Surface analysis and bioreactions of F and Si containing a-C:H

Hauert, Roland; Müller, Ulrich; Francz, G.; Birchler, F; Schroeder, A.; Mayer, J.; Wintermantel, E.

doi:10.1016/s0040-6090(97)00422-7

Cited by 46 publications

(21 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The timescale to clinical approval for a given application is necessarily long and a number of significant challenges are presented along the way. In-vitro analysis presents a very wide range of possibilities and the DLC response to proteins [3,4], platelets [45,6,7,43] and cell types, including human [8,9] and other fibroblasts [10], osteoblasts [9,11], red [4] and white [9,12] blood cells, endothelial cells [44] and macrophages [12][13][14], among others, has received attention. Early cell adhesion and shape, cell number and activation are the main analysis parameters determined from a range of visual and biological tests.…”

Section: Introductionmentioning

confidence: 99%

Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires

Maguire

McLaughlin

Okpalugo

et al. 2005

Diamond and Related Materials

181

104

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires

Maguire

McLaughlin

Okpalugo

et al. 2005

Diamond and Related Materials

181

104

View full text Add to dashboard Cite

“…The composition of the Si based interlayer is approximately 58± 3% Si, 35± 3% O, 7 ± 2% N assuming that the carbon signal measured in the range of in the interlayer arose from the DLC-coating due to a limited depth resolution. This assumption is supported by the position of the C1s signals which are throughout the depth profile at 284.8 eV, the position of carbon in the form of DLC and not at the position of SiC at 283.3-283.6 eV [8].…”

Section: Xps Depth Profilingmentioning

confidence: 91%

Analysis of the in-vivo failure of the adhesive interlayer for a DLC coated articulating metatarsophalangeal joint

Hauert

Thorwarth

Müller

et al. 2012

Diamond and Related Materials

View full text Add to dashboard Cite

“…They found homogeneous and optimal tissue integration (fine cytoplasmic extensions) for pure and up to 22 at% Si doped coatings. Studies on RF PE-CVD deposited hydrogenated carbonitride coatings (a-C:H:N) with osteoblast and fibroblast cells revealed generally good biocompatibility of the coatings [157,158]. Schroeder et al [159] performed bone marrow cell culture tests on Ti-incorporated hydrogenated carbon films (prepared by a combination of RF PE-CVD and magnetron sputtering) and found increased bone cell proliferation and minimum activity of osteoclasts.…”

Section: Carbon-based Coating Materialsmentioning

confidence: 99%

Inorganic PVD and CVD Coatings in Medicine — A Review of Protein and Cell Adhesion on Coated Surfaces

Lackner

Waldhauser

2010

Journal of Adhesion Science and Technology

View full text Add to dashboard Cite

The functionalization of biomaterials for implants becomes increasingly important for designing bioinert and bioactive surfaces to reduce the impact of implantation to human body (inflammation, encapsulation) and extend the lifetime of implants. Even pharmacological effects can be triggered by nanomaterials like thin films and nanoparticles in medical treatment. However, the systematic knowledge of the interactions between cells and artificial, inorganic materials is poor yet. Finding the decisive influences for high hemocompatibility or osseointegration is very difficult. Surface chemistry including wetting behaviour, surface charge, homogeneity and functional groups as well as surface topography are some of the fundamental surface parameters defining the cell-surface interaction. Focusing on physical and chemical vapour deposited thin films and coatings, this review will provide for a better understanding of biocompatible coating materials like titanium-and carbon-based compounds and calcium phosphates. of the main goals of biomaterials research [3,4]. However, the precise mechanisms involved in this cell-surface and protein-surface interactions are still unknown.Generally, surfaces of synthetic biomaterials (e.g., polymers, metals and ceramics) are not bioactive themselves. Rather, surface bioactivity is provided by the proteins that adsorb to the biomaterial surface following exposure of the surface to biological fluids. The first molecules are water molecules reaching the surface in a biological milieu containing cells. When cells arrive at the surface, they 'see' a protein-covered surface whose bioactive protein layer has properties that were initially determined by the pre-formed water shells. To control cellular response, it is important to first understand how surface chemistry, surface topography and mechanical forces influence the formation of the adsorbed protein layer and the bioactive sites presented by this layer. Besides water, proteins and cells, biological model systems for biointerfaces (or surfaces) must contain amino acids, nucleic acids and lipids, peptides and DNA (segments), and tissue to describe the sequences occurring in the human body [5]. The recognition of these molecular-scale features is programmed into the molecules through the combination of their 3-D topographic architecture, the superimposed chemical architecture, and the dynamic properties [5]. Although the fundamental interactions occur on the molecular scale, there is an interesting and unique synergistic connection between the nanometer and the micrometer length scales [6-8], when cells are present.Recent advances in topographical surface modification techniques such as electron beam lithography [9], photolithography [10], colloidal lithography [11,12], laser ablation [13] and polymer demixing [14] have allowed the fabrication of surfaces with nano-sized features. In addition, the modification of the surface chemistry by coating with biomaterials or biomolecules of 'higher biocompatibility' helps to separate between bulk pr...

show abstract

Surface analysis and bioreactions of F and Si containing a-C:H

Cited by 46 publications

References 13 publications

Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires

Mechanical stability, corrosion performance and bioresponse of amorphous diamond-like carbon for medical stents and guidewires

Analysis of the in-vivo failure of the adhesive interlayer for a DLC coated articulating metatarsophalangeal joint

Inorganic PVD and CVD Coatings in Medicine — A Review of Protein and Cell Adhesion on Coated Surfaces

Contact Info

Product

Resources

About