Surfactant-based drug delivery systems for treating drug-resistant lung cancer

Abstract

Among all cancers, lung cancer is the major cause of deaths. Lung cancer can be categorized into two classes for prognostic and treatment purposes: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Both categories of cancer are resistant to certain drugs. Various mechanisms behind drug resistance are over-expression of superficial membrane proteins [glycoprotein (P-gp)], lung resistance-associated proteins, aberration of the intracellular enzyme system, enhancement of the cell repair system and deregulation of cell apoptosis. Structure-performance relationships and chemical compatibility are consequently major fundamentals in surfactant-based formulations, with the intention that a great deal investigation is committed to this region. With the purpose to understand the potential of P-gp in transportation of anti-tumor drugs to cancer cells with much effectiveness and specificity, several surfactant-based delivery systems have been developed which may include microspheres, nanosized drug carriers (nanoparticles, nanoemulsions, stealth liposomes, nanogels, polymer-drug conjugates), novel powders, hydrogels and mixed micellar systems intended for systemic and/or localized delivery.

Archaeosomes: an excellent carrier for drug and cell delivery

“…At room temperature 40 C and high pressure (2000 psi) MLVs are extruded through small orifice, which are then collected in suitable container. Uni-or-oligo lamellar archaeosome can obtain using this method (Kaur et al, 2014f). For example, UL vesicles were generated from ML vesicles by extrusion 10 times using a lipid extruder (Lipex, Vancouver, Canada) at the desired temperature (65 C for archaeosomes) through two stacked polycarbonate membranes (pore size ¼ 200 nm) under nitrogen gas pressure (Brown et al, 2009).…”

TPGS‐Functionalized Polydopamine‐Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance

“…[2,29] However, both categories of lung cancer (small cell lung cancer and nonsmall cell lung cancer) are resistant to certain drugs, which is one of the greatest challenges to successful lung cancer chemotherapy. [30,31] To address this challenging threat, d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) was introduced into our drug delivery system. TPGS, formed by esterification reaction of PEG 1000 and vitamin E succinate, could suppress P-glycoprotein (P-gp) meditated MDR in cancer cells by inhibiting P-gp activity.…”

Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development andin vitrocharacterization

“…Nanofibers, due to their unique properties, offer a number of functional features to control the floating behavior of the carrier system (Joshi et al 2014). The properties of nanofibers which are particularly useful in determining the floating behavior are the surface to volume ratio (Kalia et al 2014), specific density (Kataria et al 2014), adsorption characteristics (Kaur et al 2014a), fiber diameter (Kaur et al 2014b), porosity (Kaur et al 2014c), surface hydrophilicity (Kaur et al 2014d), etc. For the past few years, there has been an increasing trend in the development and fabrication of ultrafine polymer fibers for biomedical (Kaur et al 2014e) and biotechnological applications (Kaur et al 2014f ). In the last 10 years, electrospinning has been gaining widespread interest for applications in tissue engineering (Kaur et al 2014g) and drug delivery (Kaur et al 2014h).…”