In vitro dissolution/release methods for mucosal delivery systems

Jug, Mario; Hafner, Anita; Lovrić, Jasmina; Kregar, Maja Lusina; Pepić, Ivan; Vanić, Željka; Cetina-Čižmek, Biserka; Filipović-Grčić, Jelena

doi:10.5599/admet.5.3.425

Cited by 10 publications

(6 citation statements)

References 54 publications

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“…A single film (15 × 15 × 0.6 mm) was placed on a metal mesh disc ( Figure 3 ) fixed with the help of a two-sided adhesive tape to avoid floating of the film during testing. The film was put on the upper side of the disc, together with the disc, immersed in the dissolution vessel [ 28 , 42 , 43 ]. Samples of 4 mL were taken from the medium at fixed time intervals (5, 10, 15, 30, 45, 60 min) and replaced with a fresh dissolution medium [ 44 ].…”

Section: Methodsmentioning

confidence: 99%

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

et al. 2021

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This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets—indicating that the therapeutic drug dose can be markedly reduced.

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Section: Methodsmentioning

confidence: 99%

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

et al. 2021

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“…For hydrophobic drugs, sometimes it is necessary to add surfactants that can provide the sink condition. In this study, Tween 80 was used as a surfactant, as previously used in other in vitro CUR drug release investigations [30,78]. Tween 80 can interfere with the structure and rheological properties of the peripheral area of the gel.…”

Section: Resultsmentioning

confidence: 99%

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

Ferreira¹,

Braga²,

Oliveira³

et al. 2019

Beilstein J. Nanotechnol.

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Mucoadhesive nanostructured systems comprising poloxamer 407 and Carbopol 974P® have already demonstrated good mucoadhesion, as well as improved mechanical and rheological properties. Curcumin displays excellent biological activity, mainly in oral squamous cancer; however, its physicochemical characteristics hinder its application. Therefore, the aim of this study was to develop nanostructured formulations containing curcumin for oral cancer therapy. The photophysical interactions between curcumin and the formulations were elucidated by incorporation kinetics and location studies. They revealed that the drug was quickly incorporated and located in the hydrophobic portion of nanometer-sized polymeric micelles. Moreover, the systems displayed plastic behavior with rheopexy characteristics at 37 °C, viscoelastic properties and a gelation temperature of 36 °C, which ensures increased retention after application in the oral cavity. The mucoadhesion results confirmed the previous findings with the nanostructured systems showing a residence time of 20 min in porcine oral mucosa under flow system conditions. Curcumin was released after 8 h and could permeate through the porcine oral mucosa. Cytotoxicity testing revealed that the formulations were selective to cancer cells over healthy cells. Therefore, these systems could improve the physicochemical characteristics of curcumin by providing improved release and permeation, while selectivity targeting cancer cells.

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“…2 × 3 cm) were carefully dropped into 10 mL dissolution medium under continuous orbital shaking (60 rpm) at 37˚C. Experimental conditions such as volume of the dissolution medium, shaking speed and temperature were chosen according to literatures [33,34,35,36,37].…”

Section: In Vitro Dissolution In Simulated Salivamentioning

confidence: 99%

Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva

Alhayali

Vuddanda

Velaga

2019

Journal of Drug Delivery Science and Technology

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In vitro dissolution/release methods for mucosal delivery systems

Abstract: In vitro dissolution/release tests are an indispensable tool in the drug product development, its quality

Cited by 10 publications

References 54 publications

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

Design of a nanostructured mucoadhesive system containing curcumin for buccal application: from physicochemical to biological aspects

Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva

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