Surfactant effects on the in vitro percutaneous absorption of diclofenac sodium

Abstract

Nonionic surfactants, which are a safe class of enhancers, may offer means of enhancing drug permeation through the skin. In order to determine this effect, the influence of four nonionic surfactants on the percutaneous absorption of diclofenac sodium from carbopol gels containing 40% propylene glycol was investigated. In vitro diffusion experiments were carried out using excised full-thickness abdominal rat skin as well as cellulose nitrate membranes. The data of this study clearly revealed that Tween 80 decreased diclofenac penetration rate. This was due to a decrease in thermodynamic activity as a result of micellar complexation. In contrast, the more hydrophobic sorbitans enhanced diclofenac skin penetration, probably due to changes in the barrier properties of the skin and in the vehicle-stratum corneum partition coefficient. The most enhancing effect was induced by Span 20, a surfactant with a C12 saturated hydrophobic group. However, diffusional lag times for all the tested surfactants were longer than for the control gel.

Penetration Enhancing Effect of Polysorbate 20 and 80 on the <i>In Vitro</i> Percutaneous Absorption of LAscorbic Acid

“…In another work, POE-80 was reported to improve the skin permeation of hydrocortisone and lidocaine [23]. It has also been shown that POE-20 accelerated the percutaneous absorption of 5-flourouracil and captopril, and particularly increased the transdermal flux of captopril [19][20][21][22][23]. These findings are largely in agreement with the results obtained in the present work.…”

Effect of surfactant on lycopene-loaded nanostructured lipid carriers

“…Moreover, as we emphasized developing the lycopene-loaded NLC for transdermal application, the surfactants of non-ionic groups particularly with a basic chemical structure of a sugar ester group were used in this study because they were claimed to be skin friendly. Besides their good compatibility with the skin, these surfactants also showed a drug enhancement effect in percutaneous absorption (22,23).…”

Therapeutic effect of topical application of curcumin during treatment of radiation burns in a mini-pig model

“…The topical route of application holds great promise as an effective and safe method of administering curcumin to treat skin injuries [26]. Because most inflammatory diseases develop locally and near the surface of the body, topical application of curcumin to the site of inflammation offers the advantage of delivering the drug directly to the site of disease and thereby producing local effects [23]. However, the barrier properties of intact skin limit the permeability of a wide variety of substances including pharmaceutically active agents [30].…”