Supramolecular Systems Based on Macrocyclic Compounds with Proteins: Application Prospects

Лебедева, Н.С.; Койфман, О. И.

doi:10.1134/s1068162022010071

Cited by 5 publications

(1 citation statement)

References 226 publications

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“…On the other hand, Gram-negative bacteria have a polysaccharide membrane above the peptidoglycan layer [47,51]. Upon semiconductor activation, the ROS oxidize the peptidoglycan layer and the polysaccharide layer, facilitating the reduction in cell viability in the system [52,53]. Cell membrane destruction can also occur through the interaction between microbes and particles from the deposition of bacteria on the semiconductor agglomerate [30].…”

Section: Gkt + Hν → Gkt + E + Hmentioning

confidence: 99%

TiO2/Karaya Composite for Photoinactivation of Bacteria

et al. 2022

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A TiO2/Karaya composite was synthesized by the sol-gel method for the photoinactivation of pathogens. This is the first time that we have reported this composite for an antimicrobial approach. The structure, morphology, and optical properties were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-rays (EDS), Fourier transform infrared spectroscopy (FTIR), and diffuse reflectance, and the surface area was characterized by the BET method. The XRD and EDS results showed that the TiO2/Karaya composite was successfully stabilized by the crystal structure and pore diameter distribution, indicating a composite of mesoporous nature. Furthermore, antibacterial experiments showed that the TiO2/Karaya composite under light was able to photo-inactivate bacteria. Therefore, the composite is a promising candidate for inhibiting the growth of bacteria.

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Section: Gkt + Hν → Gkt + E + Hmentioning

confidence: 99%

TiO2/Karaya Composite for Photoinactivation of Bacteria

et al. 2022

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Synthesis of water-soluble porphyrin with tyrosine fragments and study of its interaction with S-protein of SARS-CoV-2

et al. 2022

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The multistage purposeful synthesis of 5,15-bis(4′- l - N -tyrosinylamidophenyl)-10,20-bis( N -methylpyridin-3′-yl)porphine diiodide was carried out, and the optimum synthesis conditions were determined. 5,15-Bis(4′-nitrophenyl)-10,20-bis(pyridin-3′-yl)porphine served as the starting porphyrin. The structure, individual character, and purity of the target compound were proved by electron spectroscopy, 1 H NMR spectroscopy, mass spectrometry (MALDI TOF), and TLC. Specific features of the interaction of the synthesized porphyrin with S-protein of SARS-CoV-2 were studied using spectral and thermochemical methods, including conditions of photoirradiation. The photoirradiation of the synthesized porphyrin in a complex with the SARS-CoV-2 S-protein can result in the partial oxidation of amino acid residues of the protein and distort its primary and secondary structures. The photoirradiation of the S-protein complex with the porphyrin decreases its thermal resistance to melting by 15 °C compared to the free S-protein and causes porphyrin release.

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