Recent Advancements in Metallic Drug-Eluting Implants

Abstract

Over the past decade, metallic drug-eluting implants have gained significance in orthopedic and dental applications for controlled drug release, specifically for preventing infection associated with implants. Recent studies showed that metallic implants loaded with drugs were substituted for conventional bare metal implants to achieve sustained and controlled drug release, resulting in a desired local therapeutic concentration. A number of secondary features can be provided by the incorporated active molecules, including the promotion of osteoconduction and angiogenesis, the inhibition of bacterial invasion, and the modulation of host body reaction. This paper reviews recent trends in the development of the metallic drug-eluting implants with various drug delivery systems in the past three years. There are various types of drug-eluting implants that have been developed to meet this purpose, depending on the drug or agents that have been loaded on them. These include anti-inflammatory drugs, antibiotics agents, growth factors, and anti-resorptive drugs.

Engineering 3D-Printed Advanced Healthcare Materials for Periprosthetic Joint Infections

“…For decades, metals have been widely used for developing and manufacturing orthopedic implants, because of their optimal mechanical properties, plasticity, toughness, corrosion and wear resistance, and biocompatibility [ 89 , 90 ]. Moreover, metallic implants can be combined with drug delivery systems, referred to as IDDS combination products (drugs/devices) by the US Food and Drug Administration (FDA) [ 91 ].…”

“…For improving metal properties in parenteral drug delivery, the most common technique is applying coatings to the implant surface, which not only serves as an eluting mechanism for drug delivery but also for increasing biocompatibility, the adhesion of molecules to the surface, osteointegration, and reducing the release of toxic ions [ 89 , 90 ]. For example, metallic implants have been coated with antimicrobials for preventing infections, as microorganisms can grow easily on the surface of these materials [ 91 ].…”

TiO2/PEG as smart anticorrosion and drug-eluting platforms in inflammatory conditions

“…Polymeric coatings have garnered attention for their ability to resist corrosive media and act as local drug delivery systems for anti-inflammatory agents [ 4 , 5 ]. The development of stimuli-responsive and smart drug-eluting implants aligns with the growing popularity of precision medicine and personalized pharmacotherapy [ 6 ].…”

Effect of continuous local dexamethasone on tissue biomechanics and histology after inhalational burn in a preclinical model

“…Drug‐eluting biomaterials have been used in a variety of medical settings to provide controlled release of therapeutics limited to local tissues 10–12 . Importantly, these biomaterials are often combined with other required medical management such as bandages or stents.…”

“…Drug‐eluting biomaterials have been used in a variety of medical settings to provide controlled release of therapeutics limited to local tissues. 10 , 11 , 12 Importantly, these biomaterials are often combined with other required medical management such as bandages or stents. Topical biomaterials are beginning to be examined for laryngeal or airway injury, particularly with using ETTs for drug delivery.…”