Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition

Abstract

Despite the importance of nanoparticle’s multipods topology in multivalent-interactions enhanced nano-bio interactions, the precise manipulation of multipods surface topological structures is still a great challenge. Herein, the surface-kinetics mediated multi-site nucleation strategy is demonstrated for the fabrication of mesoporous multipods with precisely tunable surface topological structures. Tribulus-like tetra-pods Fe3O4@SiO2@RF&PMOs (RF = resorcinol-formaldehyde resin, PMO = periodic mesoporous organosilica) nanocomposites have successfully been fabricated with a centering core@shell Fe3O4@SiO2@RF nanoparticle, and four surrounding PMO nanocubes as pods. By manipulating the number of nucleation sites through mediating surface kinetics, a series of multipods mesoporous nanocomposites with precisely controllable surface topological structures are formed, including Janus with only one pod, nearly plane distributed dual-pods and tri-pods, three-dimensional tetrahedral structured tetra-pods, etc. The multipods topology endows the mesoporous nanocomposites enhanced bacteria adhesion ability. Particularly, the tribulus-like tetra-pods mesoporous nanoparticles show ~100% bacteria segregation and long-term inhibition over 90% after antibiotic loading.

Clusterization-triggered emission: Uncommon luminescence from common materials

“…At the same time, the use of AIEgens endows the bioimaging experiments with wash-free characteristics on account of the nonluminescent behavior of single-molecule species. AIEgens also have other favorable characteristics such as high photostabilities and large Stokes shifts (the difference between maximum absorption and emission wavelength), which had led to them being widely used in life sciences, optical electronics, and as chemoprobes or bioprobes, etc [29][30][31][32][33][34][35][36] .…”

Treatment of MRSA-infected osteomyelitis using bacterial capturing, magnetically targeted composites with microwave-assisted bacterial killing

“…An active bacteria-targeting nanocapturer with controlled release of antibiotics in particular not only reduces the toxicity of antibiotics but also improves therapeutic effects for bacterial infections 9 . This bacteria-targeting capability can also be achieved by promoting interaction between nanoagents and bacteria via their chemical components on the surface (e.g., proteins, peptidoglycan, and lipopolysaccharides) 25 , 26 . It has been reported that physical forces such as magnetic fields can deliver drug-loaded nanoplatform to infection sites with high specificity and efficiency 27 .…”

Ternary MOF-on-MOF heterostructures with controllable architectural and compositional complexity via multiple selective assembly

“…Hybrid materials especially nanostructures with high complexity have attracted intensive attention due to their elegant structures and elaborate functionalities 1 – 4 . The nanostructural complexity can be classified according to (1) composition (e.g., conjugating different components) 5 , 6 , (2) architecture (e.g., manipulating geometric arrangements) 7 – 9 , and (3) the integration of both compositional and architectural diversity into one nanostructrure 10 – 12 . As an important family of porous crystalline materials, the composition and architecture of metal-organic frameworks (MOFs) are both key factors for their properties and applications 13 – 19 .…”