Abstract:Aim: Olmesartan medoxomil (OLM) is an antihypertensive drug available as an oral solid dosage form (tablet) with a restricted bioavailability of 28.6%. This might be attributed due to the low solubility and low permeability of the drug. The primary goal of this study was to enhance the solubility of OLM by formulating OLM nanocrystals (NC) and incorporating them into Oral Fast-Dissolving Strips (OFDSs) that will be made available for geriatric patients. Materials and Methods: Initially, nanosuspension (solvent… Show more
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