Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development and<i>in vitro</i>characterization

Malik, Raffi; Garg, Tarun; Goyal, Amit K.; Rath, Goutam

doi:10.3109/21691401.2014.1000492

Cited by 17 publications

(20 citation statements)

References 52 publications

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“…Total floating time, ie, the time period for which the formulation remained buoyant, was measured. 17 In vitro drug release DCNF aerogels were evaluated for in vitro drug release by using a dialysis membrane. HCl buffer (pH 1.2) was used …”

Section: Floating Timementioning

confidence: 99%

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Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

155

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Cellulose nanofiber (CNF) aerogels with favorable floatability and mucoadhesive properties prepared by the freeze-drying method have been introduced as new possible carriers for oral controlled drug delivery system. Bendamustine hydrochloride is considered as the model drug. Drug loading was carried out by the physical adsorption method, and optimization of drug-loaded formulation was done using central composite design. A very lightweight-aerogel-with-matrix system was produced with drug loading of 18.98%±1.57%. The produced aerogel was characterized for morphology, tensile strength, swelling tendency in media with different pH values, floating behavior, mucoadhesive detachment force and drug release profiles under different pH conditions. The results showed that the type of matrix was porous and woven with excellent mechanical properties. The drug release was assessed by dialysis, which was fitted with suitable mathematical models. Approximately 69.205%±2.5% of the drug was released in 24 hours in medium of pH 1.2, whereas ~78%±2.28% of drug was released in medium of pH 7.4, with floating behavior for ~7.5 hours. The results of in vivo study showed a 3.25-fold increase in bioavailability. Thus, we concluded that CNF aerogels offer a great possibility for a gastroretentive drug delivery system with improved bioavailability.

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Section: Floating Timementioning

confidence: 99%

“…Increased surface area of the nanofibers contributes to the significant reduction of bulk density. 17 …”

Section: Floating Timementioning

confidence: 99%

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Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Bhandari¹,

Mishra²,

Mishra³

et al. 2017

IJN

155

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“…The advantages of nanotechnology-based system are shown in Figure 3. They can also be designed for modified drug release from different carriers systems (Malik et al, 2015). Nanotechnology-based drug-delivery systems are broadly classified into four groups including the solid-lipid particulate Hepatitis, burning sensation in extremities, drug interaction, fatigue, fever etc.…”

Section: Nanotechnology-based Drug-delivery Systems In Tuberculosismentioning

confidence: 99%

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

et al. 2015

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From the early sixteenth and seventeenth centuries to the present day of life, tuberculosis (TB) still is a global health threat with some new emergence of resistance. This type of emergence poses a vital challenge to control TB cases across the world. Mortality and morbidity rates are high due to this new face of TB. The newer nanotechnology-based drug-delivery approaches involving micro-metric and nano-metric carriers are much needed at this stage. These delivery systems would provide more advantages over conventional systems of treatment by producing enhanced therapeutic efficacy, uniform distribution of drug molecule to the target site, sustained and controlled release of drug molecules and lesser side effects. The main aim to develop these novel drug-delivery systems is to improve the patient compliance and reduce therapy time. This article reviews and elaborates the new concepts and drug-delivery approaches for the treatment of TB involving solid-lipid particulate drug-delivery systems (solid-lipid micro- and nanoparticles, nanostructured lipid carriers), vesicular drug-delivery systems (liposomes, niosomes and liposphere), emulsion-based drug-delivery systems (micro and nanoemulsion) and some other novel drug-delivery systems for the effective treatment of tuberculosis and role of immunomodulators as an adjuvant therapy for management of MDR-TB and XDR-TB.

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“…It is claimed that nanofibers increase the bioavailability of the drug in the gastroenteric site. Hence, nanofibers provide a stomach-specific drug release for a longer time and increase the local action due to prolonged contact time with the gastric mucosa 63,89…”

Section: Drug Deliverymentioning

confidence: 99%

<p>Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters’ roles</p>

Pérez-González¹,

Villarreal-Gómez²,

Serrano-Medina

et al. 2019

IJN

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Electrospun nanofibers have been widely studied for many medical applications. They can be designed with specific features, including mucoadhesive properties. This review summarizes the polymeric scaffolds obtained by the electrospinning process that has been applied for drug release in different mucosal sites such as oral, ocular, gastroenteric, vaginal, and nasal. We analyzed the electrospinning parameters that have to be optimized to create reproducible and efficient mucoadhesive nanofibers, among them are: electrical field, polymer concentration, viscosity, flow rate, needle-collector distance, solution conductivity, solvent, environmental parameters, and electrospinning setup. We also revised the mucoadhesive theories as well as the mucoadhesive properties of the polymers used. This review shows that the most studied mucosal site is the oral cavity, because it is accessible and easy to evaluate, while the rest are uncomfortable for the patient and difficult to assess in vivo. We found problems that need to be solved for mucoadhesive electrospun nanofibers, such as improving adhesion strength and mucosal permanence time, and the design of unidirectional release, multilayer systems for the treatment of several pathologies, to ensure the drug concentration in the tissue or target organ.

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Diacerein-Loaded novel gastroretentive nanofiber system using PLLA: Development andin vitrocharacterization

Cited by 17 publications

References 52 publications

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Cellulose nanofiber aerogel as a promising biomaterial for customized oral drug delivery

Advances in nanotechnology-based carrier systems for targeted delivery of bioactive drug molecules with special emphasis on immunotherapy in drug resistant tuberculosis – a critical review

<p>Mucoadhesive electrospun nanofibers for drug delivery systems: applications of polymers and the parameters’ roles</p>

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