Surface antimicrobial activity and biocompatibility of incorporated polyethylenimine nanoparticles

Beyth, Nurit; Houri‐Haddad, Yael; Baraness-Hadar, Liat; Yudovin-Farber, Ira; Domb, Abraham J.; Weiss, Ervin I.

doi:10.1016/j.biomaterials.2008.07.003

Cited by 197 publications

(160 citation statements)

References 35 publications

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“…More recently, drug delivery (14) and nanotechnology strategies (15) involving functionalization of biomaterials by surface coating (16,17), impregnation, or embedding (18,19) have emerged as a more effective approach for localized sustained antimicrobial control of medical biofilms. Lipidand polymer-based drug carriers are the most exploited in this respect.…”

Section: Introductionmentioning

confidence: 99%

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

et al. 2014

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Abstract. A new vancomycin (VCM)-eluting mixed bilayer niosome formulation was evaluated for the control of staphylococcal colonization and biofilm formation on abiotic surfaces, a niosome application not explored to date. Cosurfactant niosomes were prepared using a Span 60/Tween 40/cholesterol blend (1: 1: 2). Tween 40, a polyethoxylated amphiphile, was included to enhance VCM entrapment and confer niosomal surface properties precluding bacterial adhesion. VCM-eluting niosomes showed good quality attributes including relatively high entrapment efficiency (∼50%), association of Tween 40 with vesicles in a constant proportion (∼87%), biphasic release profile suitable for inhibiting early bacterial colonization, and long-term stability at 4°C for a 12-month study period. Niosomes significantly enhanced VCM activity against planktonic bacteria of nine staphylococcal strains. Using microtiter plates as abiotic surface, VCM-eluting niosomes proved superior to VCM in inhibiting biofilm formation, eradicating surface-borne biofilms, inhibiting biofilm growth, and interfering with biofilm induction by VCM subminimal inhibitory concentrations. Data suggest dual functionality of cosurfactant VCM-eluting niosomes as passive colonization inhibiting barrier and active antimicrobial-controlled delivery system, two functions recognized in infection control of abiotic surfaces and medical devices.

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Section: Introductionmentioning

confidence: 99%

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

et al. 2014

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“…PEI prepared in nanoparticles was incorporated in dental provisional cements and found to had antibacterial effect against Streptococcus mutans [14]. Insoluble crosslinked quaternary ammonium polyethylenimine (PEI) nanoparticles incorporated at 1 or 2% w/w in a resin composite also have an antimicrobial effect against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli [15].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Polyethylenimine/Carrageenan Multilayer against Pathogenic Bacteria

Briones¹,

Sato²,

Bigol³

2014

ACES

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The multilayer of polyethylenimine (PEI) and carrageenan (κ, ι, λ) formed by layer-by-layer assembly was investigated for its antibacterial activity against Enterobacter cloaceae, Staphylococcus aureus and Enterococcus faecalis 29505 for potential use as coating on biomaterial surface. All the multilayers exhibited growth inhibition. PEI/Iota carrageenan multilayer was effective in inhibiting the growth of the E. cloaceae, S. aureus and E. faecalis while PEI/Lambda carrageenan was effective in inhibiting the growth of E. cloaceae. Results of the paper strip test for combined action of carrageenan and PEI showed synergism with regards to bacterial growth inhibition. The multilayers had also contact-killing effect with the test organisms. The multilayer was also characterized by atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS) and biomolecular interaction analysis.

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“…Therefore, the use of these assays in determining dental and medical materials with antibacterial properties is questionable (Beyth et al, 2008). Dental composites with sudden content-releasing characteristics are undesirable in clinics due to their short-term effectiveness that do not fulfill the medical requirements.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and cytotoxic properties of boron-containing dental composite

Demirci¹,

Kaya²,

Doğan³

et al. 2015

Turk J Biol

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Secondary dental caries are one of the major reasons for restoration replacements. Incorporating antimicrobial properties into dental materials would limit the initiation and progression of dental caries. In the current study, dental composites having 1%, 5%, and 10% (w/w) sodium pentaborate pentahydrate were prepared and analyzed for their mechanical properties, degree of monomer conversion (DC) rate, antibacterial effects against Streptococcus mutans, and biocompatibility with human dental pulp stem cells (hDPSCs). Incorporation of boron into the composites significantly decreased flexural strength and DC in a dose-dependent manner, but the value for 1% boron-containing composite still remained within acceptable levels. Compressive strength and diametral tensile strength were not found to be different from those of controls. Although no inhibition zone was detected in an agar-well diffusion assay for any materials tested, significant bacterial growth inhibition was obtained in a direct contact test for boron-containing composites. Immunocytochemical and lineage-specific gene expression analysis revealed that composites with boron content increased the osteogenic and odontogenic capacity of hDPSCs. Boron-containing dental composites showed promising results for future clinical applications, displaying nontoxic, osteogenic, and odontogenic-inducing characteristics with remarkable antibacterial activity against S. mutans, and are hence potentially able to prevent secondary caries.

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Surface antimicrobial activity and biocompatibility of incorporated polyethylenimine nanoparticles

Cited by 197 publications

References 35 publications

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

Vancomycin-Eluting Niosomes: A New Approach to the Inhibition of Staphylococcal Biofilm on Abiotic Surfaces

Antibacterial Activity of Polyethylenimine/Carrageenan Multilayer against Pathogenic Bacteria

Antibacterial and cytotoxic properties of boron-containing dental composite

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