Radical hysterectomy after radiotherapy for recurrent or persistent cervical cancer

Abstract

RH-AR was a safe, curative treatment for patients with recurrent or persistent cervical cancer. However, considering the significant risk of surgical adverse events, RH-AR should only be performed for a select group of patients.

Survival benefits with the addition of adjuvant hysterectomy to radiochemotherapy for treatment of stage I‐II adenocarcinoma of the uterine cervix

“…In comparison, in our study, 63.8% of patients received a combination of external beam radiation plus additional brachytherapy. In a study by Mabuchi et al, 8 of 30 (27%) patients who received radical hysterectomy after pelvic external beam irradiation with brachytherapy experienced severe postoperative adverse events, such as ureteral stenosis, ureteral perforation, infected lymphocele, and fistula formation . Kaidar‐Person et al did not report any treatment complications in their series.…”

“…13,26,27 In comparison, in our study, 63.8% of patients received a combination of external beam radiation plus additional brachytherapy. In a study by Mabuchi et al, 28 18 reported that cumulative incidence of severe late morbidity at 2 and 5 years after treatment was higher in patients receiving additional radical hysterectomy than in patients not receiving surgery (16.2% vs 4.3% at 2 years and 22.5% vs 6.5% at 5 years). However, they also noted that severe morbidity was lower in patients who had laparoscopic surgery than in patients who underwent laparotomy (6.7% vs 20.5%).…”

Pharmacological Treatment of Patients with Metastatic, Recurrent or Persistent Cervical Cancer Not Amenable by Surgery or Radiotherapy: State of Art and Perspectives of Clinical Research

“…Radiotherapy or CCRT is the standard treatment for central or lateral pelvic recurrence in patients primarily treated with radical hysterectomy without adjuvant radiotherapy [ 16 , 17 , 18 , 19 , 20 ]. Radical hysterectomy has been seldom used in patients with small (<2 cm) persistent tumor or centrally located recurrence in the cervix or vaginal fornices after definitive radiotherapy [ 16 , 21 , 22 , 23 , 24 ]. This surgical approach obtained 5-year survival rates ranging from 49% to 84%, witha high rate of severe postoperative complications and especially of fistulas.…”

Dislocation Engineered PtPdMo Alloy With Enhanced Antioxidant Activity for Intestinal Injury

“…Radiotherapy is employed in treating many advanced gynecological cancers (Yoshida et al, 2016; Mabuchi et al, 2017). Ionizing radiation is delivered around the target site to destroy and prevent recurrence of malignancy (Song et al, 2017).…”