Dislocation Engineered PtPdMo Alloy With Enhanced Antioxidant Activity for Intestinal Injury

Abstract

Radiotherapy is the mainstay for abdomen and pelvis cancers treatment. However, high energy ray would inflict gastrointestinal (GI) system and adversely disrupt the treatment. The anti-oxidative agents provide a potential route for protecting body from radiation-induced injuries. Herein, highly catalytic nanocubes with dislocation structure are developed for treatment of intestinal injury. Structural and catalytic properties show that Mo incorporation can enhance antioxidant activity by dislocation structure in the alloy. In vitro studies showed that PtPdMo improved cell survival by scavenging radiation-induced ROS accumulation. Furthermore, after animals were exposed to lethal dose of radiation, the survival was increased by 50% with the PtPdMo i.p. treatment. Radioprotection mechanism revealed that PtPdMo alleviated the oxidative stress in multi-organs especially the small intestine by inhibiting intestinal epithelium apoptosis, reducing DNA strands breaks and enhancing repairing ability. In addition, PtPdMo protected hematopoietic system by improving the number of bone marrow and peripheral blood cells.

Development of nanotechnology-mediated precision radiotherapy for anti-metastasis and radioprotection

“…609 Besides, Long et al further introduced Mo into the PtPd nanocubes to improve their ROS scavenging ability. 610 The prepared ternary alloy PtPdMo nanocubes could effectively protect healthy cells from γ-ray irradiation and improve the survival rate of irradiated mice by 50%, which was higher than those pre-treated with Pt (30%) and PtPd (40%) counterparts. In addition, Wang et al incorporated rhodium (Rh) into PtPd nanocubes to prepare ternary PtPdRh nanocubes for investigation of their free radical scavenging capability (Fig.…”

Rational Design of Nanomaterials for Various Radiation‐Induced Diseases Prevention and Treatment

“…In a previous review, we introduced many nanoradioprotectors. Thereafter, new nanoradioprotectors, such as ultrasmall Au‐MoS 2 clusters, [ 177 ] PVP‐coated PtPdMo nanocubes, [ 178 ] PtPd nanocrystals, [ 179 ] naturally derived PHA‐L protein NPs, [ 180 ] CeO 2 /Mn 3 O 4 nanocrystals, [ 57 ] pH‐triggered Mn clusters, [ 181 ] polydopamine@arginine–chitosan (thalidomide) nanodrugs, [ 58 ] Nb 2 C‐PVP nanosheets, [ 31 ] CNSI, [ 32 ] and the GLSO@P188/PEG400 nanosystem, [ 37 ] have emerged. Their emergence enriched the treatment pattern in the radioprotection field.…”

Catalytic Nanozyme for Radiation Protection

“…Recently, PtPdMo nanocubes with multienzyme activities were synthesized by dislocation engineering. 92 The results showed that PtPdMo nanocubes reduced the excess ROS to H 2 O, as well as repairing organ damage by inhibiting intestinal epithelial apoptosis and reducing DNA strand breaks. Meanwhile, Wang et al designed PtPdRh hollow nanocubes (HNCs) not only to exhibit the effects of POD-and CAT-like activities, but also possess the effect of scavenging •OH (Figure 3).…”

“…The 30 day survival rate exhibited that PtPd nanocubes prolonged the survival time of mice, and the survival rate of mice after 7.2 Gy irradiation increased from 0% to 30%. Recently, PtPdMo nanocubes with multienzyme activities were synthesized by dislocation engineering . The results showed that PtPdMo nanocubes reduced the excess ROS to H 2 O, as well as repairing organ damage by inhibiting intestinal epithelial apoptosis and reducing DNA strand breaks.…”