Surface-Enhanced Raman Scattering Spectroscopy and Microfluidics: Towards Ultrasensitive Label-Free Sensing

Kant, Kamal; Abalde‐Cela, Sara

doi:10.3390/bios8030062

Cited by 38 publications

(33 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On-chip SERS detection with well-controlled flow conditions yields more reproducible results, and several problems—for example, variable mixing times, variable scattering geometries, localized heating, and photo-dissociation—could be effectively solved. Integrating with microfluidics provides more consistent geometries and heat dissipation properties, which benefits photosensitive or heat-sensitive analytes [ 83 ].…”

Section: Methods Of Integration With Optical Biosensorsmentioning

confidence: 99%

Review of Integrated Optical Biosensors for Point-of-Care Applications

et al. 2020

View full text Add to dashboard Cite

This article reviews optical biosensors and their integration with microfluidic channels. The integrated biosensors have the advantages of higher accuracy and sensitivity because they can simultaneously monitor two or more parameters. They can further incorporate many functionalities such as electrical control and signal readout monolithically in a single semiconductor chip, making them ideal candidates for point-of-care testing. In this article, we discuss the applications by specifically looking into point-of-care testing (POCT) using integrated optical sensors. The requirement and future perspective of integrated optical biosensors for POC is addressed.

show abstract

Section: Methods Of Integration With Optical Biosensorsmentioning

confidence: 99%

Review of Integrated Optical Biosensors for Point-of-Care Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…() applied a millifluidic chip system with multiple functions for extracting (e.g., mixing, filtration, and solid‐phase extraction) benzoyl peroxide in flour products before SERS analysis, resulting in LOD of 0.035 and 0.1 g/kg for flour and steamed bun, respectively. The combination of SERS with microfluidic platforms has become an important area in recent years and there are a number of review papers covering the relevant principles, applications, advantages, pitfalls, and possible solutions (Jahn et al., ; Kant & Abalde‐Cela, ; Liao & Lu, ; Pu, Xiao, & Sun, ).…”

Section: Basic Principles Behind Sersmentioning

confidence: 99%

Trace analysis of organic compounds in foods with surface‐enhanced Raman spectroscopy: Methodology, progress, and challenges

Huang

Wang

Lai

et al. 2020

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

Surface‐enhanced Raman spectroscopy (SERS) provides a potential solution for rapid analysis of trace compounds such as residual pesticides, naturally occurred toxicants, banned or restricted drugs, and food additives in complex food matrices. In this review, the basic principles of SERS and general approaches to successfully apply SERS in food analysis are covered from an applications perspective. The key steps including substrate selection and evaluation, sample preparation and simplification, spectral collection, and data analysis during the development of SERS methods for food analysis are summarized, together with the discussion of typical underlying technical barriers or major challenges of these methods and their applications. Future directions in successfully applying SERS technology as a routine analytical approach to solve real‐world food problems are analyzed. This comprehensive review summarizes the recent progress on theory, application, and scope of SERS for food analysis, providing a basic understanding of the technology; more importantly, key methodology, potential pitfalls, and possible solutions during the development of rapid SERS methods based on authors’ years of SERS experience are shared with researchers in the field.

show abstract

“…Actually, one of the techniques that most benefited from advances in nanotechnology is SERS. This ultrasensitive analytical technique overcomes the intrinsic low efficiency of Raman by using nanoparticles (NPs), which reach up to enhancing factors of 10 12 -10 14 orders of magnitude [1,2]. The high sensitivity of this analytical tool allows it to be used to detect chemical and biological analytes that interact with active SERS substrates, even at very low detection limits [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor

Teixeira

Hernández-Rodríguez

et al. 2019

Applied Sciences

Self Cite

View full text Add to dashboard Cite

Surface-enhanced Raman scattering (SERS) spectroscopy stands out due to its sensitivity, selectivity, and multiplex ability. The development of ready-to-use, simple, and low-cost SERS substrates is one of the main challenges of the field. In this paper, the intrinsic reproducibility of microfluidics technology was used for the fabrication of self-assembled nanoparticle structures over a paper film. The paper SERS substrates were fabricated by assembling anisotropic particles, gold nanostars (GNSs), and nanorods (NRs) onto paper to offer an extra enhancement to reach ultra-sensitive detection limits. A polydimethylsiloxane PDMS-paper hybrid device was used to control the drying kinetics of the nanoparticles over the paper substrate. This method allowed a high reproducibility and homogeneity of the fabrication of SERS substrates that reach limits of detection down to the picomolar range. This simple and low-cost fabrication of a paper-based sensing device was tested for the discrimination of different cell lineages.

show abstract

Surface-Enhanced Raman Scattering Spectroscopy and Microfluidics: Towards Ultrasensitive Label-Free Sensing

Cited by 38 publications

References 88 publications

Review of Integrated Optical Biosensors for Point-of-Care Applications

Review of Integrated Optical Biosensors for Point-of-Care Applications

Trace analysis of organic compounds in foods with surface‐enhanced Raman spectroscopy: Methodology, progress, and challenges

Microfluidics-Driven Fabrication of a Low Cost and Ultrasensitive SERS-Based Paper Biosensor

Contact Info

Product

Resources

About