Surface functionalized bioceramics coated on metallic implants for biomedical and anticorrosion performance – a review

Kaliaraj, Gobi Saravanan; Siva, T.

doi:10.1039/d1tb01301g

Cited by 33 publications

(15 citation statements)

References 174 publications

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“…In contrast to highly crystalline HAp, calcium phosphate-based coatings have high solubility in an aqueous medium that reduces coating stability and can cause implant loosening. Because of its similar properties to the inorganic composition of hard tissue such as bone and teeth [272], HAp (Ca 10 (PO 4 ) 6 (OH) 2 , Ca/P = 1.67) is frequently employed as bioactive material. HAp has shown exceptional biocompatibility, osteo-inductivity, osteoconductive and bioactivity [273].…”

Section: Calcium Phosphates and Hydroxyapatitementioning

confidence: 99%

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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To fix the bone in orthopedics, it is almost always necessary to use implants. Metals provide the needed physical and mechanical properties for load-bearing applications. Although widely used as biomedical materials for the replacement of hard tissue, metallic implants still confront challenges, among which the foremost is their low biocompatibility. Some of them also suffer from excessive wear, low corrosion resistance, infections and shielding stress. To address these issues, various coatings have been applied to enhance their in vitro and in vivo performance. When merged with the beneficial properties of various bio-ceramic or polymer coatings remarkable bioactive, osteogenic, antibacterial, or biodegradable composite implants can be created. In this review, bioactive and high-performance coatings for metallic bone implants are systematically reviewed and their biocompatibility is discussed. Updates in coating materials and formulations for metallic implants, as well as their production routes, have been provided. The ways of improving the bioactive coating performance by incorporating bioactive moieties such as growth factors, osteogenic factors, immunomodulatory factors, antibiotics, or other drugs that are locally released in a controlled manner have also been addressed.

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Section: Calcium Phosphates and Hydroxyapatitementioning

confidence: 99%

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Nikolova

Apostolova

2022

Materials

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“…During the “stress shielding” effect, the mismatch in modulus between the bone and implant interface results in decreased physiologic loading of the bone when the metal implants are fixed at the fractured site [ 11 , 12 ]. In spite of the fact that metallic implants have good mechanical properties and are generally affordable, their insufficient biological activity poses a disadvantage [ 12 , 13 ]. The low corrosion resistance, tendency to infection, lack of proper biological activities, and subsequent weak integration with contacted bone tissue are some of the primary concerns that drive to develop multifunctional and bioactive metallic implants that act as local drug delivery platforms [ 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…In spite of the fact that metallic implants have good mechanical properties and are generally affordable, their insufficient biological activity poses a disadvantage [ 12 , 13 ]. The low corrosion resistance, tendency to infection, lack of proper biological activities, and subsequent weak integration with contacted bone tissue are some of the primary concerns that drive to develop multifunctional and bioactive metallic implants that act as local drug delivery platforms [ 13 , 14 , 15 ]. In order to influence the regeneration process dynamically, they are first supposed to interfere with the response of the host body, then increase the integration with the implant, promote osteoconduction and the angiogenesis on the surface of them, and finally slow down the microbial infection process.…”

Section: Introductionmentioning

confidence: 99%

Recent Advancements in Metallic Drug-Eluting Implants

et al. 2023

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Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

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“…The mechanical, chemical, and physical properties of metal or metal alloy surfaces contribute to the origin of surface oxidation in the presence of oxidants (e.g., salt solutions and ions). Mechanistic understanding of such surface corrosion on metal and mixed-metal alloys is an important factor that provides a synthesis strategy for material design such as electrocatalysts, − medical devices, , and automotive/structural metals . In order to understand surface corrosion kinetics, bulk direct current (DC) and alternating current (AC) electrochemical techniques such as Tafel polarization and electrochemical impedance spectroscopy (EIS) have been widely used .…”

Section: Introductionmentioning

confidence: 99%

Understanding Localized Corrosion on Metal Surfaces Using Scanning Electrochemical Cell Impedance Microscopy (SECCIM)

et al. 2022

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Understanding the electrochemical properties at a localized scale is critically important to comprehend the origin of corrosion and develop multifunctional materials with robust corrosion resistance, particularly at conjoined metal interfaces typically encountered in automobile manufacturing. Scanning electrochemical cell microscopy (SECCM) is an emerging technique which enables to study the corrosion of metal surfaces to be visualized at the microscopic level. In this work, we developed scanning electrochemical cell impedance microscopy (SECCIM) by combining SECCM with electrochemical impedance spectroscopy (EIS) and explored the unique advantages of using SECCIM to measure the corrosion kinetics on single-crystal Mg (0001) as the model surface using direct current and alternating current polarization techniques. Specifically, a theta capillary with a tip diameter of 10 μm filled with a 0.01 M NaCl electrolyte was used as a probe to perform spatially resolved potentiodynamic Tafel polarization and EIS. The combination of traditional SECCM with EIS led to the development of SECCIM and enabled us to study small interfacial events such as charge transfer, adsorption, and emergence of resistive oxide films on the surface using the distribution of relaxation time analysis. Furthermore, by comparing localized SECCIM measurements with bulk electrochemical measurements, we establish the reliability of SECCIM for the mapping of corrosion potential and associated charge-transfer resistance on the Mg (0001) surface. Our results indicate that SECCIM measurement with Tafel and EIS analysis will provide an unparalleled ability to characterize the pitting corrosion mechanism on the heterogeneous surface of mixed-metal alloys and metal joints.

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Surface functionalized bioceramics coated on metallic implants for biomedical and anticorrosion performance – a review

Abstract: In modern days, the usage of trauma fixation devices is significantly increased due to sports injury, age-related issues, accidents and revision surgery purposes. Numerous materials such as stainless steel, titanium,...

Cited by 33 publications

References 174 publications

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Advances in Multifunctional Bioactive Coatings for Metallic Bone Implants

Recent Advancements in Metallic Drug-Eluting Implants

Understanding Localized Corrosion on Metal Surfaces Using Scanning Electrochemical Cell Impedance Microscopy (SECCIM)

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