Surface Modification of Polyacrylonitrile-Based Membranes by Chemical Reactions To Generate Phospholipid Moieties

Abstract

A novel approach for the surface modification of poly(acrylonitrile-co-2-hydroxyethyl methacrylate) (PANCHEMA) membranes by introducing phospholipid moieties is presented, which involved the reaction of the hydroxyl groups on the membrane surface with 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) followed by the ring-opening reaction of COP with trimethylamine. The chemical changes of phospholipid-modified acrylonitrile-based copolymers (PMANCP) membranes were characterized by Fourier transfer infrared spectroscopy and X-ray photoelectron spectroscopy. The surface properties of PMANCP membranes were evaluated by pure water contact angle, protein adsorption, and platelet adhesion measurements. Pure water contact angles measured by the sessile drop method on PMANCP membranes were obviously lower than those measured on the PANCHEMA membranes and decreased with the increase of the content of phospholipid moieties on the membrane surface. It was found that the bovine serum albumin adsorption and platelet adhesion were suppressed significantly with the introduction of phospholipid moieties on the membranes surface. These results demonstrated that the described process was an efficient way to improve the surface biocompatibility for the acrylonitrile-based copolymer membrane.

Plasma surface modification of polypropylene microfiltration membranes and fouling by BSA dispersion

“…During the BSA adsorption measurement, samples were immersed in aqueous medium. As was confirmed by Huang [39] that, in the aqueous environment, the relative high level of free water fraction on the membrane surface can effectively suppress protein adsorption. The lower the water contact angle, the higher level of free water fraction on the membrane surface, as a result, BSA adsorption amount on the membrane surface decreases with the decrease of water contact angle.…”

Pendant small functional groups on poly(ϵ-caprolactone) substrate modulate adhesion, proliferation and differentiation of human mesenchymal stem cells

“…Static water contact angles of polymer films were measured following the sessile drop method using a video contact angle determinater (OCA20, DataPhysics, Germany) [34]. Water (20 L) was dropped on the surface of films and the contact angle (the angle between the liquid/solid interface and the liquid/vapor interface) was recorded after 15 s. For each sample, five measurements were performed.…”

Fabrication and characterization of a novel TiO2 nanoparticle self-assembly membrane with improved fouling resistance

“…tion ratio. And Huang et al [37] also reported that, in the aqueous environment, the relatively high level of free water fraction on the membrane surface can effectively suppress protein irreversible adsorption and cake layer is difficult to come into being. In our study, because of the hydrophobic surface of blend membrane, relatively high amount of BSA protein adsorbed irreversibly on the surface and cake layer formed during protein solution permeation.…”