Review of Integrated Optical Biosensors for Point-of-Care Applications

Chen, Yung-Tsan; Lee, Ya-Chu; Lai, Yao-Hsuan; Lim, Jin-Chun; Huang, Nien-Tsu; Lin, Chih‐Ting; Huang, Jui Hsien

doi:10.3390/bios10120209

Cited by 109 publications

(71 citation statements)

References 125 publications

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“…This need asks for renovated fabrication strategies of point-of-care testing (POCT) devices, which show ease-of-use, compact size, and limited costs [118,119]. Many examples of already commercialized POCT have been reviewed recently and include pregnancy tests, glucose testing, and HIV testing [120]. LSPR-and SERS-based flexible biosensors are promising transducers for the design of a POCT due to the ease of integration with microelectronics and microfluidics [121] (Figure 6a).…”

Section: Promising Applications Of Flexible Biosensors 41 Point-of-care Testing For Disease Diagnosismentioning

confidence: 99%

“…More precisely, microfluidic channels must be highly transparent, to be compatible with light pathways, they should ensure an efficient sample delivery and minimize reagents and sample consumption [119]. On the other side, spectrometers and light sources (optical components) must be miniaturized to obtain a compact device and, although this is often not very easy, some methods to integrate LEDs for the transducer illumination and miniaturized spectrometers for the collection of the signal have been already proposed to overcome this issue [120]. POCTs for the diagnosis of disease especially in developing countries, where expensive laboratory equipment and specialized operators are not easily available are crucial for the rapid screening of a population.…”

Section: Promising Applications Of Flexible Biosensors 41 Point-of-care Testing For Disease Diagnosismentioning

confidence: 99%

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Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications

et al. 2021

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Over the last 30 years, optical biosensors based on nanostructured materials have obtained increasing interest since they allow the screening of a wide variety of biomolecules with high specificity, low limits of detection, and great sensitivity. Among them, flexible optical platforms have the advantage of adapting to non-planar surfaces, suitable for in vivo and real-time monitoring of diseases and assessment of food safety. In this review, we summarize the newest and most advanced platforms coupling optically active materials (noble metal nanoparticles) and flexible substrates giving rise to hybrid nanomaterials and/or nanocomposites, whose performances are comparable to the ones obtained with hard substrates (e.g., glass and semiconductors). We focus on localized surface plasmon resonance (LSPR)-based and surface-enhanced Raman spectroscopy (SERS)-based biosensors. We show that large-scale, cost-effective plasmonic platforms can be realized with the currently available techniques and we emphasize the open issues associated with this topic.

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Section: Promising Applications Of Flexible Biosensors 41 Point-of-care Testing For Disease Diagnosismentioning

confidence: 99%

Section: Promising Applications Of Flexible Biosensors 41 Point-of-care Testing For Disease Diagnosismentioning

confidence: 99%

Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications

et al. 2021

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“…SPR [94], interferometer [95], and microcavity [96] chips, as well as PhC [97,98] and fiber optic-type sensors [99], have all been integrated with microfluidic cells or other systems to create POC devices. The realization of these techniques into integrated, POCtype devices is mostly limited to research lab development, though some techniques have been commercialized [100]. argue that these types of integrated biosensors will act as key players in the future market of miniaturized, POC technology as their sensitivities, accuracy, and fabrication processes improve [100].…”

Section: Affinity-type Biosensors With Optical Signal Amplificationmentioning

confidence: 99%

Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens

et al. 2021

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The COVID-19 pandemic has made it abundantly clear that the state-of-the-art biosensors may not be adequate for providing a tool for rapid mass testing and population screening in response to newly emerging pathogens. The main limitations of the conventional techniques are their dependency on virus-specific receptors and reagents that need to be custom-developed for each recently-emerged pathogen, the time required for this development as well as for sample preparation and detection, the need for biological amplification, which can increase false positive outcomes, and the cost and size of the necessary equipment. Thus, new platform technologies that can be readily modified as soon as new pathogens are detected, sequenced, and characterized are needed to enable rapid deployment and mass distribution of biosensors. This need can be addressed by the development of adaptive, multiplexed, and affordable sensing technologies that can avoid the conventional biological amplification step, make use of the optical and/or electrical signal amplification, and shorten both the preliminary development and the point-of-care testing time frames. We provide a comparative review of the existing and emergent photonic biosensing techniques by matching them to the above criteria and capabilities of preventing the spread of the next global pandemic.

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“…A study showed optical biosensors based on a combined Mach–Zehnder interferometer. The methodology featured applying compatible microfluidics (COMS) to diagnose DNA without labeling [ 27 , 28 , 29 , 30 , 31 ]. Previous studies have reported the detection and classification of specific viruses via quantitative analysis and sorting of viruses and other particles in the micron and nanoparticle size ranges using light scattering and fluorescence measurements.…”

Section: Introductionmentioning

confidence: 99%

Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and Perspectives

et al. 2021

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The propagation of viruses has become a global threat as proven through the coronavirus disease (COVID-19) pandemic. Therefore, the quick detection of viral diseases and infections could be necessary. This study aims to develop a framework for virus diagnoses based on integrating photonics technology with artificial intelligence to enhance healthcare in public areas, marketplaces, hospitals, and airfields due to the distinct spectral signatures from lasers’ effectiveness in the classification and monitoring of viruses. However, providing insights into the technical aspect also helps researchers identify the possibilities and difficulties in this field. The contents of this study were collected from six authoritative databases: Web of Science, IEEE Xplore, Science Direct, Scopus, PubMed Central, and Google Scholar. This review includes an analysis and summary of laser techniques to diagnose COVID-19 such as fluorescence methods, surface-enhanced Raman scattering, surface plasmon resonance, and integration of Raman scattering with SPR techniques. Finally, we select the best strategies that could potentially be the most effective methods of reducing epidemic spreading and improving healthcare in the environment.

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Review of Integrated Optical Biosensors for Point-of-Care Applications

Cited by 109 publications

References 125 publications

Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications

Recent Advances in the Fabrication and Functionalization of Flexible Optical Biosensors: Toward Smart Life-Sciences Applications

Roadmap on Universal Photonic Biosensors for Real-Time Detection of Emerging Pathogens

Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and Perspectives

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