Our work clearly demonstrates the inhibitory effects of ropivacaine in breast cancer by disrupting mitochondrial function. Our findings provide a proper understanding of how local anesthetics reduce the risk of tumor recurrence, and thus, support the use of ropivacaine for surgery and to control pain in patients with breast cancer.
Shape-memory
polymeric materials triggered by body temperature
were fabricated via toughening sustainable poly(propylene carbonate)
(PPC) with thermoplastic polyurethane (TPU). With an addition of TPU
through melt blending, the ductility of PPC was dramatically enhanced,
leading to the increase of shape recoverability but a deterioration
of shape fixity. Remarkably, the blend containing 50 wt % TPU (PT50)
presented the optimal shape-memory effect (SME) with balanced shape
recovery and shape fixation performances because of the formation
of the co-continuous structure promoting the synergy between PPC and
TPU. Moreover, the PT50 sample exhibited significant improvement in
not only the shape recovery ratio (∼95.0% recovery) but also
the recovery speed and recovery stress, which enabled it to achieve
an excellent SME when applied in practical use. After processed into
a spiral-like stent, PT50 still showed a fast response to 37 °C,
giving an efficient self-expansion within only 20 s. Besides, the
blood and cell compatibility testing results revealed the good biocompatibility
of PT50, further demonstrating the great potential of this material
for development of biomedical stents.
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