Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies

Morra, Marco; Cassinelli, Clara; Cascardo, G.; Cahalan, Patrick T.; Cahalan, Linda; Fini, Milena; Giardino, Roberto

doi:10.1016/s0142-9612(03)00360-0

Cited by 197 publications

(185 citation statements)

References 38 publications

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“…Examples are the adsorption of PEO to silica [847], of poly(sodium styrenesulfonate) (PSS) to silica and alumina [161,442], and modified polyisobutylene with surfactants to steel [848]. In some cases the study of steric interactions is applied to biological and medical issues, like in the case of Morra et al [849] (collagen on titanium surfaces) and of Brown and Hoh [850] (neurofilaments).…”

Section: Steric Forcesmentioning

confidence: 99%

Force measurements with the atomic force microscope: Technique, interpretation and applications

Butt

Cappella

Kappl

2005

Surface Science Reports

3,187

2,949

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Section: Steric Forcesmentioning

confidence: 99%

Force measurements with the atomic force microscope: Technique, interpretation and applications

Butt

Cappella

Kappl

2005

Surface Science Reports

3,187

2,949

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“…Collagen, being the main organic component of the ECM, induces positive effects concerning cellular adhesion, proliferation, and differentiation of many cell types in culture (175)(176)(177). Furthermore, collagen exhibits high in vivo biodegradability and excellent biocompatibility (178).…”

Section: Collagen-cap Composite Coatingsmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

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Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

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“…In the same vein, surface wettability is another important factor that influences the interactions between the implant surface and the surrounding environment 13,14) . Various new surface treatments have emerged lately and have been reported [15][16][17][18] . As for SLA surface treatment, it has also been improved by modifying the treatment conditions 19) .…”

Section: Introductionmentioning

confidence: 99%

Surface Properties and Biocompatibility of Acid-etched Titanium

et al. 2008

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The purpose of this study was to evaluate the effects of acid-etched titanium on the biological responses of osteoblast-like MC3T3-E1 cells. Four types of treatments (polishing, sandblasting, concentrated H2SO4 etching, and concentrated H2SO4 etching with vacuum firing) were carried out on the surfaces of commercially pure titanium (cpTi) disks. MC3T3-E1 cells were then cultured on the treated cpTi surfaces. Through surface roughness measurement and SEM analysis, it was found that the acid-etched surfaces showed higher roughness values than the sandblasted ones. Scanning electron microscope analysis showed that the cells on the disks treated with acid-etching and acid-etching with vacuum firing spread as well as the sandblasted ones. There were no significant differences in cell proliferation and collagen production on cpTi among the four different surface treatments. Based on the results of this study, it was concluded that etching with concentrated sulfuric acid was a simple and effective way to roughen the surface of titanium without compromising its biocompatibility.

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Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies

Cited by 197 publications

References 38 publications

Force measurements with the atomic force microscope: Technique, interpretation and applications

Force measurements with the atomic force microscope: Technique, interpretation and applications

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

Surface Properties and Biocompatibility of Acid-etched Titanium

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