Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva

Alhayali, Amani; Vuddanda, Parameswara Rao; Velaga, Sitaram P.

doi:10.1016/j.jddst.2019.06.019

Cited by 15 publications

(7 citation statements)

References 53 publications

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“…The strength determined by the TS is important for handling and packaging the OF. 60 Visser et al 61 defined as Critical Quality Attributes for orodispersible films TS >2 MPa and E > 10%, thus the OFs produced, regardless of the type of polymer, presented desirable mechanical properties for orodispersible films.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…On the other hand, CMC presented faster release since the maximum release of caffeine (81.1% ± 2.14) occurred after 4 min. Alhayali et al 60 observed, for HPMC-based films with silodosin, for the symptomatic treatment of benign prostatic hyperplasia in men, a release of 80% of the active principle after 10 min.…”

Section: In Vitro Release Profile and Release Kineticsmentioning

confidence: 99%

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A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

Lourenço

Garcia

Borges

et al. 2022

J of Applied Polymer Sci

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Oral films perform promising alternatives to traditional oral delivery systems to carry and deliver bioactive compounds directly into the oral cavity. The objective of this work was to produce and evaluate oral films based on carboxymethylcellulose (CMC), hydroxypropyl methylcellulose (HPMC) and pregelatinized starch incorporated with ethanolic extract from camu-camu industrial residue (EECCIR). Although all films can be ingested without causing irritation to the oral mucosa, due to near-neutral surface pH, the starchbased oral films with and without the addition of EECCIR showed reduced tensile strength (5.48 ± 0.97 MPa) indicating inferior mechanical properties to films based on CMC and HPMC. The CMC films, in addition to shorter disintegration time (50 ± 5 s), showed faster release, about 70% of phenolic compounds in 10 min and 100% in 30 min. As for the release profile, the application of the Korsmeyer and Peppas and Peppas and Sahlin models allowed to better understand the mechanisms involved in the release of phenolic compounds. Although all three oral film formulations can be used as carriers of active compounds from the ethanolic extract of the camu-camu residue, the oral films based on CMC incorporated with EECCIR showed greater potential.

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Section: Mechanical Propertiesmentioning

confidence: 99%

Section: In Vitro Release Profile and Release Kineticsmentioning

confidence: 99%

A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

Lourenço

Garcia

Borges

et al. 2022

J of Applied Polymer Sci

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“…The oral strip technology is formulated for a bedridden and geriatric patient who has difficulty in swallowing. [15] The solvent-casting method was used for preparing an OFDS by the direct casting of OLM NC into a polymeric solution. This oral strips help in improving the bioavailability of OLM.…”

Section: Original Articlementioning

confidence: 99%

Untitled

2022

IJGP

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Aim: Olmesartan medoxomil (OLM) is an antihypertensive drug available as an oral solid dosage form (tablet) with a restricted bioavailability of 28.6%. This might be attributed due to the low solubility and low permeability of the drug. The primary goal of this study was to enhance the solubility of OLM by formulating OLM nanocrystals (NC) and incorporating them into Oral Fast-Dissolving Strips (OFDSs) that will be made available for geriatric patients. Materials and Methods: Initially, nanosuspension (solvent-anti-solvent addition) was prepared using different concentrations of stabilizers and characterized for particle size (PS), polydispersity index (PDI), and zeta potential. Further, the nanosuspension was freeze-dried to obtain NC and it was characterized for crystallinity and surface morphology. In addition, the OLM NCs were incorporated into OFDS (solvent evaporation technique) and optimized by Multilevel Categoric design (2 4 × 2 2 ) using Design Expert ® software. The OFDS was evaluated for weight variation, thickness, tensile strength, drug content, disintegration time, and dissolution. Results and Discussion: F 30 shows PS, PDI, and zeta potential of 764.6 nm, 0.310, and −28.7 mV, respectively. The DSC thermograms showed that the reduction in crystallinity of OLM NC compared to pure OLM and the SEM images reveal rod-shaped crystals. The weight variation, thickness, surface pH, and drug content of OLM loaded OFDS obtained satisfactory results. The disintegration time, folding endurance, and tensile strength of the optimized formulation were found to be 20 ± 0.41 s, 125 ± 0.47 times, and 1328.8 ± 0.82 N/m, respectively. The drug release from the formulation was found to be 85.28% at the end of 5 min; the drug release kinetics indicated that it follows non-fickian diffusion and stability studies (25°C/60% RH) reveal that the formulation was stable. Conclusion:The results conclude that NCs approach is a promising techniques to improve solubility of poorly soluble drug.

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“…A modified petri dish method was adopted to evaluate the disintegration time of MD printed and cast ODFs (Alhayali et al, 2019). A watch glass with a 10 cm diameter containing 2 ml PBS pH 7.4 was equilibrated in a shaking incubator (KS 3000 I control, IKA, Germany) set at 60 rpm and 37 ± 0.5 °C.…”

Section: Disintegration Test Of Odfsmentioning

confidence: 99%

Drop-on-demand printing of personalised orodispersible films fabricated by precision micro-dispensing

Tam

Alexander

Belton

et al. 2021

International Journal of Pharmaceutics

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Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva

Abstract: Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva

Cited by 15 publications

References 53 publications

A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

A novel phenolic compounds delivery system: Oral films with extract from camu‐camu industrial residue

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Drop-on-demand printing of personalised orodispersible films fabricated by precision micro-dispensing

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