Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and Perspectives

Taha, Bakr Ahmed; Mashhadany, Yousif Al; Bachok, Nur Nadia; Bakar, Ahmad Ashrif A; Mokhtar, Mohd Hadri Hafiz; Zan, Mohd Saiful Dzulkefly; Arsad, Norhana

doi:10.3390/diagnostics11061119

Cited by 41 publications

(14 citation statements)

References 101 publications

(101 reference statements)

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“…The PCR protocol amplifies single-stranded DNA to 100 billion copies after 40 cycles of doubling, to achieve a sufficient fluorescent-signal strength for virus detection, which takes hours. Identification of unique gene sequences and single nucleotide polymorphisms by SERS-amplified signals provides more accurate and cost-effective diagnosis, while DNA amplification from COVID-19 does not require a long time [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Flexible SERS-Based Sensing Platform for Detection of COVID-19

et al. 2022

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COVID-19 continues to spread and has been declared a global emergency. Individuals with current or past infection should be identified as soon as possible to prevent the spread of disease. Surface-enhanced Raman spectroscopy (SERS) is an analytical technique that has the potential to be used to detect viruses at the site of therapy. In this context, SERS is an exciting technique because it provides a fingerprint for any material. It has been used with many COVID-19 virus subtypes, including Deltacron and Omicron, a novel coronavirus. Moreover, flexible SERS substrates, due to their unique advantages of sensitivity and flexibility, have recently attracted growing research interest in real-world applications such as medicine. Reviewing the latest flexible SERS-substrate developments is crucial for the further development of quality detection platforms. This article discusses the ultra-responsive detection methods used by flexible SERS substrate. Multiplex assays that combine ultra-responsive detection methods with their unique biomarkers and/or biomarkers for secondary diseases triggered by the development of infection are critical, according to this study. In addition, we discuss how flexible SERS-substrate-based ultrasensitive detection methods could transform disease diagnosis, control, and surveillance in the future. This study is believed to help researchers design and manufacture flexible SERS substrates with higher performance and lower cost, and ultimately better understand practical applications.

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Section: Introductionmentioning

confidence: 99%

Highly Sensitive Flexible SERS-Based Sensing Platform for Detection of COVID-19

et al. 2022

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“…Photonic techniques involve the use of light for energy generation, detection, and/or the transmission of information; microscopy and optical communications techniques are common examples of photonic techniques. Recent studies have explored the development of biophotonic sensors based on spectroscopic emission and the absorption of laser energy [ 10 ]. Molecular spectroscopic techniques have enabled researchers to better understand the host response and the diagnosis of viral diseases [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Novel photonic methods for diagnosis of SARS‐CoV‐2 infection

Joshi

Shukla

Narayan

2022

Transl Biophotonics

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The COVID-19 pandemic that began in March 2020 continues in many countries. The ongoing pandemic makes early diagnosis a crucial part of efforts to prevent the spread of SARS-CoV-2 infections. As such, the development of a rapid, reliable, and low-cost technique with increased sensitivity for detection of SARS-CoV-2 is an important priority of the scientific community. At present, nucleic acid-based techniques are primarily used as the reference approach for the detection of SARS-CoV-2 infection. However, in several cases, false positive results have been observed with these techniques. Due to the drawbacks associated with existing techniques, the development of new techniques for the diagnosis of COVID-19 is an important research activity. We provide an overview of novel diagnostic methods for SARS-CoV-2 diagnosis that integrate photonic technology with artificial intelligence. Recent developments in emerging diagnostic techniques based on the principles of advanced molecular spectroscopy and microscopy are considered.

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“…Optical methods such as optical sensing, spectroscopy, and imaging established a great potential [19]. At present, various review articles, research, laboratories, and companies dedicated their attention to applying the optical techniques for sensing the COVID-19 virus [8,[19][20][21]. The nearinfrared spectroscopy (NIRS) technology has shown huge advantages and potential as a diagnostic method in offering physical and chemical information [22], and also, details on the molecular compositions and structures of biological components [23].…”

Section: Introductionmentioning

confidence: 99%

Near-Infrared Spectroscopy as a Potential COVID-19 Early Detection Method: A Review and Future Perspective

Raypah

Faris

Azlan

et al. 2022

Sensors

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The coronavirus disease 2019 (COVID-19) pandemic is a worldwide health anxiety. The rapid dispersion of the infection globally results in unparalleled economic, social, and health impacts. The pathogen that causes COVID-19 is known as a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A fast and low-cost diagnosis method for COVID-19 disease can play an important role in controlling its proliferation. Near-infrared spectroscopy (NIRS) is a quick, non-destructive, non-invasive, and inexpensive technique for profiling the chemical and physical structures of a wide range of samples. Furthermore, the NIRS has the advantage of incorporating the internet of things (IoT) application for the effective control and treatment of the disease. In recent years, a significant advancement in instrumentation and spectral analysis methods has resulted in a remarkable impact on the NIRS applications, especially in the medical discipline. To date, NIRS has been applied as a technique for detecting various viruses including zika (ZIKV), chikungunya (CHIKV), influenza, hepatitis C, dengue (DENV), and human immunodeficiency (HIV). This review aims to outline some historical and contemporary applications of NIRS in virology and its merit as a novel diagnostic technique for SARS-CoV-2.

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Detection of COVID-19 Virus on Surfaces Using Photonics: Challenges and Perspectives

Cited by 41 publications

References 101 publications

Highly Sensitive Flexible SERS-Based Sensing Platform for Detection of COVID-19

Highly Sensitive Flexible SERS-Based Sensing Platform for Detection of COVID-19

Novel photonic methods for diagnosis of SARS‐CoV‐2 infection

Near-Infrared Spectroscopy as a Potential COVID-19 Early Detection Method: A Review and Future Perspective

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