Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: In vitro characterization

Azemi, Erdrin; Stauffer, William R.; Gostock, Mark S.; Lagenaur, Carl F.; Cui, Xinyan Tracy

doi:10.1016/j.actbio.2008.02.028

Cited by 88 publications

(99 citation statements)

References 44 publications

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“…As the PDMS carrier accounts for the major part of the implant surface, neuronal processes may tend to migrate away from the cochlear implant. The recent work by Cui et al [42,43] sheds a light on the important role of the substrate on the biocompatibility of neural probes. In these studies, neuronal loss and gliotic response within the vicinity of unmodified neural probes implanted into the CNS were significantly reduced by surface immobilisation of neuron specific L1 protein on the substrate of the neural probes [42,43].…”

Section: In Vitro Growth and Differentiation Of Pc12mentioning

confidence: 98%

“…The recent work by Cui et al [42,43] sheds a light on the important role of the substrate on the biocompatibility of neural probes. In these studies, neuronal loss and gliotic response within the vicinity of unmodified neural probes implanted into the CNS were significantly reduced by surface immobilisation of neuron specific L1 protein on the substrate of the neural probes [42,43]. A comprehensive approach, combining both electrode and substrate modification, may lead to a better solution to a stable and long-term implant-neural interface [44].…”

Section: In Vitro Growth and Differentiation Of Pc12mentioning

confidence: 98%

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Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid – Collagen conjugate for neural interfacing

et al. 2011

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Section: In Vitro Growth and Differentiation Of Pc12mentioning

confidence: 98%

Section: In Vitro Growth and Differentiation Of Pc12mentioning

confidence: 98%

Bio-functionalisation of polydimethylsiloxane with hyaluronic acid and hyaluronic acid – Collagen conjugate for neural interfacing

et al. 2011

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“…A more biologically compatible electrode could incorporate bioactive agents to mediate interactions at the interface, including anti-inflammatory agents to attenuate astroglial scarring events, [9][10][11][12] chemo-attractants to encourage neural outgrowth towards the electrode [13][14][15][16] and/or tethered cell adhesion motifs to promote cell anchorage to the electrode surface. 14,17,18 Conducting polymer (CP) electrode coatings are potential components of more sophisticated NPEs. They undergo oxidative and reductive chemical processes accompanied by changes in a range of mechanical and electrical properties.…”

Section: Introductionmentioning

confidence: 99%

Gellan gum doped polypyrrole neural prosthetic electrode coatings

et al. 2011

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Surface modification of neural prosthetic electrodes with polymeric materials, in particular, conducting polymers and hydrogels, has the potential to circumvent many problems associated with currently used electrode platforms. These problems include the disparity in mechanical properties between implanted electrodes and host neural tissue and the lack of biofunctionality at the electrode surface, both of which dissuade favourable reception of the implanted device. We have developed conducting polymer electrode coatings doped with the polysaccharide gellan gum, as a platform for improved functionality of neural prosthetic electrodes. Our electrode coatings, prepared by galvanostatic electropolymerisation, significantly reduced the impedance magnitude at frequencies relevant to neural cells, relative to uncoated gold Mylar electrodes (24 3 U at 1 kHz). Cyclic voltammetry was used to explore the electrochemical stability of the coatings, which lose only 23 2% charge carrying capacity when subjected to 400 redox cycles. The coatings show no change in impedance magnitude at 1 kHz when subject to 32 h of clinically relevant charge balanced current stimulation. Surface modification of neural prosthetic electrodes with polymeric materials, in particular, conducting polymers and hydrogels, has the potential to circumvent many problems associated with currently used electrode platforms. These problems include the disparity in mechanical properties between implanted electrodes and host neural tissue and the lack of biofunctionality at the electrode surface, both of which dissuade favourable reception of the implanted device. We have developed conducting polymer electrode coatings doped with the polysaccharide gellan gum, as a platform for improved functionality of neural prosthetic electrodes. Our electrode coatings, prepared by galvanostatic electropolymerisation, significantly reduced the impedance magnitude at frequencies relevant to neural cells, relative to uncoated gold Mylar electrodes (24 AE 3 U at 1 kHz). Cyclic voltammetry was used to explore the electrochemical stability of the coatings, which lose only 23 AE 2% charge carrying capacity when subjected to 400 redox cycles. The coatings show no change in impedance magnitude at 1 kHz when subject to 32 h of clinically relevant charge balanced current stimulation.

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“…To improve the chronic integration of neural implants in the brain, various biological, biochemical or electroactive coatings have already been evaluated [2][3][4]. These are designed to accommodate the differences in biofunctionality between the man-made electrode implant and the surrounding neuronal cells.…”

Section: Introductionmentioning

confidence: 99%