Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

Jovanović, Marija; Tomić, Nataša Z.; Cvijić, Sandra; Stojanović, Dušica; Ibrić, Svetlana; Uskoković, Petar S.

doi:10.3390/pharmaceutics13020273

Cited by 34 publications

(44 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Elastic property was assessed using the Young’s Modulus calculated from the slope of the linear elastic region of the curves. The equations to calculate these parameters are showed below [ 19 , 20 ]:

where: F = the force required to deform the membranes (N); A = the sectional area of nanofiber membrane (m 2 ); r = the radius of the tested membranes mounted on the clumping ring (cm); h = the thickness of the tested membranes (m); d = the displacement of membranes being punctured (cm). …”

Section: Methodsmentioning

confidence: 99%

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

et al. 2021

View full text Add to dashboard Cite

Electrospun nanofibers have been extensively studied for encapsulated drugs releasing from the inside of the fiber matrix, but have been barely looked at for their potential to control release as a semi-permeable membrane. This study investigated molecular transport behaviors across nanofiber membranes with different micro-structure sizes and compositions. Four types of membranes were made by 5% and 10% poly (ε-caprolactone) (PCL) solutions electro-spun with or without 50 nm calcium carbonate (CaCO3) nanoparticles. The membranes were tested for thickness, fiber diameter, pore size, porosity, tensile strength and elongation, contact angle of water and their impacts on molecular transport behaviors. The presence of the CaCO3 nanoparticles made the 5% membranes stronger and stiffer but the 10% membranes weaker and less stiff due to the different (covering or embedded) locations of the nanoparticles with the corresponding fibers. Solute transport studies using caffeine as the model drug found the 5% membranes further retarded release from the 10% membranes, regardless of only half the amount of material being used for synthesis. The addition of CaCO3 nanoparticles aided the water permeation process and accelerated initial transports. The difference in release profiles between 5% and 10% membranes suggests different release mechanisms, with membrane-permeability dominated release for 5% PCL membranes and solute-concentration-gradient dominated release for 10% PCL membranes.

show abstract

Section: Methodsmentioning

confidence: 99%

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In recent years, various mucoadhesive polymers have been investigated for prolonging the retention time of dosage forms or actives at targeted sites of oral mucosa. The most frequently used polymers in buccal dosage forms include poly(acrylic acid) and its copolymers such as acrylic acid polyethylene glycol (PEG) monomethyl ether copolymer, polyvinyl alcohol (PVA), chitosan, sodium alginate, gelatin, carrageenan, hyaluronic acid [ 13 , 41 , 42 , 43 , 44 ], cellulose derivatives such as sodium carboxymethyl cellulose (NaCMC), hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC), eudragit RS 100 [ 45 ]. Positively charged, biocompatible and biodegradable natural polymer, chitosan has been widely exploited as mucoadhesive polymer because of its electrostatic interaction with the negatively charged O-linked oligosaccharide chain of mucin [ 46 ].…”

Section: Design and Formulation Of Buccal Drug-delivery Systemsmentioning

confidence: 99%

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

et al. 2021

View full text Add to dashboard Cite

Buccal mucosal membrane offers an attractive drug-delivery route to enhance both systemic and local therapy. This review discusses the benefits and drawbacks of buccal drug delivery, anatomical and physiological aspects of oral mucosa, and various in vitro techniques frequently used for examining buccal drug-delivery systems. The role of mucoadhesive polymers, penetration enhancers, and enzyme inhibitors to circumvent the formulation challenges particularly due to salivary renovation cycle, masticatory effect, and limited absorption area are summarized. Biocompatible mucoadhesive films and patches are favored dosage forms for buccal administration because of flexibility, comfort, lightness, acceptability, capacity to withstand mechanical stress, and customized size. Preparation methods, scale-up process and manufacturing of buccal films are briefed. Ongoing and completed clinical trials of buccal film formulations designed for systemic delivery are tabulated. Polymeric or lipid nanocarriers incorporated in buccal film to resolve potential formulation and drug-delivery issues are reviewed. Vaccine-enabled buccal films have the potential ability to produce both antibodies mediated and cell mediated immunity. Advent of novel 3D printing technologies with built-in flexibility would allow multiple drug combinations as well as compartmentalization to separate incompatible drugs. Exploring new functional excipients with potential capacity for permeation enhancement of particularly large-molecular-weight hydrophilic drugs and unstable proteins, oligonucleotides are the need of the hour for rapid advancement in the exciting field of buccal drug delivery.

show abstract

“…Five replicates were conducted for each film. The mechanical strength of the film was characterized by tensile strength, elongation at break, and Young's modulus [16][17][18].…”

Section: Mechanical Strength Testmentioning

confidence: 99%

Extraction of Nicotine from Tobacco Leaves and Development of Fast Dissolving Nicotine Extract Film

et al. 2021

View full text Add to dashboard Cite

Nicotine (NCT), administered in the form of a fast dissolving oral delivery system, can be a potential alternative to nicotine replacement therapy. NCT was extracted by maceration and acid-base extraction methods from Burley tobacco leaves with different stalk positions and extraction yield and NCT content were further determined. The extract with the highest nicotine content was selected for incorporation into a fast dissolving film formulation. The optimized film was evaluated for its physical and mechanical properties, in vitro disintegration, and drug release profile. The results demonstrated that the extract from the upper part of tobacco leaves using the acid-base extraction method had the highest amount of NCT. NCT fast dissolving film consisting of this extract as the active ingredient and HPMC E15 as a film polymer resulted in a homogeneous translucent film with a light brown color. The addition of NCT significantly affected the film properties in terms of weight, disintegration time, tensile strength, percentage elongation at break, and Young’s modulus values. The drug release of NCT fast dissolving film showed a rapid initial release of 80% within three minutes, and its kinetics followed the Higuchi matrix model. The results suggest that these NCT films can be employed in the development of NCT fast dissolving films for clinical use.

show abstract

Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties

Cited by 34 publications

References 86 publications

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

Electrospun Membranes as a Porous Barrier for Molecular Transport: Membrane Characterization and Release Assessment

An Updated Overview of the Emerging Role of Patch and Film-Based Buccal Delivery Systems

Extraction of Nicotine from Tobacco Leaves and Development of Fast Dissolving Nicotine Extract Film

Contact Info

Product

Resources

About