Surface engineered nanostructured lipid carriers for efficient nose to brain delivery of ondansetron HCl using Delonix regia gum as a natural mucoadhesive polymer

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

“…Devkar et al [95] developed a biohybrid NLC based on glycerol monostearate and Capryol 90 as the lipid matrix, International Journal of Polymer Science stabilized with soy lecithin and poloxamer and superficially modified by the natural Delonix regia gum, combining mucoadhesive properties to the system. The hybrid system was intended for intranasal delivery of ondansetron and showed ca.…”

In vitro dissolution/release methods for mucosal delivery systems

“…The formulation loaded into upper donor compartment is separated from the receptor medium present in the lower compartment by a semipermeable membrane. Franz-diffusion cell was used to assess the drug release properties from numerous formulations aimed for nasal application, such as thermoresponsive soluble gels [55], ion activated in situ gels [56], microparticles [57], nanostructured lipid carriers [58], gel containing microspheres [59], lipidic emulsomes [60], in situ gelling microemulsions [61] and solid lipid nanoparticles [62]. This method is advantageous over other compendial and non-compendial membrane diffusion methods particularly in case of dry powders as it allows them to hydrate slowly, and gel eventually, in humid environment conditions designed to be similar to those encountered in the nasal cavity [63].…”

Ziprasidone Hydrochloride Loaded Nanostructured Lipid Carriers (Nlcs) for Intranasal Delivery: Optimization and in Vivo Studies

“…Further, 0.5 ml of supernatant was drawn from the obtained solutions and analyzed using electronic spectral studies at 315 nm (UV1800, Shimadzu, Japan). Additionally, for solid lipids, the minimum amount of molten lipids required to solubilize the desired drug was quantified via visual observation wherein the formation of a clear solution of melted lipids with ZRS was considered the endpoint [13].…”

“…Additionally, it was found that Gelucire 43/01 had formed a homogeneous mixture when combined with Capmul MCM without any phase separation for 24h, suggesting that the selected liquid lipid has completely entrapped in solid lipid which is the initial step in formulating the desired NLCs. On basing these solubility studies Capmul MCM and Gelucire 43/01 were selected as the lipid phase for further studies [13].…”