Surface engineering of low-fouling and hemocompatible polyethersulfone membranes via in-situ ring-opening reaction

Ji, Haifeng; Xu, Hao; Jin, Lunqiang; Song, Xin; He, Chao; Liu, Xiaoling; Xiong, Lian; Zhao, Weifeng; Zhao, Changsheng

doi:10.1016/j.memsci.2019.03.082

Cited by 38 publications

(29 citation statements)

References 42 publications

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“…Several previous studies on anti-fouling and biocompatibility have elucidated the platelet activation process or leukocyte factor activation using SEM photographs [22][23][24]. However, they have not shown protein adsorption layers actually fouling innermost surface pores of inner lumen of the capillary membrane in the order of nanometers.…”

Section: Observation Of Three-dimensional Tortuous Pores Of Inner Lumen Surface Of the Capillary Membranesmentioning

confidence: 99%

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

et al. 2020

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Hemoconcentration membranes used in cardiopulmonary bypass require a pore structure design with high pure water permeability, which does not allow excessive protein adsorption and useful protein loss. However, studies on hemoconcentration membranes have not been conducted yet. The purpose of this study was to analyze three-dimensional pore structures and protein fouling before and after blood contact with capillary membranes using the tortuous pore diffusion model and a scanning probe microscope system. We examined two commercially available capillary membranes of similar polymer composition that are successfully used in hemoconcentration clinically. Assuming the conditions of actual use in cardiopulmonary bypass, bovine blood was perfused inside the lumens of these membranes. Pure water permeability before and after bovine blood perfusion was measured using dead-end filtration. The scanning probe microscopy system was used for analysis. High-resolution three-dimensional pore structures on the inner surface of the membranes were observed before blood contact. On the other hand, many pore structures after blood contact could not be observed due to protein fouling. The pore diameters calculated by the tortuous pore diffusion model and scanning probe microscopy were mostly similar and could be validated reciprocally. Achievable pure water permeabilities showed no difference, despite protein fouling on the pore inlets (membrane surface). In addition, low values of albumin sieving coefficient are attributable to protein fouling that occurs on the membrane surface. Therefore, it is essential to design the membrane structure that provides the appropriate control of fouling. The characteristics of the hemoconcentration membranes examined in this study are suitable for clinical use.

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Section: Observation Of Three-dimensional Tortuous Pores Of Inner Lumen Surface Of the Capillary Membranesmentioning

confidence: 99%

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

et al. 2020

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“…Complement activation (C3a and C5a) for specimens was evaluated using commercial enzyme-linked immune sorbent assay (ELISA). 29 The whole blood was incubated with the tested samples at 37 °C for 1 h and centrifuged at 1000g for 15 min to obtain plasma. Then, the level of C3a and C5a was measured according to the respective instruction manuals (BD, Becton, Dickinson and Company).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…Complement activation (C3a and C5a) for specimens was evaluated using commercial enzyme-linked immune sorbent assay (ELISA) . The whole blood was incubated with the tested samples at 37 °C for 1 h and centrifuged at 1000 g for 15 min to obtain plasma.…”

Section: Experimental Sectionmentioning

confidence: 99%

Body Temperature-Triggered Shape-Memory Effect via Toughening Sustainable Poly(propylene carbonate) with Thermoplastic Polyurethane: toward Potential Application of Biomedical Stents

Zeng

Li-shen

et al. 2020

ACS Sustainable Chem. Eng.

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Shape-memory polymeric materials triggered by body temperature were fabricated via toughening sustainable poly(propylene carbonate) (PPC) with thermoplastic polyurethane (TPU). With an addition of TPU through melt blending, the ductility of PPC was dramatically enhanced, leading to the increase of shape recoverability but a deterioration of shape fixity. Remarkably, the blend containing 50 wt % TPU (PT50) presented the optimal shape-memory effect (SME) with balanced shape recovery and shape fixation performances because of the formation of the co-continuous structure promoting the synergy between PPC and TPU. Moreover, the PT50 sample exhibited significant improvement in not only the shape recovery ratio (∼95.0% recovery) but also the recovery speed and recovery stress, which enabled it to achieve an excellent SME when applied in practical use. After processed into a spiral-like stent, PT50 still showed a fast response to 37 °C, giving an efficient self-expansion within only 20 s. Besides, the blood and cell compatibility testing results revealed the good biocompatibility of PT50, further demonstrating the great potential of this material for development of biomedical stents.

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“…Polyhydroxyalkanoates (PHA) and poly(caprolactones) are two classes of biodegradable polymers that are well known (PCL). Poly(3-hydroxybutyric acid), one of the most widely used PHAs, has garnered a lot of attention as a drug carrier or scaffold biomaterial because, when compared to other biodegradable chemically produced polymers such as poly(lactide-co-glycolide) (PLGA), polylactate (PLA), polyglycolate (PGA), and polyethersulfone (PES) [183], it has a large number of advantages, such as remarkable biodegradability and biocompatibility, easier processibility, and controllable retarding properties. The modified membranes could maintain a stable flux under hemodialysis conditions, and a dynamic protein adsorption test was performed.…”

Section: Biocompatibility Propertiesmentioning

confidence: 99%

“…The modified membranes could maintain a stable flux under hemodialysis conditions, and a dynamic protein adsorption test was performed. Ji et al [183] studied poly(glycidyl methacrylate) (PGMA) incorporated into polyethersulfone (PES) membranes via a combination of an in situ crosslinking polymerization and the phase inversion method, and following this, poly(acrylic acid-co-2-acrylanmido-2-methylpropanesulfonic acid) (PAA-AMPS) was covalently coated onto the PES membrane surfaces via an in situ ring-opening reaction between the PAA and PGMA by simply immersing the membranes into the PAA-AMPS solution. The blood clots adhered on the surfaces of PES and PES/GMA membranes showed deformed erythrocytes entrapped in a fibrin mesh.…”

Section: Biocompatibility Propertiesmentioning

confidence: 99%

Surface Functionalities of Polymers for Biomaterial Applications

Drobotă¹,

Ursache²,

Aflori³

2022

Polymers

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Changes of a material biointerface allow for specialized cell signaling and diverse biological responses. Biomaterials incorporating immobilized bioactive ligands have been widely introduced and used for tissue engineering and regenerative medicine applications in order to develop biomaterials with improved functionality. Furthermore, a variety of physical and chemical techniques have been utilized to improve biomaterial functionality, particularly at the material interface. At the interface level, the interactions between materials and cells are described. The importance of surface features in cell function is then examined, with new strategies for surface modification being highlighted in detail.

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Surface engineering of low-fouling and hemocompatible polyethersulfone membranes via in-situ ring-opening reaction

Cited by 38 publications

References 42 publications

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

Validity of Three-Dimensional Tortuous Pore Structure and Fouling of Hemoconcentration Capillary Membrane Using the Tortuous Pore Diffusion Model and Scanning Probe Microscopy

Body Temperature-Triggered Shape-Memory Effect via Toughening Sustainable Poly(propylene carbonate) with Thermoplastic Polyurethane: toward Potential Application of Biomedical Stents

Surface Functionalities of Polymers for Biomaterial Applications

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