Supramolecular three-armed star polymers via cyclodextrin host–guest self-assembly

Schmidt, Bernhard V. K. J.; Rudolph, Tobias; Hetzer, Martin; Ritter, Helmut; Schacher, Felix H.; Barner‐Kowollik, Christopher

doi:10.1039/c2py20293j

Cited by 74 publications

(71 citation statements)

References 58 publications

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“…Besides micelles and vesicles, star polymer architectures have also been assembled via CD‐based host–guest interactions . This concept was recently demonstrated by Ritter et al, who synthesized star polymers utilizing CD‐based inclusion complexation.…”

Section: Cyclodextrin‐based Supramolecular Polymersmentioning

confidence: 99%

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Tan

Ladewig

et al. 2014

Macromol. Rapid Commun.

145

115

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encompasses an array of noncovalent interactions that can yield highly complex and ordered structures. As a result of their wide availability and negligible toxicity cyclodextrins (CDs) are one of the most widely used hosts in the fi eld of inclusion chemistry. Usually composed of six to eight D -glucose units, CDs are capable of forming inclusion complexes with various guest moieties and polymeric chains. This capability is attributed to their ether-like oxygen and their hydrocarbon frame creating a hydrophobic cavity wherein appropriately sized molecules and macromolecules can be immobilized via tight, yet reversible associations. Using CD-based inclusion chemistry as a platform, a diverse range of polymeric networks with applications in the life sciences, biotechnology, and materials science can be achieved. This review highlights the versatility of CDbased inclusion chemistry, and how specifi city and control can be imparted when designing higher-order structures, such as those found in biological systems. A particularly interesting group of polymeric structures that is achievable via CD-based inclusion chemistry is that of CD-based The application of cyclodextrin (CD)-based host-guest interactions towards the fabrication of functional supramolecular assemblies and hydrogels is of particular interest in the fi eld of biomedicine. However, as of late they have found new applications as advanced functional materials (e.g., actuators and self-healing materials), which have renewed interest across a wide range of fi elds. Advanced supramolecular materials synthesized using this noncovalent interaction, exhibit specifi city and reversibility, which can be used to impart reversible cross-linking, specifi c binding sites, and functionality. In this review, various functional CD-based supramolecular assemblies and hydrogels will be outlined with the focus on recent advances. In addition, an outlook will be provided on the direction of this rapidly developing fi eld.

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Section: Cyclodextrin‐based Supramolecular Polymersmentioning

confidence: 99%

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Tan

Ladewig

et al. 2014

Macromol. Rapid Commun.

145

115

View full text Add to dashboard Cite

show abstract

“…Among various macromolecular architectures such as linear, graft, branched, dendritic, brush, and cyclic polymers, star polymers have remained one of the most studied categories, and recent years have witnessed increasingly intensive research in their synthesis, characterization, property investigation, and application. Interests in harnessing non‐covalent interactions to produce supramolecular star polymers are rapidly evolving . Novel degradable polyester‐ and polypeptide‐based star polymers have been pushed to a new height using metal‐free polymerizations .…”

Section: Introductionmentioning

confidence: 99%

Emerging Synthetic Strategies for Core Cross‐Linked Star (CCS) Polymers and Applications as Interfacial Stabilizers: Bridging Linear Polymers and Nanoparticles

Chen

Cao

et al. 2013

Macromol. Rapid Commun.

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Core cross-linked star (CCS) polymers become increasingly important in polymer science and are evaluated in many value-added applications. However, limitations exist to varied degrees for different synthetic methods. It is clear that improvement in synthetic efficiency is fundamental in driving this field moving even further. Here, the most recent advances are highlighted in synthetic strategies, including cross-linking with cross-linkers of low solubility, polymerization-induced self-assembly in aqueous-based heterogeneous media, and cross-linking via dynamic covalent bonds. The understanding of CCS polymers is also further refined to advocate their role as an intermediate between linear polymers and polymeric nanoparticles, and their use as interfacial stabilizers is rationalized within this context.

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“…A preceding survey of the literature shows that the equilibrium binding constant for the simplest inclusion complexes based on one of the three native CDs (α-, βand γ-CDs) and various guest molecules at equivalent molar ranges from 1 to 10 6 M −1 with a population mean of 10 2 to 10 3 M −1 . Barner-Kowollik's group, for example, constructed a series of novel polymer architectures including three-arm, 36 miktoarm, 37 and X-and H-shaped 38 star block copolymers via the combination of state-of-the-art polymer chemistry techniques (RAFT and copper(I)-catalyzed azidealkyne cycloaddition) and CD-AD driven supermolecular selfassembly. β-CD and adamantane (AD), as the most extensively investigated pair with a strong binding constant of around 1 × 10 5 M −1 in water, 17 has been widely used in polymer fabrication.…”

Section: Cd-centered/bridged Polymersmentioning

confidence: 99%

Cyclodextrin-functionalized polymers as drug carriers for cancer therapy

Wei

2015

Biomater. Sci.

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Cyclodextrins (CDs) represent the most extensively investigated cyclic molecules due to their wide availability, facile functionalization, unique amphiphilicity and inclusion capacity. The marriage of CD chemistry with polymer science has generated novel biomaterials by integrating supermolecular host-guest chemistry and state-of-the-art polymer chemistry techniques. The current mini-review focuses on the recent progress in CD-functionalized polymers as drug carriers for cancer therapy. CD-functionalized polymers with different structures are summarized. Their application as drug carriers for cancer therapy is then highlighted. In the end, the future directions of this rapidly developing research field are discussed.

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Supramolecular three-armed star polymers via cyclodextrin host–guest self-assembly

Cited by 74 publications

References 58 publications

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Emerging Synthetic Strategies for Core Cross‐Linked Star (CCS) Polymers and Applications as Interfacial Stabilizers: Bridging Linear Polymers and Nanoparticles

Cyclodextrin-functionalized polymers as drug carriers for cancer therapy

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