 81 months (range 33-192), and 18 patients (53%) died of disease with a median survival of 22 months (range 7-106). One patient died of intercurrent disease. Actuarial 5-year survival rate for the whole group is 49%. Patients with FIGO stage IB-IIA at primary diagnosis, no clinical parametrial involvement, and small (

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“…Several authors have reposted the use of radical hysterectomy to treat patients with recurrent or persistent uterine cancer following definitive radiotherapy/ chemoradiation. [17][18][19] With the current advances in radiotherapy delivery techniques, the recurrences rates have reduced and such procedures have become a rarity. Patients up to 2 cm lesion, confined to the cervix with no evidence of hydroureteronephrosis, are candidates for the procedure.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of a case of recurrent carcinoma cervix: a case report

Kalpana

Balamurugan²,

Panda

2020

Int J Reprod Contracept Obstet Gynecol

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Worldwide cervical cancer is the fourth most common cancers among females. Pelvic recurrence, distant metastases, or a combination of both can occur in patients of carcinoma cervix. A 42-year-old P2L2 with a history of carcinoma cervix stage 3-b came to our OPD for routine follow up. Two year back she was managed with chemoradiation for her primary carcinoma which had parametrium extension. There was a 1 × 1 cm lesion on the anterior vaginal wall which was diagnosed to be cervical recurrence. Patient underwent total abdominal hysterectomy with bilateral salpingooophorectomy with pelvic lymphadenectomy. Patient is disease free till now. Treatment decisions should be individualised based on the performance status of the patient, the site of recurrence and/or metastases, the extent of metastatic disease, and prior treatment.

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Surgical Treatment of Cancer of the Cervix Recurring after Primary Irradiation Therapy

Cited by 15 publications

References 7 publications

Radical hysterectomy after radiotherapy for recurrent or persistent cervical cancer

Radical hysterectomy after radiotherapy for recurrent or persistent cervical cancer

Radical hysterectomy for recurrent or persistent cervical cancer following radiation therapy

Surgical management of a case of recurrent carcinoma cervix: a case report

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