Surgical management of spinal liposarcoma: a case series of 7 patients and literature review

Zhao, Chen; Han, Zhitao; Xiao, Hu; Yang, Cheng; Zhao, Yongfei; Fan, Tianqi; Sun, Zhengwang; Liu, Tielong; Xiao, Jianru

doi:10.1007/s00586-015-4374-3

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…Surgery remains the treatment of choice (Ferrari et al, 2013;Shindle et al, 2002;Zhao et al, 2016) and the surgical quality was often the most significant prognostic factor (Orbach et al, 2010). It is important to emphasize that, for the subtype of FMTs such as desmoid-type fibromatoses, high relapse rates are still observed regardless of surgical resection with histologically free margins (Gronchi et al, 2003;Smith et al, 2000).…”

Section: Notesmentioning

confidence: 99%

Clinical features and prognostic factors of spinal fibroblastic/myofibroblastic tumors: a long-term, single-center, retrospective study

Sun

Zhao

et al. 2020

PeerJ

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Background Spinal fibroblastic and myofibroblastic tumors (FMTs) are extremely rare. Few studies have reported on the features and outcomes of this condition that affects the axial skeleton. We explored the clinical characteristics and factors affecting the prognosis of spinal FMTs. Methods We retroactively assessed the survival of 51 patients with spinal FMTs who underwent surgical and adjuvant treatments in our center between April 2006 and September 2018. Factors affecting disease-free survival (DFS) and overall survival (OS) were analyzed using the Kaplan–Meier method. Variables with p value ≤ 0.05 were subjected to multivariate analysis using the Cox proportional hazards regression model. A two-sided P value < 0.05 was considered statistically significant. Results The mean follow-up period was 50.8 ± 35.6 months (Range 4.2–172.6). Kaplan–Meier survival curves showed that the 5-year DFS was 10% (95% CI [31.09-42.56]) and the 5-year OS was 53% (95% CI [61.28–97.20]). Multivariate analysis showed that en bloc excision was associated with better DFS (HR 0.214, 0.011) and OS (HR 0.273, 0.043), radiotherapy negatively affected OS (HR 0.353, 0.033), and the recurrence and Ki-67 index <5% significantly affected DFS (HR 3.008, 0.008 and 2.754, 0.029). Conclusions Spinal FMTs are rare. Surgery is the treatment of choice and en bloc excision is strongly recommended to improve outcomes. Disease recurrence and the Ki-67 marker are correlated with the progression of these tumors.

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Section: Notesmentioning

confidence: 99%

Clinical features and prognostic factors of spinal fibroblastic/myofibroblastic tumors: a long-term, single-center, retrospective study

Sun

Zhao

et al. 2020

PeerJ

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“…Gender Site Type of tumor Hamlat et al [1] 45 Female Thoracic Pleomorphic Lmejjati et al [5] 45 Male Lumbar Pleomorphic Halevi et al [8] 70 Male Thoracic Pleomorphic de Moraes et al [4] 60 Female Lumbar Pleomorphic Morales-Codina et al [9] 60 Male Lumbar Pleomorphic Cho et al [2] 41 Female Cervical Myxoid Borghei Razavi et al [6] 56 Female Cervical Myxoid Kaneuchi et al [10] 22 Female Thoracic Myxoid Turanli et al [7] 65 Female Lumbar Myxoid Zhao et al [3] 44 Male Lumbar Myxoid Zhao et al [3] 37 Male Lumbar Myxoid Zhao et al [3] 32 Male Cervical Myxoid Present case 79 Male Thoracic Myxoid…”

Section: Conflicts Of Interestmentioning

confidence: 99%

“…Myxoid liposarcoma is the second most common histological type, occurring more frequently between 40 and 60 years of age. [1][2][3] Primary or secondary spinal involvement is very rare, and only sporadic case reports have been published. [1,[4][5][6][7] The aim of this study is to present an extremely rare case of primary myxoid liposarcoma of the thoracic spine in an elderly patient.…”

Section: Introductionmentioning

confidence: 99%

Primary Myxoid Liposarcoma of the Upper Thoracic Spine in an Elderly Patient

Rovlias

Balanika

Nomikos

et al. 2017

Journal of Neurosciences in Rural Practice

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Liposarcoma, one of the most common soft-tissue sarcomas, originates from primitive mesenchymal cells, and its diagnostic criteria have been well established. Myxoid liposarcoma is the second most common histological subtype, occurring more frequently during the fourth and fifth decades of life. There are only a few sporadic published cases of spinal liposarcomas, whatever primary or metastatic. We describe an unusual case of primary myxoid liposarcoma of the thoracic spine in a 79-year-old male, presented with a 2-month history of intractable dorsal pain and progressive weakness of lower limbs. Surgical treatment was performed with wide tumor resection, spinal cord decompression, and posterior instrumentation complemented by radiotherapy. Only one other case has been reported with this spinal localization in the literature. Despite its rarity, myxoid liposarcoma should be considered in the differential diagnosis of primary tumors of the thoracic spine.

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“…In addition, with significantly different from lipoma in the subcutaneous fat layer, liposarcoma often occurs in the deep soft tissue, limbs and retroperitoneum. It mainly affects the middle-aged and elderly people and slightly more common in males than females ( 2 , 3 ). Paratesticular liposarcoma (PLS) is a distinct kind of urinary liposarcoma, which is very rarely observed in the clinic.…”

Section: Introductionmentioning

confidence: 99%

Recurrent paratesticular giant liposarcoma: A case report and literature review

Hua

Zhao

et al. 2023

Front. Surg.

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BackgroundPrimary paratesticular liposarcoma is rarely diagnosed among urinary tumors. In this study, through the retrospective analysis of clinical data and literature review, a case of recurrent paratesticular liposarcoma with lymph node metastasis after radical resection has been reported to explore novel strategies for the diagnosis, treatment and prognosis of this rare disease.Case summaryThe present case involved a patient who was misdiagnosed as a left inguinal hernia for the first time two years ago, but was later diagnosed as mixed liposarcoma by using postoperative pathology. Currently, he is readmitted to the hospital with a recurrence of the left scrotal mass for more than 1 year. Combined with the patient's past medical history, we performed radical resection of the left inguinal and scrotal tumors and lymphadenectomy of left femoral vein. The postoperative pathology indicated that well-differentiated liposarcoma was accompanied by mucinous liposarcoma (about 20%), and lymph node metastasis of left femoral vein both of which occurred at the same time. After the operation, we recommended the patient to receive further radiation therapy, but the patient and his family refused, hence we followed up the patient closely for a long time. During the recent follow-up, the patient reported no complaints of discomfort, and no recurrence of mass in the left scrotum and groin area.ConclusionAfter conducting extensive review of literature, we conclude that radical resection remains the key to treat primary paratesticular liposarcoma, while the significance of the lymph node metastasis is still unclear. The potential effects of postoperative adjuvant therapy depends on the pathological type, and hence close follow-up observation is essential.

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Surgical management of spinal liposarcoma: a case series of 7 patients and literature review

Cited by 10 publications

References 24 publications

Clinical features and prognostic factors of spinal fibroblastic/myofibroblastic tumors: a long-term, single-center, retrospective study

Clinical features and prognostic factors of spinal fibroblastic/myofibroblastic tumors: a long-term, single-center, retrospective study

Primary Myxoid Liposarcoma of the Upper Thoracic Spine in an Elderly Patient

Recurrent paratesticular giant liposarcoma: A case report and literature review

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